TY - JOUR T1 - Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. AU - Allakhverdi,Zoulfia, AU - Comeau,Michael R, AU - Jessup,Heidi K, AU - Yoon,Bo-Rin Park, AU - Brewer,Avery, AU - Chartier,Suzanne, AU - Paquette,Nicole, AU - Ziegler,Steven F, AU - Sarfati,Marika, AU - Delespesse,Guy, Y1 - 2007/01/22/ PY - 2007/1/24/pubmed PY - 2007/3/27/medline PY - 2007/1/24/entrez SP - 253 EP - 8 JF - The Journal of experimental medicine JO - J Exp Med VL - 204 IS - 2 N2 - Compelling evidence suggests that the epithelial cell-derived cytokine thymic stromal lymphopoietin (TSLP) may initiate asthma or atopic dermatitis through a dendritic cell-mediated T helper (Th)2 response. Here, we describe how TSLP might initiate and aggravate allergic inflammation in the absence of T lymphocytes and immunoglobulin E antibodies via the innate immune system. We show that TSLP, synergistically with interleukin 1 and tumor necrosis factor, stimulates the production of high levels of Th2 cytokines by human mast cells (MCs). We next report that TSLP is released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines. Direct epithelial cell-mediated, TSLP-dependent activation of MCs may play a central role in "intrinsic" forms of atopic diseases and explain the aggravating role of infection and scratching in these diseases. SN - 0022-1007 UR - https://www.unboundmedicine.com/medline/citation/17242164/Thymic_stromal_lymphopoietin_is_released_by_human_epithelial_cells_in_response_to_microbes_trauma_or_inflammation_and_potently_activates_mast_cells_ L2 - https://rupress.org/jem/article-lookup/doi/10.1084/jem.20062211 DB - PRIME DP - Unbound Medicine ER -