Tags

Type your tag names separated by a space and hit enter

Molecular control of iron transport.
J Am Soc Nephrol. 2007 Feb; 18(2):394-400.JA

Abstract

The iron-regulatory hormone hepcidin is a 25-amino acid peptide that is synthesized in hepatocytes. Hepcidin binds to the cellular iron export channel ferroportin and causes its internalization and degradation and thereby decreases iron efflux from iron exporting tissues into plasma. By this mechanism, hepcidin inhibits dietary iron absorption, the efflux of recycled iron from splenic and hepatic macrophages, and the release of iron from storage in hepatocytes. Hepcidin synthesis is stimulated by plasma iron and iron stores and is inhibited by erythropoietic activity, ensuring that extracellular plasma iron concentrations and iron stores remain stable and the erythropoietic demand for iron is met. During inflammation, increased hepcidin concentrations cause iron sequestration in macrophages, resulting in hypoferremia and eventually anemia of inflammation. Hepcidin deficiency plays a central role in most iron overload disorders. The role of hepcidin abnormalities in anemias that are associated with renal disease and in resistance to erythropoietic therapies remains to be elucidated.

Authors+Show Affiliations

Departments of Medicine and Pathology, David Geffen School of Medicine, 10833 Le Conte Avenue, CHS 37-055, University of California, Los Angeles, CA 90095-1690, USA. tganz@mednet.ucla.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17229910

Citation

Ganz, Tomas. "Molecular Control of Iron Transport." Journal of the American Society of Nephrology : JASN, vol. 18, no. 2, 2007, pp. 394-400.
Ganz T. Molecular control of iron transport. J Am Soc Nephrol. 2007;18(2):394-400.
Ganz, T. (2007). Molecular control of iron transport. Journal of the American Society of Nephrology : JASN, 18(2), 394-400.
Ganz T. Molecular Control of Iron Transport. J Am Soc Nephrol. 2007;18(2):394-400. PubMed PMID: 17229910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular control of iron transport. A1 - Ganz,Tomas, Y1 - 2007/01/17/ PY - 2007/1/19/pubmed PY - 2007/4/11/medline PY - 2007/1/19/entrez SP - 394 EP - 400 JF - Journal of the American Society of Nephrology : JASN JO - J Am Soc Nephrol VL - 18 IS - 2 N2 - The iron-regulatory hormone hepcidin is a 25-amino acid peptide that is synthesized in hepatocytes. Hepcidin binds to the cellular iron export channel ferroportin and causes its internalization and degradation and thereby decreases iron efflux from iron exporting tissues into plasma. By this mechanism, hepcidin inhibits dietary iron absorption, the efflux of recycled iron from splenic and hepatic macrophages, and the release of iron from storage in hepatocytes. Hepcidin synthesis is stimulated by plasma iron and iron stores and is inhibited by erythropoietic activity, ensuring that extracellular plasma iron concentrations and iron stores remain stable and the erythropoietic demand for iron is met. During inflammation, increased hepcidin concentrations cause iron sequestration in macrophages, resulting in hypoferremia and eventually anemia of inflammation. Hepcidin deficiency plays a central role in most iron overload disorders. The role of hepcidin abnormalities in anemias that are associated with renal disease and in resistance to erythropoietic therapies remains to be elucidated. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/17229910/Molecular_control_of_iron_transport_ L2 - https://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=17229910 DB - PRIME DP - Unbound Medicine ER -