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Quality of erection questionnaire correlates: change in erection quality with erectile function, hardness, and psychosocial measures in men treated with sildenafil for erectile dysfunction.
J Sex Med. 2007 Jan; 4(1):83-92.JS

Abstract

INTRODUCTION

The validated Quality of Erection Questionnaire (QEQ) is a six-question, patient-reported outcome measure for comprehensively evaluating satisfaction with the quality of erections in terms of hardness, onset, and duration, which can be used to develop and monitor individualized treatment goals.

AIMS

To further validate the QEQ by determining responsiveness/sensitivity to change in erectile function, erection hardness grade, and psychosocial outcomes in men treated with sildenafil for erectile dysfunction (ED).

METHODS

This open-label, noncomparative, multicenter trial of sildenafil (50 or 100 mg as needed for 10 weeks) enrolled men with ED who were in a stable, sexual relationship for at least 6 months. Previous phosphodiesterase type 5 inhibitor use must have been no more than 6 doses ever and no doses more recently than the previous 4 weeks.

MAIN OUTCOME MEASURES

The baseline to week 10 change in the QEQ total score and its correlations with the end-of-treatment Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) score and with changes in: (i) International Index of Erectile Function (IIEF) domain scores; (ii) Self-Esteem And Relationship (SEAR) questionnaire component scores; and (iii) the frequency of erections graded hard enough for penetration (grade 3) or completely hard (grade 4) on the event log Erectile Hardness Grading Scale.

RESULTS

The mean +/- standard deviation transformed QEQ total score tripled from 22.0 +/- 21.1 to 69.9 +/- 35.9 (P < 0.0001), and correlated positively with the end-of-treatment EDITS index score (r = 0.71) and with changes in IIEF domain scores (r = 0.29-0.86), SEAR component scores (r = 0.37-0.78), and the percentage of occasions that grade 3 or 4 erections were achieved (r = 0.66).

CONCLUSIONS

The brief, easy-to-administer QEQ is responsive to the benefits of sildenafil treatment of men for ED and has convergent validity with measures of clinical and psychosocial outcomes.

Authors+Show Affiliations

Australian Centre for Sexual Health, Bondi Junction, Australia;. Electronic address: mlowy@bigpond.net.au.Pfizer Inc., New York, NY.Holdsworth House Medical Practice, Darlihnghurst, NSW, Australia.Health Institute for Men, Brisbane, Australia.Melbourne Andrology Centre, Melbourne, Australia.Royal Adelaide Hospital, Adelaide, Australia.Pfizer Inc., New York, NY.Pfizer Inc., New York, NY.

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

17233777

Citation

Lowy, Michael, et al. "Quality of Erection Questionnaire Correlates: Change in Erection Quality With Erectile Function, Hardness, and Psychosocial Measures in Men Treated With Sildenafil for Erectile Dysfunction." The Journal of Sexual Medicine, vol. 4, no. 1, 2007, pp. 83-92.
Lowy M, Collins S, Bloch M, et al. Quality of erection questionnaire correlates: change in erection quality with erectile function, hardness, and psychosocial measures in men treated with sildenafil for erectile dysfunction. J Sex Med. 2007;4(1):83-92.
Lowy, M., Collins, S., Bloch, M., Gillman, M., Lording, D., Sutherland, P., Wang, H., & Stecher, V. (2007). Quality of erection questionnaire correlates: change in erection quality with erectile function, hardness, and psychosocial measures in men treated with sildenafil for erectile dysfunction. The Journal of Sexual Medicine, 4(1), 83-92. https://doi.org/10.1111/j.1743-6109.2006.00398.x
Lowy M, et al. Quality of Erection Questionnaire Correlates: Change in Erection Quality With Erectile Function, Hardness, and Psychosocial Measures in Men Treated With Sildenafil for Erectile Dysfunction. J Sex Med. 2007;4(1):83-92. PubMed PMID: 17233777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quality of erection questionnaire correlates: change in erection quality with erectile function, hardness, and psychosocial measures in men treated with sildenafil for erectile dysfunction. AU - Lowy,Michael, AU - Collins,Suzanne, AU - Bloch,Mark, AU - Gillman,Michael, AU - Lording,Douglas, AU - Sutherland,Peter, AU - Wang,Hao, AU - Stecher,Vera, PY - 2007/1/20/pubmed PY - 2007/3/22/medline PY - 2007/1/20/entrez SP - 83 EP - 92 JF - The journal of sexual medicine JO - J Sex Med VL - 4 IS - 1 N2 - INTRODUCTION: The validated Quality of Erection Questionnaire (QEQ) is a six-question, patient-reported outcome measure for comprehensively evaluating satisfaction with the quality of erections in terms of hardness, onset, and duration, which can be used to develop and monitor individualized treatment goals. AIMS: To further validate the QEQ by determining responsiveness/sensitivity to change in erectile function, erection hardness grade, and psychosocial outcomes in men treated with sildenafil for erectile dysfunction (ED). METHODS: This open-label, noncomparative, multicenter trial of sildenafil (50 or 100 mg as needed for 10 weeks) enrolled men with ED who were in a stable, sexual relationship for at least 6 months. Previous phosphodiesterase type 5 inhibitor use must have been no more than 6 doses ever and no doses more recently than the previous 4 weeks. MAIN OUTCOME MEASURES: The baseline to week 10 change in the QEQ total score and its correlations with the end-of-treatment Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) score and with changes in: (i) International Index of Erectile Function (IIEF) domain scores; (ii) Self-Esteem And Relationship (SEAR) questionnaire component scores; and (iii) the frequency of erections graded hard enough for penetration (grade 3) or completely hard (grade 4) on the event log Erectile Hardness Grading Scale. RESULTS: The mean +/- standard deviation transformed QEQ total score tripled from 22.0 +/- 21.1 to 69.9 +/- 35.9 (P < 0.0001), and correlated positively with the end-of-treatment EDITS index score (r = 0.71) and with changes in IIEF domain scores (r = 0.29-0.86), SEAR component scores (r = 0.37-0.78), and the percentage of occasions that grade 3 or 4 erections were achieved (r = 0.66). CONCLUSIONS: The brief, easy-to-administer QEQ is responsive to the benefits of sildenafil treatment of men for ED and has convergent validity with measures of clinical and psychosocial outcomes. SN - 1743-6095 UR - https://www.unboundmedicine.com/medline/citation/17233777/Quality_of_erection_questionnaire_correlates:_change_in_erection_quality_with_erectile_function_hardness_and_psychosocial_measures_in_men_treated_with_sildenafil_for_erectile_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-6095(15)31498-3 DB - PRIME DP - Unbound Medicine ER -