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Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol.
Eur J Nutr 2007; 46(2):111-7EJ

Abstract

BACKGROUND

Oil-based matrices enriched with plant stanol esters lower serum LDL cholesterol. The effects of low-fat milk products have been less thoroughly examined.

AIM OF THE STUDY

To evaluate the effect of three less explored low-fat milk products enriched with plant stanol esters on serum lipid concentrations in subjects with mild or moderate hypercholesterolemia.

METHODS

A meta-analysis of four unpublished sub-studies (yoghurt, yoghurt single-shot drink: Studies I and II, or milk). All the substudies were randomized, placebo-controlled, double-blind and had a parallel-group design. They were carried out in order to evaluate the effect of low-fat milk products enriched with plant stanol esters on serum lipid concentration. Each stanol-ester-enriched milk product provided 2 g of stanols per day, and in each study the intervention period was 5 weeks. A total of 199 hypercholesterolemic subjects completed the studies.

RESULTS

The pooled treatment difference in total cholesterol was -3.8% (95% CI -6.0 to -1.7, p < 0.001) when stanol was compared to placebo. In LDL cholesterol, the pooled treatment difference was -4.9% (95% CI -7.8 to -1.8, p = 0.002). There were no significant differences between the groups in pooled HDL cholesterol or triacylglycerol concentrations. The results tended to be more pronounced when we were certain that the yoghurt single-shot drink was ingested with lunch, and when the baseline LDL-cholesterol concentration was > or = 3.5 mmol/l.

CONCLUSIONS

These results imply that low-fat milk products enriched with plant stanol esters lower both total cholesterol and LDL cholesterol statistically significantly in subjects with mild or moderate hypercholesterolemia. The changes tended to relate to the baseline LDL-cholesterol concentration.

Authors+Show Affiliations

Valio Ltd, Helsinki, Finland. leena.seppo@valio.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17225918

Citation

Seppo, Leena, et al. "Plant Stanol Esters in Low-fat Milk Products Lower Serum Total and LDL Cholesterol." European Journal of Nutrition, vol. 46, no. 2, 2007, pp. 111-7.
Seppo L, Jauhiainen T, Nevala R, et al. Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol. Eur J Nutr. 2007;46(2):111-7.
Seppo, L., Jauhiainen, T., Nevala, R., Poussa, T., & Korpela, R. (2007). Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol. European Journal of Nutrition, 46(2), pp. 111-7.
Seppo L, et al. Plant Stanol Esters in Low-fat Milk Products Lower Serum Total and LDL Cholesterol. Eur J Nutr. 2007;46(2):111-7. PubMed PMID: 17225918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol. AU - Seppo,Leena, AU - Jauhiainen,Tiina, AU - Nevala,Riikka, AU - Poussa,Tuija, AU - Korpela,Riitta, PY - 2006/05/11/received PY - 2006/12/06/accepted PY - 2007/1/18/pubmed PY - 2007/10/24/medline PY - 2007/1/18/entrez SP - 111 EP - 7 JF - European journal of nutrition JO - Eur J Nutr VL - 46 IS - 2 N2 - BACKGROUND: Oil-based matrices enriched with plant stanol esters lower serum LDL cholesterol. The effects of low-fat milk products have been less thoroughly examined. AIM OF THE STUDY: To evaluate the effect of three less explored low-fat milk products enriched with plant stanol esters on serum lipid concentrations in subjects with mild or moderate hypercholesterolemia. METHODS: A meta-analysis of four unpublished sub-studies (yoghurt, yoghurt single-shot drink: Studies I and II, or milk). All the substudies were randomized, placebo-controlled, double-blind and had a parallel-group design. They were carried out in order to evaluate the effect of low-fat milk products enriched with plant stanol esters on serum lipid concentration. Each stanol-ester-enriched milk product provided 2 g of stanols per day, and in each study the intervention period was 5 weeks. A total of 199 hypercholesterolemic subjects completed the studies. RESULTS: The pooled treatment difference in total cholesterol was -3.8% (95% CI -6.0 to -1.7, p < 0.001) when stanol was compared to placebo. In LDL cholesterol, the pooled treatment difference was -4.9% (95% CI -7.8 to -1.8, p = 0.002). There were no significant differences between the groups in pooled HDL cholesterol or triacylglycerol concentrations. The results tended to be more pronounced when we were certain that the yoghurt single-shot drink was ingested with lunch, and when the baseline LDL-cholesterol concentration was > or = 3.5 mmol/l. CONCLUSIONS: These results imply that low-fat milk products enriched with plant stanol esters lower both total cholesterol and LDL cholesterol statistically significantly in subjects with mild or moderate hypercholesterolemia. The changes tended to relate to the baseline LDL-cholesterol concentration. SN - 1436-6207 UR - https://www.unboundmedicine.com/medline/citation/17225918/Plant_stanol_esters_in_low_fat_milk_products_lower_serum_total_and_LDL_cholesterol_ L2 - https://dx.doi.org/10.1007/s00394-006-0639-2 DB - PRIME DP - Unbound Medicine ER -