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Anatomical subsite discrepancy in relation to the impact of the consumption of alcohol, tobacco and betel quid on esophageal cancer.
Int J Cancer. 2007 Apr 15; 120(8):1755-62.IJ

Abstract

The carcinogenetic impact of risk factors on esophageal cancer (EC) may differ according to the portion of the esophagus where the tumor occurs. It is unclear why more esophageal squamous cell carcinomas (SCC) developed in the middle location. We carried out a multicenter case-control study in Taiwan to assess anatomical subsite risk discrepancy for this neoplasm in regard to the consumption of alcohol, tobacco and betel quid. Four hundred forty seven incident patients with pathology-proven SCC of the esophagus (107 were upper-third [U/3-EC], 199 middle-third [M/3-EC] and 141 lower-third [L/3-EC] cases), as well as 1,022 gender, age and study hospital matched controls were analyzed by unordered polytomous logistic regression. All consumption of the three substances was related to the development of each subsite of EC, with a heterogeneously higher risk for current smokers (adjusted odds ratio (AOR) = 6.2) found in M/3-EC and for current chewers, in U/3-EC (AOR = 4.9). The joint risk of contracting lower two-third EC for drinking and smoking appeared to significantly surpass those estimated by a multiplicative interaction model. Concomitant exposure to these two agents brought the risks of EC at all three subsites up to 10- to 23.9-fold and additional tobacco-free betel quid to a 30.3- to 75.0-fold. In conclusion, tumor subsite discrepancy risk is related to prolonged exposure to tobacco and betel quid with inflorescence. Alcohol interacts with tobacco in a stronger supra-multiplicative way in the middle portion of the esophagus, probably explaining why esophageal SCC occurs more commonly at this anatomical location.

Authors+Show Affiliations

Graduate Institute of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17230518

Citation

Lee, Chien-Hung, et al. "Anatomical Subsite Discrepancy in Relation to the Impact of the Consumption of Alcohol, Tobacco and Betel Quid On Esophageal Cancer." International Journal of Cancer, vol. 120, no. 8, 2007, pp. 1755-62.
Lee CH, Wu DC, Lee JM, et al. Anatomical subsite discrepancy in relation to the impact of the consumption of alcohol, tobacco and betel quid on esophageal cancer. Int J Cancer. 2007;120(8):1755-62.
Lee, C. H., Wu, D. C., Lee, J. M., Wu, I. C., Goan, Y. G., Kao, E. L., Huang, H. L., Chan, T. F., Chou, S. H., Chou, Y. P., Ho, C. K., & Wu, M. T. (2007). Anatomical subsite discrepancy in relation to the impact of the consumption of alcohol, tobacco and betel quid on esophageal cancer. International Journal of Cancer, 120(8), 1755-62.
Lee CH, et al. Anatomical Subsite Discrepancy in Relation to the Impact of the Consumption of Alcohol, Tobacco and Betel Quid On Esophageal Cancer. Int J Cancer. 2007 Apr 15;120(8):1755-62. PubMed PMID: 17230518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anatomical subsite discrepancy in relation to the impact of the consumption of alcohol, tobacco and betel quid on esophageal cancer. AU - Lee,Chien-Hung, AU - Wu,Deng-Chyang, AU - Lee,Jang-Ming, AU - Wu,I-Chen, AU - Goan,Yih-Gang, AU - Kao,Ein-Long, AU - Huang,Hsiao-Ling, AU - Chan,Te-Fu, AU - Chou,Shah-Hwa, AU - Chou,Yi-Pin, AU - Ho,Chi-Kung, AU - Wu,Ming-Tsang, PY - 2007/1/19/pubmed PY - 2007/4/18/medline PY - 2007/1/19/entrez SP - 1755 EP - 62 JF - International journal of cancer JO - Int J Cancer VL - 120 IS - 8 N2 - The carcinogenetic impact of risk factors on esophageal cancer (EC) may differ according to the portion of the esophagus where the tumor occurs. It is unclear why more esophageal squamous cell carcinomas (SCC) developed in the middle location. We carried out a multicenter case-control study in Taiwan to assess anatomical subsite risk discrepancy for this neoplasm in regard to the consumption of alcohol, tobacco and betel quid. Four hundred forty seven incident patients with pathology-proven SCC of the esophagus (107 were upper-third [U/3-EC], 199 middle-third [M/3-EC] and 141 lower-third [L/3-EC] cases), as well as 1,022 gender, age and study hospital matched controls were analyzed by unordered polytomous logistic regression. All consumption of the three substances was related to the development of each subsite of EC, with a heterogeneously higher risk for current smokers (adjusted odds ratio (AOR) = 6.2) found in M/3-EC and for current chewers, in U/3-EC (AOR = 4.9). The joint risk of contracting lower two-third EC for drinking and smoking appeared to significantly surpass those estimated by a multiplicative interaction model. Concomitant exposure to these two agents brought the risks of EC at all three subsites up to 10- to 23.9-fold and additional tobacco-free betel quid to a 30.3- to 75.0-fold. In conclusion, tumor subsite discrepancy risk is related to prolonged exposure to tobacco and betel quid with inflorescence. Alcohol interacts with tobacco in a stronger supra-multiplicative way in the middle portion of the esophagus, probably explaining why esophageal SCC occurs more commonly at this anatomical location. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/17230518/Anatomical_subsite_discrepancy_in_relation_to_the_impact_of_the_consumption_of_alcohol_tobacco_and_betel_quid_on_esophageal_cancer_ L2 - https://doi.org/10.1002/ijc.22324 DB - PRIME DP - Unbound Medicine ER -