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Airflow limitation among workers in a labour-intensive coal mine in Tanzania.
Int Arch Occup Environ Health. 2007 Jul; 80(7):567-75.IA

Abstract

OBJECTIVES

To describe the relationship between cumulative respirable dust and quartz exposure and lung functioning among workers in a labour-intensive coal mine.

METHODS

The study population comprised 299 men working at a coal mine in Tanzania. Lung function was assessed using a Vitalograph alpha III spirometer in accordance with American Thoracic Society recommendations. Multiple linear regression models were developed to study the relationship between forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC and the cumulative dust or quartz exposure while adjusting for age, height and ever smoking. To evaluate trends for dose response, cumulative exposure concentrations for respirable dust and quartz were ranked and categorized in quartiles and the highest decile, with the first quartile as the reference group. Logistic regression models were used to determine odds ratios for FEV(1)/FVC < 0.7 and FEV(1)% < 80 for categories of cumulative dust or quartz exposure.

RESULTS

The prevalence of FEV(1)/FVC < 0.7 among the workers was 17.3%. Workers in the development team (20.5%) had the highest prevalence of FEV(1)% < 80%. The estimates of the effects of cumulative exposure on FEV(1)/FVC were -0.015% per mg years m(-3) for respirable dust and -0.3% per mg years m(-3) for respirable quartz. In logistic regression models, the odds ratios for airway limitation (FEV(1)/FVC < 0.7) for the workers in the highest decile of cumulative dust and quartz exposure versus the referents were 4.36 (95% confidence interval: 1.06, 17.96) and 3.49 (0.92, 13.21), respectively. The upper 10% of workers by cumulative dust and quartz exposure also had higher odds ratios for predicted FEV(1)% < 80% than the reference group odds ratio: 10.38 (1.38, 78.13) and 14.18 (1.72, 116.59), respectively. The results must be interpreted with caution due to a possible healthy worker effect and selection bias.

CONCLUSION

Exposure to respirable coal mine dust was associated with airway limitation as measured by FEV(1)/FVC and predicted FEV(1)%.

Authors+Show Affiliations

Centre for International Health and Section for Occupational Medicine, Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, 5018, Bergen, Norway. mamuyasimon@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17242954

Citation

Mamuya, Simon H D., et al. "Airflow Limitation Among Workers in a Labour-intensive Coal Mine in Tanzania." International Archives of Occupational and Environmental Health, vol. 80, no. 7, 2007, pp. 567-75.
Mamuya SH, Bråtveit M, Mashalla YJ, et al. Airflow limitation among workers in a labour-intensive coal mine in Tanzania. Int Arch Occup Environ Health. 2007;80(7):567-75.
Mamuya, S. H., Bråtveit, M., Mashalla, Y. J., & Moen, B. E. (2007). Airflow limitation among workers in a labour-intensive coal mine in Tanzania. International Archives of Occupational and Environmental Health, 80(7), 567-75.
Mamuya SH, et al. Airflow Limitation Among Workers in a Labour-intensive Coal Mine in Tanzania. Int Arch Occup Environ Health. 2007;80(7):567-75. PubMed PMID: 17242954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airflow limitation among workers in a labour-intensive coal mine in Tanzania. AU - Mamuya,Simon H D, AU - Bråtveit,Magne, AU - Mashalla,Yohana J S, AU - Moen,Bente E, Y1 - 2007/01/23/ PY - 2006/04/19/received PY - 2006/11/17/accepted PY - 2007/1/24/pubmed PY - 2007/10/10/medline PY - 2007/1/24/entrez SP - 567 EP - 75 JF - International archives of occupational and environmental health JO - Int Arch Occup Environ Health VL - 80 IS - 7 N2 - OBJECTIVES: To describe the relationship between cumulative respirable dust and quartz exposure and lung functioning among workers in a labour-intensive coal mine. METHODS: The study population comprised 299 men working at a coal mine in Tanzania. Lung function was assessed using a Vitalograph alpha III spirometer in accordance with American Thoracic Society recommendations. Multiple linear regression models were developed to study the relationship between forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC and the cumulative dust or quartz exposure while adjusting for age, height and ever smoking. To evaluate trends for dose response, cumulative exposure concentrations for respirable dust and quartz were ranked and categorized in quartiles and the highest decile, with the first quartile as the reference group. Logistic regression models were used to determine odds ratios for FEV(1)/FVC < 0.7 and FEV(1)% < 80 for categories of cumulative dust or quartz exposure. RESULTS: The prevalence of FEV(1)/FVC < 0.7 among the workers was 17.3%. Workers in the development team (20.5%) had the highest prevalence of FEV(1)% < 80%. The estimates of the effects of cumulative exposure on FEV(1)/FVC were -0.015% per mg years m(-3) for respirable dust and -0.3% per mg years m(-3) for respirable quartz. In logistic regression models, the odds ratios for airway limitation (FEV(1)/FVC < 0.7) for the workers in the highest decile of cumulative dust and quartz exposure versus the referents were 4.36 (95% confidence interval: 1.06, 17.96) and 3.49 (0.92, 13.21), respectively. The upper 10% of workers by cumulative dust and quartz exposure also had higher odds ratios for predicted FEV(1)% < 80% than the reference group odds ratio: 10.38 (1.38, 78.13) and 14.18 (1.72, 116.59), respectively. The results must be interpreted with caution due to a possible healthy worker effect and selection bias. CONCLUSION: Exposure to respirable coal mine dust was associated with airway limitation as measured by FEV(1)/FVC and predicted FEV(1)%. SN - 0340-0131 UR - https://www.unboundmedicine.com/medline/citation/17242954/Airflow_limitation_among_workers_in_a_labour_intensive_coal_mine_in_Tanzania_ L2 - https://dx.doi.org/10.1007/s00420-006-0167-7 DB - PRIME DP - Unbound Medicine ER -