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Parkinson's disease and pesticide exposures.
Br Med Bull. 2006; 79-80:219-31.BM

Abstract

INTRODUCTION

Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder in which loss of dopaminergic neurons in the basal ganglia leads to tremor, bradykinesia, rigidity and postural instability.

METHODS

Literature search using Medline with keywords 'Parkinson's disease' and 'pesticides', limited to English, was undertaken, supplemented by articles from the author's files.

RESULTS

Many studies have found an association between pesticides and PD, but no one agent has been consistently identified. Those implicated include organochlorine insecticides, maneb and paraquat. One meta-analysis of pesticide exposure and PD found an almost doubling of risk in those exposed. Associations with specific agents may be confounded by exposure to other pesticides, making it difficult to identify the causative agent.

CONCLUSIONS

The available evidence indicates that pesticides are associated with PD, but further research is needed to identify long-term biomarkers of exposure, improve methods for estimating pesticide-exposure and undertake prospective cohort studies of pesticide-exposed workers.

Authors+Show Affiliations

Department of Environmental and Occupational Medicine, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, Aberdeenshire, UK. f.dick@abdn.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17242039

Citation

Dick, Finlay D.. "Parkinson's Disease and Pesticide Exposures." British Medical Bulletin, vol. 79-80, 2006, pp. 219-31.
Dick FD. Parkinson's disease and pesticide exposures. Br Med Bull. 2006;79-80:219-31.
Dick, F. D. (2006). Parkinson's disease and pesticide exposures. British Medical Bulletin, 79-80, 219-31.
Dick FD. Parkinson's Disease and Pesticide Exposures. Br Med Bull. 2006;79-80:219-31. PubMed PMID: 17242039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease and pesticide exposures. A1 - Dick,Finlay D, Y1 - 2007/01/22/ PY - 2007/1/24/pubmed PY - 2007/7/28/medline PY - 2007/1/24/entrez SP - 219 EP - 31 JF - British medical bulletin JO - Br Med Bull VL - 79-80 N2 - INTRODUCTION: Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder in which loss of dopaminergic neurons in the basal ganglia leads to tremor, bradykinesia, rigidity and postural instability. METHODS: Literature search using Medline with keywords 'Parkinson's disease' and 'pesticides', limited to English, was undertaken, supplemented by articles from the author's files. RESULTS: Many studies have found an association between pesticides and PD, but no one agent has been consistently identified. Those implicated include organochlorine insecticides, maneb and paraquat. One meta-analysis of pesticide exposure and PD found an almost doubling of risk in those exposed. Associations with specific agents may be confounded by exposure to other pesticides, making it difficult to identify the causative agent. CONCLUSIONS: The available evidence indicates that pesticides are associated with PD, but further research is needed to identify long-term biomarkers of exposure, improve methods for estimating pesticide-exposure and undertake prospective cohort studies of pesticide-exposed workers. SN - 0007-1420 UR - https://www.unboundmedicine.com/medline/citation/17242039/Parkinson's_disease_and_pesticide_exposures_ L2 - https://academic.oup.com/bmb/article-lookup/doi/10.1093/bmb/ldl018 DB - PRIME DP - Unbound Medicine ER -