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Methionine and vitamin B6 intake and risk of pancreatic cancer: a prospective study of Swedish women and men.
Gastroenterology. 2007 Jan; 132(1):113-8.G

Abstract

BACKGROUND & AIMS

It has been hypothesized that dietary factors involved in methyl group metabolism, such as methionine, folate, and vitamin B(6), may modify cancer risk. We have previously reported an inverse association between folate intake and pancreatic cancer risk in a prospective population-based cohort of Swedish women and men. In the present study, we used data from this prospective study to examine whether methionine and vitamin B(6) intakes were associated with the incidence of exocrine pancreatic cancer.

METHODS

Our study population comprised 81,922 Swedish women and men, aged 45-83 years, who were free from cancer and completed a self-administered food-frequency questionnaire in 1997. We used Cox proportional hazards models to estimate rate ratios with 95% confidence intervals (CI), adjusted for age, sex, education, smoking, body mass index, diabetes, and intakes of total energy and dietary folate.

RESULTS

During a mean follow-up of 7.2 years, through June 2005, 147 incident cases of pancreatic cancer were diagnosed. Methionine intake was significantly inversely associated with risk of pancreatic cancer, whereas no significant association was observed for dietary or total vitamin B(6) intake. The multivariate rate ratios comparing the highest with the lowest quartile of methionine intake were 0.44 (95% CI, 0.26-0.73; P for trend = .0005) in women and men combined, 0.59 (95% CI, 0.28-1.21; P for trend = .07) in women, and 0.32 (95% CI, 0.15-0.65; P for trend = .002) in men.

CONCLUSIONS

These findings suggest that higher methionine intake may reduce the risk of pancreatic cancer.

Links

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Authors+Show Affiliations

Larsson SC
Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden. susanna.larson@ki.se
Giovannucci E
No affiliation info available
Wolk A
No affiliation info available

MeSH

AgedAged, 80 and overDietary SupplementsFemaleFollow-Up StudiesHumansIncidenceMaleMethionineMiddle AgedPancreas, ExocrinePancreatic NeoplasmsProspective StudiesRisk FactorsSurveys and QuestionnairesSwedenVitamin B 6Vitamin B Complex

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17241865

Citation

Larsson, Susanna C., et al. "Methionine and Vitamin B6 Intake and Risk of Pancreatic Cancer: a Prospective Study of Swedish Women and Men." Gastroenterology, vol. 132, no. 1, 2007, pp. 113-8.
Larsson SC, Giovannucci E, Wolk A. Methionine and vitamin B6 intake and risk of pancreatic cancer: a prospective study of Swedish women and men. Gastroenterology. 2007;132(1):113-8.
Larsson, S. C., Giovannucci, E., & Wolk, A. (2007). Methionine and vitamin B6 intake and risk of pancreatic cancer: a prospective study of Swedish women and men. Gastroenterology, 132(1), 113-8.
Larsson SC, Giovannucci E, Wolk A. Methionine and Vitamin B6 Intake and Risk of Pancreatic Cancer: a Prospective Study of Swedish Women and Men. Gastroenterology. 2007;132(1):113-8. PubMed PMID: 17241865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methionine and vitamin B6 intake and risk of pancreatic cancer: a prospective study of Swedish women and men. AU - Larsson,Susanna C, AU - Giovannucci,Edward, AU - Wolk,Alicja, Y1 - 2006/10/12/ PY - 2006/08/06/received PY - 2006/09/21/accepted PY - 2007/1/24/pubmed PY - 2007/3/16/medline PY - 2007/1/24/entrez SP - 113 EP - 8 JF - Gastroenterology JO - Gastroenterology VL - 132 IS - 1 N2 - BACKGROUND & AIMS: It has been hypothesized that dietary factors involved in methyl group metabolism, such as methionine, folate, and vitamin B(6), may modify cancer risk. We have previously reported an inverse association between folate intake and pancreatic cancer risk in a prospective population-based cohort of Swedish women and men. In the present study, we used data from this prospective study to examine whether methionine and vitamin B(6) intakes were associated with the incidence of exocrine pancreatic cancer. METHODS: Our study population comprised 81,922 Swedish women and men, aged 45-83 years, who were free from cancer and completed a self-administered food-frequency questionnaire in 1997. We used Cox proportional hazards models to estimate rate ratios with 95% confidence intervals (CI), adjusted for age, sex, education, smoking, body mass index, diabetes, and intakes of total energy and dietary folate. RESULTS: During a mean follow-up of 7.2 years, through June 2005, 147 incident cases of pancreatic cancer were diagnosed. Methionine intake was significantly inversely associated with risk of pancreatic cancer, whereas no significant association was observed for dietary or total vitamin B(6) intake. The multivariate rate ratios comparing the highest with the lowest quartile of methionine intake were 0.44 (95% CI, 0.26-0.73; P for trend = .0005) in women and men combined, 0.59 (95% CI, 0.28-1.21; P for trend = .07) in women, and 0.32 (95% CI, 0.15-0.65; P for trend = .002) in men. CONCLUSIONS: These findings suggest that higher methionine intake may reduce the risk of pancreatic cancer. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/17241865/Methionine_and_vitamin_B6_intake_and_risk_of_pancreatic_cancer:_a_prospective_study_of_Swedish_women_and_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(06)02240-2 DB - PRIME DP - Unbound Medicine ER -