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CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease.
Clin Immunol. 2007 Apr; 123(1):50-9.CI

Abstract

CD4(+)CD25(+) regulatory T cells (Treg) play a central role in the prevention of autoimmunity and in the control of immune responses by down-regulating the function of effector CD4(+) or CD8(+) T cells. The role of Treg in Mycobacterium tuberculosis infection and persistence is inadequately documented. Therefore, the current study was designed to determine whether CD4(+)CD25(+)FoxP3(+) regulatory T cells may modulate immunity against human tuberculosis (TB). Our results indicate that the number of CD4(+)CD25(+)FoxP3(+) Treg increases in the blood or at the site of infection in active TB patients. The frequency of CD4(+)CD25(+)FoxP3(+) Treg in pleural fluid inversely correlates with local MTB-specific immunity (p<0.002). These CD4(+)CD25(+)FoxP3(+) T lymphocytes isolated from the blood and pleural fluid are capable of suppressing MTB-specific IFN-gamma and IL-10 production in TB patients. Therefore, CD4(+)CD25(+)FoxP3(+) Treg expanded in TB patients suppress M. tuberculosis immunity and may therefore contribute to the pathogenesis of human TB.

Authors+Show Affiliations

Shenzhen Donghu Hospital, 2019, Buxin Road, Shenzhen 518020, China. chenxinchun@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17234458

Citation

Chen, Xinchun, et al. "CD4(+)CD25(+)FoxP3(+) Regulatory T Cells Suppress Mycobacterium Tuberculosis Immunity in Patients With Active Disease." Clinical Immunology (Orlando, Fla.), vol. 123, no. 1, 2007, pp. 50-9.
Chen X, Zhou B, Li M, et al. CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease. Clin Immunol. 2007;123(1):50-9.
Chen, X., Zhou, B., Li, M., Deng, Q., Wu, X., Le, X., Wu, C., Larmonier, N., Zhang, W., Zhang, H., Wang, H., & Katsanis, E. (2007). CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease. Clinical Immunology (Orlando, Fla.), 123(1), 50-9.
Chen X, et al. CD4(+)CD25(+)FoxP3(+) Regulatory T Cells Suppress Mycobacterium Tuberculosis Immunity in Patients With Active Disease. Clin Immunol. 2007;123(1):50-9. PubMed PMID: 17234458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease. AU - Chen,Xinchun, AU - Zhou,Boping, AU - Li,Meizhong, AU - Deng,Qunyi, AU - Wu,Xueqiong, AU - Le,Xiaohua, AU - Wu,Chi, AU - Larmonier,Nicolas, AU - Zhang,Wei, AU - Zhang,Hongmei, AU - Wang,Huosheng, AU - Katsanis,Emmanuel, Y1 - 2007/01/17/ PY - 2006/09/19/received PY - 2006/11/08/revised PY - 2006/11/20/accepted PY - 2007/1/20/pubmed PY - 2007/5/5/medline PY - 2007/1/20/entrez SP - 50 EP - 9 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 123 IS - 1 N2 - CD4(+)CD25(+) regulatory T cells (Treg) play a central role in the prevention of autoimmunity and in the control of immune responses by down-regulating the function of effector CD4(+) or CD8(+) T cells. The role of Treg in Mycobacterium tuberculosis infection and persistence is inadequately documented. Therefore, the current study was designed to determine whether CD4(+)CD25(+)FoxP3(+) regulatory T cells may modulate immunity against human tuberculosis (TB). Our results indicate that the number of CD4(+)CD25(+)FoxP3(+) Treg increases in the blood or at the site of infection in active TB patients. The frequency of CD4(+)CD25(+)FoxP3(+) Treg in pleural fluid inversely correlates with local MTB-specific immunity (p<0.002). These CD4(+)CD25(+)FoxP3(+) T lymphocytes isolated from the blood and pleural fluid are capable of suppressing MTB-specific IFN-gamma and IL-10 production in TB patients. Therefore, CD4(+)CD25(+)FoxP3(+) Treg expanded in TB patients suppress M. tuberculosis immunity and may therefore contribute to the pathogenesis of human TB. SN - 1521-6616 UR - https://www.unboundmedicine.com/medline/citation/17234458/CD4_+_CD25_+_FoxP3_+__regulatory_T_cells_suppress_Mycobacterium_tuberculosis_immunity_in_patients_with_active_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(06)00963-6 DB - PRIME DP - Unbound Medicine ER -