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Apolipoprotein E epsilon4 allele is associated with Parkinson disease risk in a Mexican Mestizo population.
Mov Disord. 2007 Feb 15; 22(3):417-20.MD

Abstract

We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE-epsilon4 allele and APOE epsilon4/epsilon3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025).

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Authors+Show Affiliations

López M
Department of Biological Systems, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico.
Guerrero J
No affiliation info available
Yescas P
No affiliation info available
Boll MC
No affiliation info available
Familiar I
No affiliation info available
Ochoa A
No affiliation info available
Rasmussen A
No affiliation info available
Alonso ME
No affiliation info available

MeSH

Age of OnsetAgedApolipoprotein E4FemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMexicoMiddle AgedParkinson DiseaseRisk

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17230455

Citation

López, Marisol, et al. "Apolipoprotein E Epsilon4 Allele Is Associated With Parkinson Disease Risk in a Mexican Mestizo Population." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 22, no. 3, 2007, pp. 417-20.
López M, Guerrero J, Yescas P, et al. Apolipoprotein E epsilon4 allele is associated with Parkinson disease risk in a Mexican Mestizo population. Mov Disord. 2007;22(3):417-20.
López, M., Guerrero, J., Yescas, P., Boll, M. C., Familiar, I., Ochoa, A., Rasmussen, A., & Alonso, M. E. (2007). Apolipoprotein E epsilon4 allele is associated with Parkinson disease risk in a Mexican Mestizo population. Movement Disorders : Official Journal of the Movement Disorder Society, 22(3), 417-20.
López M, et al. Apolipoprotein E Epsilon4 Allele Is Associated With Parkinson Disease Risk in a Mexican Mestizo Population. Mov Disord. 2007 Feb 15;22(3):417-20. PubMed PMID: 17230455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E epsilon4 allele is associated with Parkinson disease risk in a Mexican Mestizo population. AU - López,Marisol, AU - Guerrero,Jorge, AU - Yescas,Petra, AU - Boll,Marie-Catherine, AU - Familiar,Itziar, AU - Ochoa,Adriana, AU - Rasmussen,Astrid, AU - Alonso,María Elisa, PY - 2007/1/19/pubmed PY - 2007/5/2/medline PY - 2007/1/19/entrez SP - 417 EP - 20 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 22 IS - 3 N2 - We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE-epsilon4 allele and APOE epsilon4/epsilon3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025). SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/17230455/Apolipoprotein_E_epsilon4_allele_is_associated_with_Parkinson_disease_risk_in_a_Mexican_Mestizo_population_ L2 - https://doi.org/10.1002/mds.21340 DB - PRIME DP - Unbound Medicine ER -