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Escitalopram prevents relapse of obsessive-compulsive disorder.
Eur Neuropsychopharmacol. 2007 May-Jun; 17(6-7):430-9.EN

Abstract

To examine the efficacy and tolerability of escitalopram in the prevention of relapse in patients with OCD, 468 patients with OCD were treated with open label escitalopram (10 mg or 20 mg) for 16 weeks, after which the 320 responders (Y-BOCS total score decrease > or =25%) were randomised to placebo or escitalopram (at the assigned dose) for 24 weeks double-blind treatment. The primary analysis (time to relapse) showed a significant advantage for escitalopram (p<0.001, log-rank test). The proportion of patients who relapsed was statistically significantly higher in the placebo group (52%) than in the escitalopram group (23%) (p<0.001, chi(2)-test). The risk of relapse was 2.74 times higher for placebo compared to escitalopram. Escitalopram was well tolerated and improvements in obsessive-compulsive symptoms reported during the open label period were sustained during the double-blind extension of treatment with active drug. These results demonstrate that escitalopram is effective for long-term treatment and relapse prevention in OCD.

Authors+Show Affiliations

Postgraduate Medical School, University of Hertfordshire, Hatfield, United Kingdom. naomi.fineberg@btinternet.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

17240120

Citation

Fineberg, Naomi A., et al. "Escitalopram Prevents Relapse of Obsessive-compulsive Disorder." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 17, no. 6-7, 2007, pp. 430-9.
Fineberg NA, Tonnoir B, Lemming O, et al. Escitalopram prevents relapse of obsessive-compulsive disorder. Eur Neuropsychopharmacol. 2007;17(6-7):430-9.
Fineberg, N. A., Tonnoir, B., Lemming, O., & Stein, D. J. (2007). Escitalopram prevents relapse of obsessive-compulsive disorder. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 17(6-7), 430-9.
Fineberg NA, et al. Escitalopram Prevents Relapse of Obsessive-compulsive Disorder. Eur Neuropsychopharmacol. 2007 May-Jun;17(6-7):430-9. PubMed PMID: 17240120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Escitalopram prevents relapse of obsessive-compulsive disorder. AU - Fineberg,Naomi A, AU - Tonnoir,Brigitte, AU - Lemming,Ole, AU - Stein,Dan J, Y1 - 2007/01/19/ PY - 2006/06/23/received PY - 2006/11/24/revised PY - 2006/11/29/accepted PY - 2007/1/24/pubmed PY - 2007/6/15/medline PY - 2007/1/24/entrez SP - 430 EP - 9 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 17 IS - 6-7 N2 - To examine the efficacy and tolerability of escitalopram in the prevention of relapse in patients with OCD, 468 patients with OCD were treated with open label escitalopram (10 mg or 20 mg) for 16 weeks, after which the 320 responders (Y-BOCS total score decrease > or =25%) were randomised to placebo or escitalopram (at the assigned dose) for 24 weeks double-blind treatment. The primary analysis (time to relapse) showed a significant advantage for escitalopram (p<0.001, log-rank test). The proportion of patients who relapsed was statistically significantly higher in the placebo group (52%) than in the escitalopram group (23%) (p<0.001, chi(2)-test). The risk of relapse was 2.74 times higher for placebo compared to escitalopram. Escitalopram was well tolerated and improvements in obsessive-compulsive symptoms reported during the open label period were sustained during the double-blind extension of treatment with active drug. These results demonstrate that escitalopram is effective for long-term treatment and relapse prevention in OCD. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/17240120/Escitalopram_prevents_relapse_of_obsessive_compulsive_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(06)00255-0 DB - PRIME DP - Unbound Medicine ER -