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Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria.
Bull World Health Organ. 2006 Dec; 84(12):956-64.BW

Abstract

OBJECTIVE

To test a novel methodology to define age-based dosing regimens for the treatment of malaria with a new, user-friendly, blister-packaged fixed-dose combination of artesunate and amodiaquine.

METHODS

A weight-for-age reference database of 88 054 individuals from sub-Saharan Africa was compiled using data from Demographic Health Surveys, observational and intervention studies, and standardized for sex, age and malaria risk. We then determined the optimal tablet strength (milligram (mg) per tablet) and age-dose categories for the combination of artesunate and amodiaquine. The proportions of patients predicted to receive doses within newly defined therapeutic ranges for amodiaquine (7-15 mg/kg/day) and artesunate (2-10 mg/kg/day), were estimated for different age categories and mg tablet strengths using models based on the weight-for-age reference database.

FINDINGS

The optimal paediatric (p) and adult (a) strength tablets contained 25/67.5 and 100/270 mg artesunate/amodiaquine, respectively. A regimen with five age categories: 0-1 months (1/2 p), 2-11 months (1 p), 1-5 years (2 p), 6-13 years (1 a), and > 14 years (2 a) had an overall dosing accuracy of 83.4% and 99.9% for amodiaquine and artesunate, respectively.

CONCLUSION

The proposed method to use weight-for-age reference data from countries where malaria is endemic is a useful tool for designing age-based dosing regimens for antimalarial drugs for drug registration and field use.

Authors+Show Affiliations

Special Programme for Research and Training in Tropical Diseases, United Nations Children's Fund/World Bank/United Nations Development Programme/World Health Organization, Geneva, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17242831

Citation

Taylor, Walter R J., et al. "Use of Weight-for-age-data to Optimize Tablet Strength and Dosing Regimens for a New Fixed-dose Artesunate-amodiaquine Combination for Treating Falciparum Malaria." Bulletin of the World Health Organization, vol. 84, no. 12, 2006, pp. 956-64.
Taylor W, Terlouw DJ, Olliaro PL, et al. Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria. Bull World Health Organ. 2006;84(12):956-64.
Taylor, W., Terlouw, D. J., Olliaro, P. L., White, N. J., Brasseur, P., & ter Kuile, F. O. (2006). Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria. Bulletin of the World Health Organization, 84(12), 956-64.
Taylor W, et al. Use of Weight-for-age-data to Optimize Tablet Strength and Dosing Regimens for a New Fixed-dose Artesunate-amodiaquine Combination for Treating Falciparum Malaria. Bull World Health Organ. 2006;84(12):956-64. PubMed PMID: 17242831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria. AU - Taylor,Walter R J, AU - Terlouw,Dianne J, AU - Olliaro,Piero L, AU - White,Nicholas J, AU - Brasseur,Philippe, AU - ter Kuile,Feiko O, PY - 2006/03/10/received PY - 2006/05/24/accepted PY - 2007/1/24/pubmed PY - 2007/2/17/medline PY - 2007/1/24/entrez SP - 956 EP - 64 JF - Bulletin of the World Health Organization JO - Bull World Health Organ VL - 84 IS - 12 N2 - OBJECTIVE: To test a novel methodology to define age-based dosing regimens for the treatment of malaria with a new, user-friendly, blister-packaged fixed-dose combination of artesunate and amodiaquine. METHODS: A weight-for-age reference database of 88 054 individuals from sub-Saharan Africa was compiled using data from Demographic Health Surveys, observational and intervention studies, and standardized for sex, age and malaria risk. We then determined the optimal tablet strength (milligram (mg) per tablet) and age-dose categories for the combination of artesunate and amodiaquine. The proportions of patients predicted to receive doses within newly defined therapeutic ranges for amodiaquine (7-15 mg/kg/day) and artesunate (2-10 mg/kg/day), were estimated for different age categories and mg tablet strengths using models based on the weight-for-age reference database. FINDINGS: The optimal paediatric (p) and adult (a) strength tablets contained 25/67.5 and 100/270 mg artesunate/amodiaquine, respectively. A regimen with five age categories: 0-1 months (1/2 p), 2-11 months (1 p), 1-5 years (2 p), 6-13 years (1 a), and > 14 years (2 a) had an overall dosing accuracy of 83.4% and 99.9% for amodiaquine and artesunate, respectively. CONCLUSION: The proposed method to use weight-for-age reference data from countries where malaria is endemic is a useful tool for designing age-based dosing regimens for antimalarial drugs for drug registration and field use. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/17242831/Use_of_weight_for_age_data_to_optimize_tablet_strength_and_dosing_regimens_for_a_new_fixed_dose_artesunate_amodiaquine_combination_for_treating_falciparum_malaria_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/17242831/ DB - PRIME DP - Unbound Medicine ER -