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[Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia].
Rinsho Ketsueki. 2006 Dec; 47(12):1533-8.RK

Abstract

Superior sagittal sinus thrombosis (SSST) has been reported to be caused by coagulopathy following oral contraceptive therapy, DIC, infection around the sinus, compression from a tumor, infiltration of tumor, and an inherited deficiency of proteins C and S, but SSST associated with hematological malignancies and L-asparaginase (L-Asp) therapy is rare. We report a case of an adult patient with acute lymphoblastic leukemia (ALL) who developed SSST during the remission induction therapy. A 25-year-old man was admitted with left facial nerve palsy and, following bone marrow aspiration and lumbar puncture, he was diagnosed as having T-ALL with CNS involvement. He received a 1-AdVP regimen as remission induction therapy and intrathecal administration of methotrexate and cytarabine. On day 29, he had a generalized convulsion and SSST was demonstrated by imaging tests. Lymphoid malignancy (ALL in particular), the use of L-Asp, CNS involvement, and intrathecal chemotherapy might be risk factors for the occurrence SSST. When a patient with those factors develops any neurological symptoms, we should pay attention to the occurrence of SSST, as well as stroke or CNS involvement, though SSST is rare.

Authors+Show Affiliations

Division of Hematology, NTT Kanto Medical Center.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

17233472

Citation

Yoshimi, Akihide, et al. "[Superior Sagittal Sinus Thrombosis During Remission Induction Therapy for Acute Lymphoblastic Leukemia]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 47, no. 12, 2006, pp. 1533-8.
Yoshimi A, Taoka K, Nakasone H, et al. [Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia]. Rinsho Ketsueki. 2006;47(12):1533-8.
Yoshimi, A., Taoka, K., Nakasone, H., Iijima, K., Kida, M., Iki, S., Urabe, A., & Usuki, K. (2006). [Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 47(12), 1533-8.
Yoshimi A, et al. [Superior Sagittal Sinus Thrombosis During Remission Induction Therapy for Acute Lymphoblastic Leukemia]. Rinsho Ketsueki. 2006;47(12):1533-8. PubMed PMID: 17233472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia]. AU - Yoshimi,Akihide, AU - Taoka,Kazuki, AU - Nakasone,Hideki, AU - Iijima,Kimiko, AU - Kida,Michiko, AU - Iki,Seiko, AU - Urabe,Akio, AU - Usuki,Kensuke, PY - 2007/1/20/pubmed PY - 2007/2/28/medline PY - 2007/1/20/entrez SP - 1533 EP - 8 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 47 IS - 12 N2 - Superior sagittal sinus thrombosis (SSST) has been reported to be caused by coagulopathy following oral contraceptive therapy, DIC, infection around the sinus, compression from a tumor, infiltration of tumor, and an inherited deficiency of proteins C and S, but SSST associated with hematological malignancies and L-asparaginase (L-Asp) therapy is rare. We report a case of an adult patient with acute lymphoblastic leukemia (ALL) who developed SSST during the remission induction therapy. A 25-year-old man was admitted with left facial nerve palsy and, following bone marrow aspiration and lumbar puncture, he was diagnosed as having T-ALL with CNS involvement. He received a 1-AdVP regimen as remission induction therapy and intrathecal administration of methotrexate and cytarabine. On day 29, he had a generalized convulsion and SSST was demonstrated by imaging tests. Lymphoid malignancy (ALL in particular), the use of L-Asp, CNS involvement, and intrathecal chemotherapy might be risk factors for the occurrence SSST. When a patient with those factors develops any neurological symptoms, we should pay attention to the occurrence of SSST, as well as stroke or CNS involvement, though SSST is rare. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/17233472/[Superior_sagittal_sinus_thrombosis_during_remission_induction_therapy_for_acute_lymphoblastic_leukemia]_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/rinketsu/47.1533?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -