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Clinical efficacy and differential inhibition of menstrual fluid prostaglandin F2alpha in a randomized, double-blind, crossover treatment with placebo, acetaminophen, and ibuprofen in primary dysmenorrhea.
Am J Obstet Gynecol 2007; 196(1):35.e1-5AJ

Abstract

OBJECTIVE

The purpose of this study was to compare acetaminophen with ibuprofen for pain relief and menstrual fluid prostaglandin F2alpha (PGF2alpha) suppression in primary dysmenorrhea.

STUDY DESIGN

Twelve subjects were randomized to placebo, acetaminophen (1000 mg orally, 4 x daily for 3 days) or ibuprofen (400 mg orally, 4 x daily for 3 days), once during each cycle in a prospective, double-blinded, crossover study. Using preweighed super absorbent tampons, menstrual fluid was collected, extracted, and PGF2alpha radioimmunoassayed.

RESULTS

Ten patients completed the study. Ibuprofen (P = .002) and acetaminophen (P = .022) were rated significantly better than placebo. Total menstrual fluid PGF2alpha with placebo was 36.2 + 6.1 microg but were 14.8 + 3.0 microg with ibuprofen (P = .001) and 21.4 + 3.4 microg with acetaminophen (P = .008). PGF2alpha concentrations with placebo were 0.34 + 0.054 microg/mL, with ibuprofen 0.16 + 0.026 microg/mL (P = .001), and with acetaminophen 0.23 + 0.029 microg/mL (P = .016).

CONCLUSION

Both ibuprofen and acetaminophen were superior to placebo for pain relief and menstrual fluid PGF2alpha suppression, with ibuprofen being more potent.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Robert C. Byrd Health Science Center, West Virginia University School of Medicine, Morgantown, WV 26506-9186, USA. ydawood@hsc.wvu.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17240224

Citation

Dawood, M Yusoff, and Firyal S. Khan-Dawood. "Clinical Efficacy and Differential Inhibition of Menstrual Fluid Prostaglandin F2alpha in a Randomized, Double-blind, Crossover Treatment With Placebo, Acetaminophen, and Ibuprofen in Primary Dysmenorrhea." American Journal of Obstetrics and Gynecology, vol. 196, no. 1, 2007, pp. 35.e1-5.
Dawood MY, Khan-Dawood FS. Clinical efficacy and differential inhibition of menstrual fluid prostaglandin F2alpha in a randomized, double-blind, crossover treatment with placebo, acetaminophen, and ibuprofen in primary dysmenorrhea. Am J Obstet Gynecol. 2007;196(1):35.e1-5.
Dawood, M. Y., & Khan-Dawood, F. S. (2007). Clinical efficacy and differential inhibition of menstrual fluid prostaglandin F2alpha in a randomized, double-blind, crossover treatment with placebo, acetaminophen, and ibuprofen in primary dysmenorrhea. American Journal of Obstetrics and Gynecology, 196(1), pp. 35.e1-5.
Dawood MY, Khan-Dawood FS. Clinical Efficacy and Differential Inhibition of Menstrual Fluid Prostaglandin F2alpha in a Randomized, Double-blind, Crossover Treatment With Placebo, Acetaminophen, and Ibuprofen in Primary Dysmenorrhea. Am J Obstet Gynecol. 2007;196(1):35.e1-5. PubMed PMID: 17240224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical efficacy and differential inhibition of menstrual fluid prostaglandin F2alpha in a randomized, double-blind, crossover treatment with placebo, acetaminophen, and ibuprofen in primary dysmenorrhea. AU - Dawood,M Yusoff, AU - Khan-Dawood,Firyal S, PY - 2006/02/20/received PY - 2006/06/13/revised PY - 2006/06/29/accepted PY - 2007/1/24/pubmed PY - 2007/3/9/medline PY - 2007/1/24/entrez SP - 35.e1 EP - 5 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 196 IS - 1 N2 - OBJECTIVE: The purpose of this study was to compare acetaminophen with ibuprofen for pain relief and menstrual fluid prostaglandin F2alpha (PGF2alpha) suppression in primary dysmenorrhea. STUDY DESIGN: Twelve subjects were randomized to placebo, acetaminophen (1000 mg orally, 4 x daily for 3 days) or ibuprofen (400 mg orally, 4 x daily for 3 days), once during each cycle in a prospective, double-blinded, crossover study. Using preweighed super absorbent tampons, menstrual fluid was collected, extracted, and PGF2alpha radioimmunoassayed. RESULTS: Ten patients completed the study. Ibuprofen (P = .002) and acetaminophen (P = .022) were rated significantly better than placebo. Total menstrual fluid PGF2alpha with placebo was 36.2 + 6.1 microg but were 14.8 + 3.0 microg with ibuprofen (P = .001) and 21.4 + 3.4 microg with acetaminophen (P = .008). PGF2alpha concentrations with placebo were 0.34 + 0.054 microg/mL, with ibuprofen 0.16 + 0.026 microg/mL (P = .001), and with acetaminophen 0.23 + 0.029 microg/mL (P = .016). CONCLUSION: Both ibuprofen and acetaminophen were superior to placebo for pain relief and menstrual fluid PGF2alpha suppression, with ibuprofen being more potent. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/17240224/Clinical_efficacy_and_differential_inhibition_of_menstrual_fluid_prostaglandin_F2alpha_in_a_randomized_double_blind_crossover_treatment_with_placebo_acetaminophen_and_ibuprofen_in_primary_dysmenorrhea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(06)01152-5 DB - PRIME DP - Unbound Medicine ER -