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Does Barrett's oesophagus develop over time in patients with chronic gastro-oesophageal reflux disease?
Aliment Pharmacol Ther 2007; 25(1):83-91AP

Abstract

BACKGROUND

Barrett's oesophagus is present in 8-10% of patients with gastro-oesophageal reflux disease (GERD).

AIM

We performed a cohort study to determine the incidence of Barrett's oesophagus in patients with chronic heartburn symptoms.

METHODS

We identified patients, with GERD and/or Barrett's oesophagus between 1998 and 2004 by primary or secondary International Classification of Diseases (ICD-9) codes of 530.81 and/or 530.2, who had two or more oesophagogastroduodenoscopies performed at least 6 months apart.

RESULTS

We screened 11 040 patients (41 390 random data entries by ICD-9 code) and enrolled 515 (4.6%) GERD patients and 169 (1.5%) Barrett's oesophagus patients. The mean (+/-s.d.) number of oesophagogastroduodenoscopies in the GERD cohort was 3.2 +/- 1.8 (range: 2-15) over 3.4 +/- 2.2 (range: 0.5-11) years. None of the 412 (80%) GERD patients with non-erosive disease developed Barrett's oesophagus over a mean follow-up time of 3.4 +/- 2.2 years (95% CI: 0-0.9%). Five (1%) of the 103 GERD patients with erosive oesophagitis developed subsequent Barrett's oesophagus. Fifty-seven per cent of the GERD patients were on PPI therapy at the time of index endoscopy. None of the 169 Barrett's oesophagus patients had normal index oesophagogastroduodenoscopies within a mean retrospective time period of 4.5 +/- 2.8 years (95% CI: 0-2%). Using the ICD-9 code of 530.2 as a predictor of the presence of Barrett's oesophagus, the sensitivity was 79% with a specificity of 88%.

CONCLUSION

The majority of patients with GERD do not appear to develop Barrett's oesophagus when it is not present on the index endoscopy.

Authors+Show Affiliations

Department of Medicine and Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17229223

Citation

Stoltey, J, et al. "Does Barrett's Oesophagus Develop Over Time in Patients With Chronic Gastro-oesophageal Reflux Disease?" Alimentary Pharmacology & Therapeutics, vol. 25, no. 1, 2007, pp. 83-91.
Stoltey J, Reeba H, Ullah N, et al. Does Barrett's oesophagus develop over time in patients with chronic gastro-oesophageal reflux disease? Aliment Pharmacol Ther. 2007;25(1):83-91.
Stoltey, J., Reeba, H., Ullah, N., Sabhaie, P., & Gerson, L. (2007). Does Barrett's oesophagus develop over time in patients with chronic gastro-oesophageal reflux disease? Alimentary Pharmacology & Therapeutics, 25(1), pp. 83-91.
Stoltey J, et al. Does Barrett's Oesophagus Develop Over Time in Patients With Chronic Gastro-oesophageal Reflux Disease. Aliment Pharmacol Ther. 2007 Jan 1;25(1):83-91. PubMed PMID: 17229223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does Barrett's oesophagus develop over time in patients with chronic gastro-oesophageal reflux disease? AU - Stoltey,J, AU - Reeba,H, AU - Ullah,N, AU - Sabhaie,P, AU - Gerson,L, PY - 2007/1/19/pubmed PY - 2007/6/30/medline PY - 2007/1/19/entrez SP - 83 EP - 91 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 25 IS - 1 N2 - BACKGROUND: Barrett's oesophagus is present in 8-10% of patients with gastro-oesophageal reflux disease (GERD). AIM: We performed a cohort study to determine the incidence of Barrett's oesophagus in patients with chronic heartburn symptoms. METHODS: We identified patients, with GERD and/or Barrett's oesophagus between 1998 and 2004 by primary or secondary International Classification of Diseases (ICD-9) codes of 530.81 and/or 530.2, who had two or more oesophagogastroduodenoscopies performed at least 6 months apart. RESULTS: We screened 11 040 patients (41 390 random data entries by ICD-9 code) and enrolled 515 (4.6%) GERD patients and 169 (1.5%) Barrett's oesophagus patients. The mean (+/-s.d.) number of oesophagogastroduodenoscopies in the GERD cohort was 3.2 +/- 1.8 (range: 2-15) over 3.4 +/- 2.2 (range: 0.5-11) years. None of the 412 (80%) GERD patients with non-erosive disease developed Barrett's oesophagus over a mean follow-up time of 3.4 +/- 2.2 years (95% CI: 0-0.9%). Five (1%) of the 103 GERD patients with erosive oesophagitis developed subsequent Barrett's oesophagus. Fifty-seven per cent of the GERD patients were on PPI therapy at the time of index endoscopy. None of the 169 Barrett's oesophagus patients had normal index oesophagogastroduodenoscopies within a mean retrospective time period of 4.5 +/- 2.8 years (95% CI: 0-2%). Using the ICD-9 code of 530.2 as a predictor of the presence of Barrett's oesophagus, the sensitivity was 79% with a specificity of 88%. CONCLUSION: The majority of patients with GERD do not appear to develop Barrett's oesophagus when it is not present on the index endoscopy. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/17229223/Does_Barrett's_oesophagus_develop_over_time_in_patients_with_chronic_gastro_oesophageal_reflux_disease L2 - https://doi.org/10.1111/j.1365-2036.2006.03138.x DB - PRIME DP - Unbound Medicine ER -