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Carotenoid absorption in humans consuming tomato sauces obtained from tangerine or high-beta-carotene varieties of tomatoes.

Abstract

Tomato sauces were produced from unique tomato varieties to study carotenoid absorption in humans. Tangerine tomatoes, high in cis-lycopene, especially prolycopene (7Z,9Z,7'Z,9'Z), and high-beta-carotene tomatoes as an alternative dietary source of beta-carotene were grown and processed. Sauces were served after 2 week washout periods and overnight fasting for breakfast to healthy subjects (n = 12, 6M/6F) in a randomized crossover design. The serving size was 150 g (containing 15 g of corn oil), tangerine sauce containing 13 mg of lycopene (97.0% as cis-isomers) and high-beta-carotene sauce containing 17 mg of total beta-carotene (1.6% as the 9-cis-isomer) and 4 mg of lycopene. Blood samples were collected 0, 2, 3, 4, 5, 6, 8, and 9.5 h following test meal consumption and carotenoids determined in the plasma triacylglycerol-rich lipoprotein fraction by HPLC-electrochemical detection. Baseline-corrected areas under the concentration vs time curves (AUC) were used as a measure of absorption. AUC0-9.5h values for total lycopene in the tangerine sauce group were 870 +/- 187 (nmol.h)/L (mean +/- SEM) with >99% as cis-isomers (59% as the tetra-cis-isomer). The AUC0-9.5h values for total beta-carotene and lycopene after consumption of the high-beta-carotene sauce were 304 +/- 54 (4% as 9-cis-carotene) and 118 +/- 24 (nmol.h)/L, respectively. Lycopene dose-adjusted triacylglycerol-rich lipoprotein AUC responses in the tangerine sauce group were relatively high when compared to those in the literature and the high-beta-carotene group. The results support the hypothesis that lycopene cis-isomers are highly bioavailable and suggest that special tomato varieties can be utilized to increase both the intake and bioavailability of health-beneficial carotenoids.

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  • Authors+Show Affiliations

    ,

    Department of Food Science and Technology, 2015 Fyffe Road, The Ohio State University, 320 West 10th Avenue, Columbus, OH 43210, USA.

    , , ,

    Source

    Journal of agricultural and food chemistry 55:4 2007 Feb 21 pg 1597-603

    MeSH

    Adult
    Carotenoids
    Cross-Over Studies
    Diet
    Female
    Fruit
    Humans
    Intestinal Absorption
    Lycopene
    Lycopersicon esculentum
    Male
    beta Carotene

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    17243700

    Citation

    Unlu, Nuray Z., et al. "Carotenoid Absorption in Humans Consuming Tomato Sauces Obtained From Tangerine or High-beta-carotene Varieties of Tomatoes." Journal of Agricultural and Food Chemistry, vol. 55, no. 4, 2007, pp. 1597-603.
    Unlu NZ, Bohn T, Francis D, et al. Carotenoid absorption in humans consuming tomato sauces obtained from tangerine or high-beta-carotene varieties of tomatoes. J Agric Food Chem. 2007;55(4):1597-603.
    Unlu, N. Z., Bohn, T., Francis, D., Clinton, S. K., & Schwartz, S. J. (2007). Carotenoid absorption in humans consuming tomato sauces obtained from tangerine or high-beta-carotene varieties of tomatoes. Journal of Agricultural and Food Chemistry, 55(4), pp. 1597-603.
    Unlu NZ, et al. Carotenoid Absorption in Humans Consuming Tomato Sauces Obtained From Tangerine or High-beta-carotene Varieties of Tomatoes. J Agric Food Chem. 2007 Feb 21;55(4):1597-603. PubMed PMID: 17243700.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Carotenoid absorption in humans consuming tomato sauces obtained from tangerine or high-beta-carotene varieties of tomatoes. AU - Unlu,Nuray Z, AU - Bohn,Torsten, AU - Francis,David, AU - Clinton,Steven K, AU - Schwartz,Steven J, Y1 - 2007/01/23/ PY - 2007/1/25/pubmed PY - 2007/6/7/medline PY - 2007/1/25/entrez SP - 1597 EP - 603 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 55 IS - 4 N2 - Tomato sauces were produced from unique tomato varieties to study carotenoid absorption in humans. Tangerine tomatoes, high in cis-lycopene, especially prolycopene (7Z,9Z,7'Z,9'Z), and high-beta-carotene tomatoes as an alternative dietary source of beta-carotene were grown and processed. Sauces were served after 2 week washout periods and overnight fasting for breakfast to healthy subjects (n = 12, 6M/6F) in a randomized crossover design. The serving size was 150 g (containing 15 g of corn oil), tangerine sauce containing 13 mg of lycopene (97.0% as cis-isomers) and high-beta-carotene sauce containing 17 mg of total beta-carotene (1.6% as the 9-cis-isomer) and 4 mg of lycopene. Blood samples were collected 0, 2, 3, 4, 5, 6, 8, and 9.5 h following test meal consumption and carotenoids determined in the plasma triacylglycerol-rich lipoprotein fraction by HPLC-electrochemical detection. Baseline-corrected areas under the concentration vs time curves (AUC) were used as a measure of absorption. AUC0-9.5h values for total lycopene in the tangerine sauce group were 870 +/- 187 (nmol.h)/L (mean +/- SEM) with >99% as cis-isomers (59% as the tetra-cis-isomer). The AUC0-9.5h values for total beta-carotene and lycopene after consumption of the high-beta-carotene sauce were 304 +/- 54 (4% as 9-cis-carotene) and 118 +/- 24 (nmol.h)/L, respectively. Lycopene dose-adjusted triacylglycerol-rich lipoprotein AUC responses in the tangerine sauce group were relatively high when compared to those in the literature and the high-beta-carotene group. The results support the hypothesis that lycopene cis-isomers are highly bioavailable and suggest that special tomato varieties can be utilized to increase both the intake and bioavailability of health-beneficial carotenoids. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/17243700/Carotenoid_absorption_in_humans_consuming_tomato_sauces_obtained_from_tangerine_or_high_beta_carotene_varieties_of_tomatoes_ L2 - https://dx.doi.org/10.1021/jf062337b DB - PRIME DP - Unbound Medicine ER -