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Bioassay-guided isolation of antifungal alkaloids from Melochia odorata.
Phytother Res. 2007 Apr; 21(4):398-400.PR

Abstract

An alkaloidal extract of the leaves of Melochia odorata exhibited antifungal activity against Candida albicans, Cryptococcus neoformans and Saccharomyces cerevisiae using a TLC bioautographic method. Bioassay-guided fractionation of this extract using separation by normal and reverse high-performance liquid chromatography (HPLC) resulted in the isolation of two active compounds identified as frangulanine, a cyclic peptide alkaloid, and waltherione-A, a quinolinone alkaloid.

Authors+Show Affiliations

Laboratoire de Pharmacognosie UMR 8076 CNRS, Faculté de Pharmacie, Université Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry cedex, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17236172

Citation

Emile, Aurélie, et al. "Bioassay-guided Isolation of Antifungal Alkaloids From Melochia Odorata." Phytotherapy Research : PTR, vol. 21, no. 4, 2007, pp. 398-400.
Emile A, Waikedre J, Herrenknecht C, et al. Bioassay-guided isolation of antifungal alkaloids from Melochia odorata. Phytother Res. 2007;21(4):398-400.
Emile, A., Waikedre, J., Herrenknecht, C., Fourneau, C., Gantier, J. C., Hnawia, E., Cabalion, P., Hocquemiller, R., & Fournet, A. (2007). Bioassay-guided isolation of antifungal alkaloids from Melochia odorata. Phytotherapy Research : PTR, 21(4), 398-400.
Emile A, et al. Bioassay-guided Isolation of Antifungal Alkaloids From Melochia Odorata. Phytother Res. 2007;21(4):398-400. PubMed PMID: 17236172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioassay-guided isolation of antifungal alkaloids from Melochia odorata. AU - Emile,Aurélie, AU - Waikedre,Jean, AU - Herrenknecht,Christine, AU - Fourneau,Christophe, AU - Gantier,Jean-Charles, AU - Hnawia,Edouard, AU - Cabalion,Pierre, AU - Hocquemiller,Reynald, AU - Fournet,Alain, PY - 2007/1/20/pubmed PY - 2007/6/15/medline PY - 2007/1/20/entrez SP - 398 EP - 400 JF - Phytotherapy research : PTR JO - Phytother Res VL - 21 IS - 4 N2 - An alkaloidal extract of the leaves of Melochia odorata exhibited antifungal activity against Candida albicans, Cryptococcus neoformans and Saccharomyces cerevisiae using a TLC bioautographic method. Bioassay-guided fractionation of this extract using separation by normal and reverse high-performance liquid chromatography (HPLC) resulted in the isolation of two active compounds identified as frangulanine, a cyclic peptide alkaloid, and waltherione-A, a quinolinone alkaloid. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/17236172/Bioassay_guided_isolation_of_antifungal_alkaloids_from_Melochia_odorata_ L2 - https://doi.org/10.1002/ptr.2078 DB - PRIME DP - Unbound Medicine ER -