Citation
Allakhverdi, Zoulfia, et al. "Thymic Stromal Lymphopoietin Is Released By Human Epithelial Cells in Response to Microbes, Trauma, or Inflammation and Potently Activates Mast Cells." The Journal of Experimental Medicine, vol. 204, no. 2, 2007, pp. 253-8.
Allakhverdi Z, Comeau MR, Jessup HK, et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med. 2007;204(2):253-8.
Allakhverdi, Z., Comeau, M. R., Jessup, H. K., Yoon, B. R., Brewer, A., Chartier, S., Paquette, N., Ziegler, S. F., Sarfati, M., & Delespesse, G. (2007). Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. The Journal of Experimental Medicine, 204(2), 253-8.
Allakhverdi Z, et al. Thymic Stromal Lymphopoietin Is Released By Human Epithelial Cells in Response to Microbes, Trauma, or Inflammation and Potently Activates Mast Cells. J Exp Med. 2007 Feb 19;204(2):253-8. PubMed PMID: 17242164.
TY - JOUR
T1 - Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells.
AU - Allakhverdi,Zoulfia,
AU - Comeau,Michael R,
AU - Jessup,Heidi K,
AU - Yoon,Bo-Rin Park,
AU - Brewer,Avery,
AU - Chartier,Suzanne,
AU - Paquette,Nicole,
AU - Ziegler,Steven F,
AU - Sarfati,Marika,
AU - Delespesse,Guy,
Y1 - 2007/01/22/
PY - 2007/1/24/pubmed
PY - 2007/3/27/medline
PY - 2007/1/24/entrez
SP - 253
EP - 8
JF - The Journal of experimental medicine
JO - J Exp Med
VL - 204
IS - 2
N2 - Compelling evidence suggests that the epithelial cell-derived cytokine thymic stromal lymphopoietin (TSLP) may initiate asthma or atopic dermatitis through a dendritic cell-mediated T helper (Th)2 response. Here, we describe how TSLP might initiate and aggravate allergic inflammation in the absence of T lymphocytes and immunoglobulin E antibodies via the innate immune system. We show that TSLP, synergistically with interleukin 1 and tumor necrosis factor, stimulates the production of high levels of Th2 cytokines by human mast cells (MCs). We next report that TSLP is released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines. Direct epithelial cell-mediated, TSLP-dependent activation of MCs may play a central role in "intrinsic" forms of atopic diseases and explain the aggravating role of infection and scratching in these diseases.
SN - 0022-1007
UR - https://www.unboundmedicine.com/medline/citation/17242164/Thymic_stromal_lymphopoietin_is_released_by_human_epithelial_cells_in_response_to_microbes_trauma_or_inflammation_and_potently_activates_mast_cells_
L2 - https://rupress.org/jem/article-lookup/doi/10.1084/jem.20062211
DB - PRIME
DP - Unbound Medicine
ER -