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Preoperative C-reactive protein levels predict 9-month mortality after coronary artery bypass grafting surgery for the treatment of left main coronary artery stenosis.
Eur J Cardiothorac Surg. 2007 Apr; 31(4):685-90.EJ

Abstract

OBJECTIVE

Preprocedural levels of C-reactive protein predict mid-term mortality after percutaneous coronary intervention for the treatment of unprotected left main coronary artery stenosis. However, there are no data regarding the impact of C-reactive protein on mid-term mortality in patients with unprotected left main coronary artery stenosis treated with coronary artery bypass graft.

METHODS

The predictive value of preoperative C-reactive protein levels, leukocyte counts, and fibrinogen levels were evaluated in a series of 108 patients who underwent coronary artery bypass graft surgery at our Institution from 1st January 2002 to 31st April 2005. Patients were divided in two groups: Group 1 included patients with C-reactive protein levels in quartiles IV (C-reactive protein levels > or =1.22mg/dl) and Group 2 included patients with C-reactive protein levels in quartiles I+II+III.

RESULTS

At 9-month follow-up the rate of mortality was 25.9% in Group 1 and 4.9% in Group 2 (hazard ratio=5.86, 95% confidence intervals=1.71-20.03; p=0.005). In all patients who had cardiac mortality, C-reactive protein levels were >0.5mg/dl. In the multivariate analysis age >75 years, peripheral vascular disease and C-reactive protein quartiles were the only independent predictors of mortality.

CONCLUSIONS

Elevated preoperative levels of C-reactive protein indicate an increased risk of death after coronary artery bypass graft surgery for the treatment of unprotected left main coronary artery stenosis. Inflammatory risk assessment in patients with unprotected left main coronary artery stenosis provides incremental prognostic value for adequate preoperative patient stratification.

Authors+Show Affiliations

Department of Cardiology, Policlinico S Orsola, University of Bologna, Italy. tulliopalmerini@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17236785

Citation

Palmerini, Tullio, et al. "Preoperative C-reactive Protein Levels Predict 9-month Mortality After Coronary Artery Bypass Grafting Surgery for the Treatment of Left Main Coronary Artery Stenosis." European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery, vol. 31, no. 4, 2007, pp. 685-90.
Palmerini T, Marzocchi A, Marrozzini C, et al. Preoperative C-reactive protein levels predict 9-month mortality after coronary artery bypass grafting surgery for the treatment of left main coronary artery stenosis. Eur J Cardiothorac Surg. 2007;31(4):685-90.
Palmerini, T., Marzocchi, A., Marrozzini, C., Reggiani, L. B., Savini, C., Marinelli, G., Di Bartolomeo, R., & Branzi, A. (2007). Preoperative C-reactive protein levels predict 9-month mortality after coronary artery bypass grafting surgery for the treatment of left main coronary artery stenosis. European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery, 31(4), 685-90.
Palmerini T, et al. Preoperative C-reactive Protein Levels Predict 9-month Mortality After Coronary Artery Bypass Grafting Surgery for the Treatment of Left Main Coronary Artery Stenosis. Eur J Cardiothorac Surg. 2007;31(4):685-90. PubMed PMID: 17236785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preoperative C-reactive protein levels predict 9-month mortality after coronary artery bypass grafting surgery for the treatment of left main coronary artery stenosis. AU - Palmerini,Tullio, AU - Marzocchi,Antonio, AU - Marrozzini,Cinzia, AU - Reggiani,Letizia Bacchi, AU - Savini,Carlo, AU - Marinelli,Giuseppe, AU - Di Bartolomeo,Roberto, AU - Branzi,Angelo, Y1 - 2007/01/22/ PY - 2006/10/16/received PY - 2006/12/20/revised PY - 2006/12/22/accepted PY - 2007/1/24/pubmed PY - 2007/6/29/medline PY - 2007/1/24/entrez SP - 685 EP - 90 JF - European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery JO - Eur J Cardiothorac Surg VL - 31 IS - 4 N2 - OBJECTIVE: Preprocedural levels of C-reactive protein predict mid-term mortality after percutaneous coronary intervention for the treatment of unprotected left main coronary artery stenosis. However, there are no data regarding the impact of C-reactive protein on mid-term mortality in patients with unprotected left main coronary artery stenosis treated with coronary artery bypass graft. METHODS: The predictive value of preoperative C-reactive protein levels, leukocyte counts, and fibrinogen levels were evaluated in a series of 108 patients who underwent coronary artery bypass graft surgery at our Institution from 1st January 2002 to 31st April 2005. Patients were divided in two groups: Group 1 included patients with C-reactive protein levels in quartiles IV (C-reactive protein levels > or =1.22mg/dl) and Group 2 included patients with C-reactive protein levels in quartiles I+II+III. RESULTS: At 9-month follow-up the rate of mortality was 25.9% in Group 1 and 4.9% in Group 2 (hazard ratio=5.86, 95% confidence intervals=1.71-20.03; p=0.005). In all patients who had cardiac mortality, C-reactive protein levels were >0.5mg/dl. In the multivariate analysis age >75 years, peripheral vascular disease and C-reactive protein quartiles were the only independent predictors of mortality. CONCLUSIONS: Elevated preoperative levels of C-reactive protein indicate an increased risk of death after coronary artery bypass graft surgery for the treatment of unprotected left main coronary artery stenosis. Inflammatory risk assessment in patients with unprotected left main coronary artery stenosis provides incremental prognostic value for adequate preoperative patient stratification. SN - 1010-7940 UR - https://www.unboundmedicine.com/medline/citation/17236785/Preoperative_C_reactive_protein_levels_predict_9_month_mortality_after_coronary_artery_bypass_grafting_surgery_for_the_treatment_of_left_main_coronary_artery_stenosis_ L2 - https://academic.oup.com/ejcts/article-lookup/doi/10.1016/j.ejcts.2006.12.029 DB - PRIME DP - Unbound Medicine ER -