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Sensitivity disturbances in patients with irritable bowel syndrome and fibromyalgia.
Am J Gastroenterol. 2006 Dec; 101(12):2782-9.AJ

Abstract

BACKGROUND

Although visceral hypersensitivity is a common feature among patients with irritable bowel syndrome (IBS), studies on somatic sensitivity have given controversial results.

AIM

To assess visceral sensitivity in response to isotonic rectal distensions and somatic sensitivity at different layers of the body wall (skin, subcutis, and muscle) in patients with IBS and fibromyalgia (FM), within and outside the area of abdominal pain referral.

MATERIALS AND METHODS

We studied 10 patients with IBS, 5 patients with FM, 9 patients with IBS+FM, and 9 healthy controls. Rectal distensions were performed by increasing tension at 4 g steps up to 64 g or discomfort. Pain thresholds to electrical stimulation were measured within and outside the areas of abdominal pain referral.

RESULTS

Patients with IBS and IBS+FM demonstrated rectal hypersensitivity in comparison to controls. The threshold of discomfort was 44 +/- 5 g in IBS and 36 +/- 5 in IBS+FM patients, while patients with FM and healthy controls tolerated all distensions without discomfort. In the areas of pain referral, pain thresholds of all three tissues of the body wall were lower than normal in all patients groups (p < 0.001). In control areas, the pain thresholds were normal in skin, and lower than normal in subcutis and muscle in IBS (p < 0.001). FM and IBS+FM demonstrated somatic hypersensitivity at all sites (p < 0.001 vs healthy).

CONCLUSION

Our observations seem to indicate that, although sharing a common hypersensitivity background, multiple mechanisms may modulate perceptual somatic and visceral responses in patients with IBS and FM.

Authors+Show Affiliations

Department of Medicine and Aging Sciences, Section of Internal Medicine and Gastroenterology, Centre for the Study of Aging, Gabriele D'Annunzio University and Foundation, Chieti, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17227524

Citation

Caldarella, Maria P., et al. "Sensitivity Disturbances in Patients With Irritable Bowel Syndrome and Fibromyalgia." The American Journal of Gastroenterology, vol. 101, no. 12, 2006, pp. 2782-9.
Caldarella MP, Giamberardino MA, Sacco F, et al. Sensitivity disturbances in patients with irritable bowel syndrome and fibromyalgia. Am J Gastroenterol. 2006;101(12):2782-9.
Caldarella, M. P., Giamberardino, M. A., Sacco, F., Affaitati, G., Milano, A., Lerza, R., Balatsinou, C., Laterza, F., Pierdomenico, S. D., Cuccurullo, F., & Neri, M. (2006). Sensitivity disturbances in patients with irritable bowel syndrome and fibromyalgia. The American Journal of Gastroenterology, 101(12), 2782-9.
Caldarella MP, et al. Sensitivity Disturbances in Patients With Irritable Bowel Syndrome and Fibromyalgia. Am J Gastroenterol. 2006;101(12):2782-9. PubMed PMID: 17227524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitivity disturbances in patients with irritable bowel syndrome and fibromyalgia. AU - Caldarella,Maria P, AU - Giamberardino,Maria A, AU - Sacco,Flora, AU - Affaitati,Giannapia, AU - Milano,Angelo, AU - Lerza,Rosanna, AU - Balatsinou,Crysanthi, AU - Laterza,Francesco, AU - Pierdomenico,Sante D, AU - Cuccurullo,Franco, AU - Neri,Matteo, PY - 2007/1/18/pubmed PY - 2007/2/9/medline PY - 2007/1/18/entrez SP - 2782 EP - 9 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 101 IS - 12 N2 - BACKGROUND: Although visceral hypersensitivity is a common feature among patients with irritable bowel syndrome (IBS), studies on somatic sensitivity have given controversial results. AIM: To assess visceral sensitivity in response to isotonic rectal distensions and somatic sensitivity at different layers of the body wall (skin, subcutis, and muscle) in patients with IBS and fibromyalgia (FM), within and outside the area of abdominal pain referral. MATERIALS AND METHODS: We studied 10 patients with IBS, 5 patients with FM, 9 patients with IBS+FM, and 9 healthy controls. Rectal distensions were performed by increasing tension at 4 g steps up to 64 g or discomfort. Pain thresholds to electrical stimulation were measured within and outside the areas of abdominal pain referral. RESULTS: Patients with IBS and IBS+FM demonstrated rectal hypersensitivity in comparison to controls. The threshold of discomfort was 44 +/- 5 g in IBS and 36 +/- 5 in IBS+FM patients, while patients with FM and healthy controls tolerated all distensions without discomfort. In the areas of pain referral, pain thresholds of all three tissues of the body wall were lower than normal in all patients groups (p < 0.001). In control areas, the pain thresholds were normal in skin, and lower than normal in subcutis and muscle in IBS (p < 0.001). FM and IBS+FM demonstrated somatic hypersensitivity at all sites (p < 0.001 vs healthy). CONCLUSION: Our observations seem to indicate that, although sharing a common hypersensitivity background, multiple mechanisms may modulate perceptual somatic and visceral responses in patients with IBS and FM. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/17227524/Sensitivity_disturbances_in_patients_with_irritable_bowel_syndrome_and_fibromyalgia_ L2 - https://Insights.ovid.com/pubmed?pmid=17227524 DB - PRIME DP - Unbound Medicine ER -