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Bioassay-guided isolation of antifungal alkaloids from Melochia odorata.
Phytother Res. 2007 Apr; 21(4):398-400.PR

Abstract

An alkaloidal extract of the leaves of Melochia odorata exhibited antifungal activity against Candida albicans, Cryptococcus neoformans and Saccharomyces cerevisiae using a TLC bioautographic method. Bioassay-guided fractionation of this extract using separation by normal and reverse high-performance liquid chromatography (HPLC) resulted in the isolation of two active compounds identified as frangulanine, a cyclic peptide alkaloid, and waltherione-A, a quinolinone alkaloid.

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Authors+Show Affiliations

Emile A
Laboratoire de Pharmacognosie UMR 8076 CNRS, Faculté de Pharmacie, Université Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry cedex, France.
Waikedre J
No affiliation info available
Herrenknecht C
No affiliation info available
Fourneau C
No affiliation info available
Gantier JC
No affiliation info available
Hnawia E
No affiliation info available
Cabalion P
No affiliation info available
Hocquemiller R
No affiliation info available
Fournet A
No affiliation info available

MeSH

AlkaloidsAntifungal AgentsCandida albicansCryptococcus neoformansMalvaceaeMicrobial Sensitivity TestsPlant LeavesSaccharomyces cerevisiae

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17236172

Citation

Emile, Aurélie, et al. "Bioassay-guided Isolation of Antifungal Alkaloids From Melochia Odorata." Phytotherapy Research : PTR, vol. 21, no. 4, 2007, pp. 398-400.
Emile A, Waikedre J, Herrenknecht C, et al. Bioassay-guided isolation of antifungal alkaloids from Melochia odorata. Phytother Res. 2007;21(4):398-400.
Emile, A., Waikedre, J., Herrenknecht, C., Fourneau, C., Gantier, J. C., Hnawia, E., Cabalion, P., Hocquemiller, R., & Fournet, A. (2007). Bioassay-guided isolation of antifungal alkaloids from Melochia odorata. Phytotherapy Research : PTR, 21(4), 398-400.
Emile A, et al. Bioassay-guided Isolation of Antifungal Alkaloids From Melochia Odorata. Phytother Res. 2007;21(4):398-400. PubMed PMID: 17236172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioassay-guided isolation of antifungal alkaloids from Melochia odorata. AU - Emile,Aurélie, AU - Waikedre,Jean, AU - Herrenknecht,Christine, AU - Fourneau,Christophe, AU - Gantier,Jean-Charles, AU - Hnawia,Edouard, AU - Cabalion,Pierre, AU - Hocquemiller,Reynald, AU - Fournet,Alain, PY - 2007/1/20/pubmed PY - 2007/6/15/medline PY - 2007/1/20/entrez SP - 398 EP - 400 JF - Phytotherapy research : PTR JO - Phytother Res VL - 21 IS - 4 N2 - An alkaloidal extract of the leaves of Melochia odorata exhibited antifungal activity against Candida albicans, Cryptococcus neoformans and Saccharomyces cerevisiae using a TLC bioautographic method. Bioassay-guided fractionation of this extract using separation by normal and reverse high-performance liquid chromatography (HPLC) resulted in the isolation of two active compounds identified as frangulanine, a cyclic peptide alkaloid, and waltherione-A, a quinolinone alkaloid. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/17236172/Bioassay_guided_isolation_of_antifungal_alkaloids_from_Melochia_odorata_ L2 - https://doi.org/10.1002/ptr.2078 DB - PRIME DP - Unbound Medicine ER -