Tags

Type your tag names separated by a space and hit enter

Memory influences on hippocampal and striatal neural codes: effects of a shift between task rules.
Neurobiol Learn Mem. 2007 May; 87(4):495-509.NL

Abstract

Interactions with neocortical memory systems may facilitate flexible information processing by hippocampus. We sought direct evidence for such memory influences by recording hippocampal neural responses to a change in cognitive strategy. Well-trained rats switched (within a single recording session) between the use of place and response strategies to solve a plus maze task. Maze and extramaze environments were constant throughout testing. Place fields demonstrated (in-field) firing rate and location-based reorganization [Leutgeb, S., Leutgeb, J. K., Barnes, C. A., Moser, E. I., McNaughton, B. L., & Moser, M. B. (2005). Independent codes for spatial and episodic memory in hippocampal neuronal ensembles. Science, 309, 619-623] after a task switch, suggesting that hippocampus encoded each phase of testing as a different context, or episode. The task switch also resulted in qualitative and quantitative changes to discharge that were correlated with an animal's velocity or acceleration of movement. Thus, the effects of a strategy switch extended beyond the spatial domain, and the movement correlates were not passive reflections of the current behavioral state. To determine whether hippocampal neural responses were unique, striatal place and movement-correlated neurons were simultaneously recorded with hippocampal neurons. Striatal place and movement cells exhibited a response profile that was similar, but not identical, to that observed for hippocampus after a strategy switch. Thus, retrieval of a different memory led both neural systems to represent a different context. However, hippocampus may play a special (though not exclusive) role in flexible spatial processing since correlated firing amongst cell pairs was highest when rats successfully switched between two spatial tasks. Correlated firing by striatal cell pairs increased following any strategy switch, supporting the view that striatum codes change in reinforcement contingencies.

Authors+Show Affiliations

Department of Psychology, University of Washington, Seattle, WA 98195, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17240173

Citation

Eschenko, Oxana, and Sheri J Y. Mizumori. "Memory Influences On Hippocampal and Striatal Neural Codes: Effects of a Shift Between Task Rules." Neurobiology of Learning and Memory, vol. 87, no. 4, 2007, pp. 495-509.
Eschenko O, Mizumori SJ. Memory influences on hippocampal and striatal neural codes: effects of a shift between task rules. Neurobiol Learn Mem. 2007;87(4):495-509.
Eschenko, O., & Mizumori, S. J. (2007). Memory influences on hippocampal and striatal neural codes: effects of a shift between task rules. Neurobiology of Learning and Memory, 87(4), 495-509.
Eschenko O, Mizumori SJ. Memory Influences On Hippocampal and Striatal Neural Codes: Effects of a Shift Between Task Rules. Neurobiol Learn Mem. 2007;87(4):495-509. PubMed PMID: 17240173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Memory influences on hippocampal and striatal neural codes: effects of a shift between task rules. AU - Eschenko,Oxana, AU - Mizumori,Sheri J Y, Y1 - 2007/01/19/ PY - 2006/07/27/received PY - 2006/09/20/revised PY - 2006/09/21/accepted PY - 2007/1/24/pubmed PY - 2007/7/17/medline PY - 2007/1/24/entrez SP - 495 EP - 509 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 87 IS - 4 N2 - Interactions with neocortical memory systems may facilitate flexible information processing by hippocampus. We sought direct evidence for such memory influences by recording hippocampal neural responses to a change in cognitive strategy. Well-trained rats switched (within a single recording session) between the use of place and response strategies to solve a plus maze task. Maze and extramaze environments were constant throughout testing. Place fields demonstrated (in-field) firing rate and location-based reorganization [Leutgeb, S., Leutgeb, J. K., Barnes, C. A., Moser, E. I., McNaughton, B. L., & Moser, M. B. (2005). Independent codes for spatial and episodic memory in hippocampal neuronal ensembles. Science, 309, 619-623] after a task switch, suggesting that hippocampus encoded each phase of testing as a different context, or episode. The task switch also resulted in qualitative and quantitative changes to discharge that were correlated with an animal's velocity or acceleration of movement. Thus, the effects of a strategy switch extended beyond the spatial domain, and the movement correlates were not passive reflections of the current behavioral state. To determine whether hippocampal neural responses were unique, striatal place and movement-correlated neurons were simultaneously recorded with hippocampal neurons. Striatal place and movement cells exhibited a response profile that was similar, but not identical, to that observed for hippocampus after a strategy switch. Thus, retrieval of a different memory led both neural systems to represent a different context. However, hippocampus may play a special (though not exclusive) role in flexible spatial processing since correlated firing amongst cell pairs was highest when rats successfully switched between two spatial tasks. Correlated firing by striatal cell pairs increased following any strategy switch, supporting the view that striatum codes change in reinforcement contingencies. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/17240173/Memory_influences_on_hippocampal_and_striatal_neural_codes:_effects_of_a_shift_between_task_rules_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(06)00138-9 DB - PRIME DP - Unbound Medicine ER -