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Conversion from subtypes of mild cognitive impairment to Alzheimer dementia.
Neurology. 2007 Jan 23; 68(4):288-91.Neur

Abstract

OBJECTIVE

To compare the rates of conversion to Alzheimer dementia (AD) between subtypes of mild cognitive impairment (MCI) in a community-based birth cohort investigated at age 75 and followed up after 30 months.

METHODS

The Vienna Trans-Danube Aging Study investigated every inhabitant of the area on the left shore of the river Danube who was born between May 1925 and June 1926. With use of the official voting registry, 1505 subjects were contacted and 697 participated. Data refer to the cohort of 581 nondemented individuals who completed extensive neuropsychological examination at baseline. Follow-up after 30 months was possible in 476 probands (35 deceased).

RESULTS

The 141 patients with MCI at baseline were classified into two subtypes. At follow-up, 41 of these patients with MCI were diagnosed with AD. Conversion rates to AD were 48.7% (CI: 32.4 to 65.2) for amnestic MCI and 26.8% (CI: 17.6 to 37.8) for nonamnestic MCI. Another 49 AD cases originated from cognitive health at baseline (12.6%; CI: 9.4 to 16.3).

CONCLUSIONS

Patients with mild cognitive impairment (MCI) showed a high probability to be diagnosed with Alzheimer dementia (AD) after 30 months. Subtypes of MCI were not useful in defining early stages of various types of dementia: Not only amnestic MCI but also nonamnestic MCI converted frequently to AD, and conversion to vascular dementia and dementia with Lewy bodies was not restricted to nonamnestic MCI.

Authors+Show Affiliations

Ludwig Boltzmann Institute of Aging Research, Medical University Vienna, Vienna, Austria. Peter.Fischer@meduniwien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17242334

Citation

Fischer, P, et al. "Conversion From Subtypes of Mild Cognitive Impairment to Alzheimer Dementia." Neurology, vol. 68, no. 4, 2007, pp. 288-91.
Fischer P, Jungwirth S, Zehetmayer S, et al. Conversion from subtypes of mild cognitive impairment to Alzheimer dementia. Neurology. 2007;68(4):288-91.
Fischer, P., Jungwirth, S., Zehetmayer, S., Weissgram, S., Hoenigschnabl, S., Gelpi, E., Krampla, W., & Tragl, K. H. (2007). Conversion from subtypes of mild cognitive impairment to Alzheimer dementia. Neurology, 68(4), 288-91.
Fischer P, et al. Conversion From Subtypes of Mild Cognitive Impairment to Alzheimer Dementia. Neurology. 2007 Jan 23;68(4):288-91. PubMed PMID: 17242334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conversion from subtypes of mild cognitive impairment to Alzheimer dementia. AU - Fischer,P, AU - Jungwirth,S, AU - Zehetmayer,S, AU - Weissgram,S, AU - Hoenigschnabl,S, AU - Gelpi,E, AU - Krampla,W, AU - Tragl,K H, PY - 2007/1/24/pubmed PY - 2007/2/22/medline PY - 2007/1/24/entrez SP - 288 EP - 91 JF - Neurology JO - Neurology VL - 68 IS - 4 N2 - OBJECTIVE: To compare the rates of conversion to Alzheimer dementia (AD) between subtypes of mild cognitive impairment (MCI) in a community-based birth cohort investigated at age 75 and followed up after 30 months. METHODS: The Vienna Trans-Danube Aging Study investigated every inhabitant of the area on the left shore of the river Danube who was born between May 1925 and June 1926. With use of the official voting registry, 1505 subjects were contacted and 697 participated. Data refer to the cohort of 581 nondemented individuals who completed extensive neuropsychological examination at baseline. Follow-up after 30 months was possible in 476 probands (35 deceased). RESULTS: The 141 patients with MCI at baseline were classified into two subtypes. At follow-up, 41 of these patients with MCI were diagnosed with AD. Conversion rates to AD were 48.7% (CI: 32.4 to 65.2) for amnestic MCI and 26.8% (CI: 17.6 to 37.8) for nonamnestic MCI. Another 49 AD cases originated from cognitive health at baseline (12.6%; CI: 9.4 to 16.3). CONCLUSIONS: Patients with mild cognitive impairment (MCI) showed a high probability to be diagnosed with Alzheimer dementia (AD) after 30 months. Subtypes of MCI were not useful in defining early stages of various types of dementia: Not only amnestic MCI but also nonamnestic MCI converted frequently to AD, and conversion to vascular dementia and dementia with Lewy bodies was not restricted to nonamnestic MCI. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17242334/Conversion_from_subtypes_of_mild_cognitive_impairment_to_Alzheimer_dementia_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=17242334 DB - PRIME DP - Unbound Medicine ER -