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Is FLT3 internal tandem duplication significant indicator for allogeneic transplantation in acute myeloid leukemia? An analysis of patients from the Czech Acute Leukemia Clinical Register (ALERT).
Neoplasma. 2007; 54(1):89-94.N

Abstract

To assess the prognostic relevance of activating mutations of FLT3 gene on outcome of allogeneic transplantations in AML patients, we performed an analysis of all patients with FLT3 mutations registered in the Czech Acute Leukemia Clinical Register (ALERT) from 2003 till the end of 2005. Within the mentioned period 170 patients with AML of median age 56 years (23-77) were investigated for FLT3 mutation, within them 36 cases (21%) with FLT3 mutations (32 FLT3 ITD and 4 FLT3 D835) were found. Out of FLT3 ITD positive patients 13 had allogeneic transplantation, 20 patients with mutations of FLT3 were treated with chemotherapy without transplantation. Results of the treatment of these patients were compared with the results of the group of patients without FLT3 mutation, which was according to other characteristics identical with the group of patients with FLT3 mutations (n=134). Median overall survival (OS) was significantly shorter for patients with FLT3 ITD (34.8 weeks) than for those without FLT3 mutations (67.7 weeks; P=0.028). Median OS of patients with FLT3 ITD who had allogeneic transplantation was 42.5 weeks; median OS of patients with FLT3 ITD treated only with chemotherapy was 29.6 weeks (P=0.362). After allogeneic transplantation, median OS of FLT3 mutations negative patients was similar to FLT3 ITD positive patients (46.7 versus 42.5 weeks; P=0.443). Our results suggest that at present there is no strong evidence that FLT3 status alone should influence the decision to proceed to allogeneic transplantation in AML patients. Decision to proceed to alogeneic transplantation should not be based on the FLT3 status only, but it should also consider other prognostic factors.

Authors+Show Affiliations

Department of Internal Medicine-Hematooncology, Masaryk University Hospital Brno, Czech Republic. mdoubek@fnbrno.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17233551

Citation

Doubek, M, et al. "Is FLT3 Internal Tandem Duplication Significant Indicator for Allogeneic Transplantation in Acute Myeloid Leukemia? an Analysis of Patients From the Czech Acute Leukemia Clinical Register (ALERT)." Neoplasma, vol. 54, no. 1, 2007, pp. 89-94.
Doubek M, Muzík J, Szotkowski T, et al. Is FLT3 internal tandem duplication significant indicator for allogeneic transplantation in acute myeloid leukemia? An analysis of patients from the Czech Acute Leukemia Clinical Register (ALERT). Neoplasma. 2007;54(1):89-94.
Doubek, M., Muzík, J., Szotkowski, T., Koza, V., Cetkovský, P., Kozák, T., Zák, P., Voglová, J., Struncová, S., Dusek, L., & Indrák, K. (2007). Is FLT3 internal tandem duplication significant indicator for allogeneic transplantation in acute myeloid leukemia? An analysis of patients from the Czech Acute Leukemia Clinical Register (ALERT). Neoplasma, 54(1), 89-94.
Doubek M, et al. Is FLT3 Internal Tandem Duplication Significant Indicator for Allogeneic Transplantation in Acute Myeloid Leukemia? an Analysis of Patients From the Czech Acute Leukemia Clinical Register (ALERT). Neoplasma. 2007;54(1):89-94. PubMed PMID: 17233551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is FLT3 internal tandem duplication significant indicator for allogeneic transplantation in acute myeloid leukemia? An analysis of patients from the Czech Acute Leukemia Clinical Register (ALERT). AU - Doubek,M, AU - Muzík,J, AU - Szotkowski,T, AU - Koza,V, AU - Cetkovský,P, AU - Kozák,T, AU - Zák,P, AU - Voglová,J, AU - Struncová,S, AU - Dusek,L, AU - Indrák,K, PY - 2007/1/20/pubmed PY - 2007/6/28/medline PY - 2007/1/20/entrez SP - 89 EP - 94 JF - Neoplasma JO - Neoplasma VL - 54 IS - 1 N2 - To assess the prognostic relevance of activating mutations of FLT3 gene on outcome of allogeneic transplantations in AML patients, we performed an analysis of all patients with FLT3 mutations registered in the Czech Acute Leukemia Clinical Register (ALERT) from 2003 till the end of 2005. Within the mentioned period 170 patients with AML of median age 56 years (23-77) were investigated for FLT3 mutation, within them 36 cases (21%) with FLT3 mutations (32 FLT3 ITD and 4 FLT3 D835) were found. Out of FLT3 ITD positive patients 13 had allogeneic transplantation, 20 patients with mutations of FLT3 were treated with chemotherapy without transplantation. Results of the treatment of these patients were compared with the results of the group of patients without FLT3 mutation, which was according to other characteristics identical with the group of patients with FLT3 mutations (n=134). Median overall survival (OS) was significantly shorter for patients with FLT3 ITD (34.8 weeks) than for those without FLT3 mutations (67.7 weeks; P=0.028). Median OS of patients with FLT3 ITD who had allogeneic transplantation was 42.5 weeks; median OS of patients with FLT3 ITD treated only with chemotherapy was 29.6 weeks (P=0.362). After allogeneic transplantation, median OS of FLT3 mutations negative patients was similar to FLT3 ITD positive patients (46.7 versus 42.5 weeks; P=0.443). Our results suggest that at present there is no strong evidence that FLT3 status alone should influence the decision to proceed to allogeneic transplantation in AML patients. Decision to proceed to alogeneic transplantation should not be based on the FLT3 status only, but it should also consider other prognostic factors. SN - 0028-2685 UR - https://www.unboundmedicine.com/medline/citation/17233551/Is_FLT3_internal_tandem_duplication_significant_indicator_for_allogeneic_transplantation_in_acute_myeloid_leukemia_An_analysis_of_patients_from_the_Czech_Acute_Leukemia_Clinical_Register__ALERT__ L2 - http://www.aepress.sk/_downloads/dl.php?from=pubmed&journal=NEO&file=2007_01_89.pdf DB - PRIME DP - Unbound Medicine ER -