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Longitudinal evaluation of serum leptin and bone mineral density in early postmenopausal women.
Menopause. 2007 May-Jun; 14(3 Pt 1):450-4.M

Abstract

OBJECTIVE

To evaluate total and site-specific bone mineral density (BMD) and serum leptin levels in postmenopausal women treated with a calcium supplement and in postmenopausal women receiving estrogen plus progestin therapy.

DESIGN

Forty-four women were randomized to receive either calcium supplementation (group A, n = 22) or transdermal 17beta-estradiol at a dose of 50 mug/day in a continuous regimen and nomegestrol at a dose of 5 mg/day for 12 days per month in a sequential regimen (group B, n = 22). All women underwent dual-energy x-ray absorptiometry determination of BMD and blood sampling in the morning at the beginning of the study and after 12 months. Leptin was determined by radioimmunoassay in all samples.

RESULTS

After 12 months, serum leptin levels were significantly higher in group A (control) in comparison with group B and baseline values, whereas both total and pelvic BMDs were significantly lower in group A in comparison with group B and baseline values. At baseline, a significant correlation was found between leptin levels, body mass index, and total-body BMD. After 12 months, leptin was still correlated to body mass index in both groups, but the association with BMD was lost.

CONCLUSIONS

This study confirms previous evidence of a significant correlation between serum leptin and BMD in early postmenopausal women. Furthermore, this correlation is lost over time during the progression of the postmenopausal period, independently from the administration of estrogen-progestin therapy. Further studies and longer follow-up periods are needed to better understand theses issues.

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Authors+Show Affiliations

Di Carlo C
Department of Gynecology and Obstetrics, University of Naples Federico II, Italy. costantino.dicarlo@unina.it
Tommaselli GA
No affiliation info available
Di Spiezio Sardo A
No affiliation info available
Sammartino A
No affiliation info available
Attianese W
No affiliation info available
Gargano V
No affiliation info available
Bifulco G
No affiliation info available
Nappi C
No affiliation info available

MeSH

Absorptiometry, PhotonBone DensityBone Density Conservation AgentsCalcium, DietaryDose-Response Relationship, DrugEstradiolEstrogen Replacement TherapyFemaleFollow-Up StudiesHumansLeptinMegestrolMiddle AgedPostmenopauseTreatment Outcome

Pub Type(s)

Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17242633

Citation

Di Carlo, Costantino, et al. "Longitudinal Evaluation of Serum Leptin and Bone Mineral Density in Early Postmenopausal Women." Menopause (New York, N.Y.), vol. 14, no. 3 Pt 1, 2007, pp. 450-4.
Di Carlo C, Tommaselli GA, Di Spiezio Sardo A, et al. Longitudinal evaluation of serum leptin and bone mineral density in early postmenopausal women. Menopause. 2007;14(3 Pt 1):450-4.
Di Carlo, C., Tommaselli, G. A., Di Spiezio Sardo, A., Sammartino, A., Attianese, W., Gargano, V., Bifulco, G., & Nappi, C. (2007). Longitudinal evaluation of serum leptin and bone mineral density in early postmenopausal women. Menopause (New York, N.Y.), 14(3 Pt 1), 450-4.
Di Carlo C, et al. Longitudinal Evaluation of Serum Leptin and Bone Mineral Density in Early Postmenopausal Women. Menopause. 2007 May-Jun;14(3 Pt 1):450-4. PubMed PMID: 17242633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal evaluation of serum leptin and bone mineral density in early postmenopausal women. AU - Di Carlo,Costantino, AU - Tommaselli,Giovanni A, AU - Di Spiezio Sardo,Attilio, AU - Sammartino,Annalidia, AU - Attianese,Wanda, AU - Gargano,Virginia, AU - Bifulco,Giuseppe, AU - Nappi,Carmine, PY - 2007/1/24/pubmed PY - 2007/7/13/medline PY - 2007/1/24/entrez SP - 450 EP - 4 JF - Menopause (New York, N.Y.) JO - Menopause VL - 14 IS - 3 Pt 1 N2 - OBJECTIVE: To evaluate total and site-specific bone mineral density (BMD) and serum leptin levels in postmenopausal women treated with a calcium supplement and in postmenopausal women receiving estrogen plus progestin therapy. DESIGN: Forty-four women were randomized to receive either calcium supplementation (group A, n = 22) or transdermal 17beta-estradiol at a dose of 50 mug/day in a continuous regimen and nomegestrol at a dose of 5 mg/day for 12 days per month in a sequential regimen (group B, n = 22). All women underwent dual-energy x-ray absorptiometry determination of BMD and blood sampling in the morning at the beginning of the study and after 12 months. Leptin was determined by radioimmunoassay in all samples. RESULTS: After 12 months, serum leptin levels were significantly higher in group A (control) in comparison with group B and baseline values, whereas both total and pelvic BMDs were significantly lower in group A in comparison with group B and baseline values. At baseline, a significant correlation was found between leptin levels, body mass index, and total-body BMD. After 12 months, leptin was still correlated to body mass index in both groups, but the association with BMD was lost. CONCLUSIONS: This study confirms previous evidence of a significant correlation between serum leptin and BMD in early postmenopausal women. Furthermore, this correlation is lost over time during the progression of the postmenopausal period, independently from the administration of estrogen-progestin therapy. Further studies and longer follow-up periods are needed to better understand theses issues. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/17242633/Longitudinal_evaluation_of_serum_leptin_and_bone_mineral_density_in_early_postmenopausal_women_ L2 - https://doi.org/10.1097/01.gme.0000236936.28454.6a DB - PRIME DP - Unbound Medicine ER -
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