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Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study.
Breast Cancer Res. 2007; 9(1):R9.BC

Abstract

INTRODUCTION

Vitamin D receptor (VDR) polymorphisms have been inconsistently associated with breast cancer risk. Whether risk is influenced by polymorphisms in other vitamin D metabolism genes and whether calcium or vitamin D intake modifies risk by genotype have not been evaluated.

METHODS

We conducted a nested case-control study within the Cancer Prevention Study II Nutrition Cohort of associations between breast cancer and four VDR single-nucleotide polymorphisms (SNPs), Bsm1,Apa1,Taq1, and Fok1, a poly(A) microsatellite, and associated haplotypes (baTL and BAtS). We also examined one SNP in the 24-hydroxylase gene (CYP24A1) and two in the vitamin D-binding protein (group-specific component [GC]) gene. Participants completed a questionnaire on diet and medical history at baseline in 1992. This study includes 500 postmenopausal breast cancer cases and 500 controls matched by age, race/ethnicity, and date of blood collection.

RESULTS

Incident breast cancer was not associated with any genotype examined. However, women with the Bsm1 bb SNP who consumed greater than the median intake of total calcium (> or = 902 mg/day) had lower odds of breast cancer compared to women with the Bb or BB genotype and less than the median calcium intake (odds ratio 0.61, 95% confidence interval 0.38 to 0.96; p(interaction) = 0.01). Similar interactions were observed for Taq1 (T allele) and the poly(A) (LL) repeat.

CONCLUSION

We found no overall association between selected vitamin D pathway genes and postmenopausal breast cancer risk. However, certain VDR gene polymorphisms were associated with lower risk in women consuming high levels of calcium, suggesting that dietary factors may modify associations by VDR genotype.

Authors+Show Affiliations

Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta, GA 30329, USA. marji.mccullough@cancer.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17244366

Citation

McCullough, Marjorie L., et al. "Vitamin D Pathway Gene Polymorphisms, Diet, and Risk of Postmenopausal Breast Cancer: a Nested Case-control Study." Breast Cancer Research : BCR, vol. 9, no. 1, 2007, pp. R9.
McCullough ML, Stevens VL, Diver WR, et al. Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study. Breast Cancer Res. 2007;9(1):R9.
McCullough, M. L., Stevens, V. L., Diver, W. R., Feigelson, H. S., Rodriguez, C., Bostick, R. M., Thun, M. J., & Calle, E. E. (2007). Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study. Breast Cancer Research : BCR, 9(1), R9.
McCullough ML, et al. Vitamin D Pathway Gene Polymorphisms, Diet, and Risk of Postmenopausal Breast Cancer: a Nested Case-control Study. Breast Cancer Res. 2007;9(1):R9. PubMed PMID: 17244366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study. AU - McCullough,Marjorie L, AU - Stevens,Victoria L, AU - Diver,William R, AU - Feigelson,Heather S, AU - Rodriguez,Carmen, AU - Bostick,Robin M, AU - Thun,Michael J, AU - Calle,Eugenia E, PY - 2006/10/03/received PY - 2006/12/12/revised PY - 2007/01/23/accepted PY - 2007/1/25/pubmed PY - 2007/5/11/medline PY - 2007/1/25/entrez SP - R9 EP - R9 JF - Breast cancer research : BCR JO - Breast Cancer Res. VL - 9 IS - 1 N2 - INTRODUCTION: Vitamin D receptor (VDR) polymorphisms have been inconsistently associated with breast cancer risk. Whether risk is influenced by polymorphisms in other vitamin D metabolism genes and whether calcium or vitamin D intake modifies risk by genotype have not been evaluated. METHODS: We conducted a nested case-control study within the Cancer Prevention Study II Nutrition Cohort of associations between breast cancer and four VDR single-nucleotide polymorphisms (SNPs), Bsm1,Apa1,Taq1, and Fok1, a poly(A) microsatellite, and associated haplotypes (baTL and BAtS). We also examined one SNP in the 24-hydroxylase gene (CYP24A1) and two in the vitamin D-binding protein (group-specific component [GC]) gene. Participants completed a questionnaire on diet and medical history at baseline in 1992. This study includes 500 postmenopausal breast cancer cases and 500 controls matched by age, race/ethnicity, and date of blood collection. RESULTS: Incident breast cancer was not associated with any genotype examined. However, women with the Bsm1 bb SNP who consumed greater than the median intake of total calcium (> or = 902 mg/day) had lower odds of breast cancer compared to women with the Bb or BB genotype and less than the median calcium intake (odds ratio 0.61, 95% confidence interval 0.38 to 0.96; p(interaction) = 0.01). Similar interactions were observed for Taq1 (T allele) and the poly(A) (LL) repeat. CONCLUSION: We found no overall association between selected vitamin D pathway genes and postmenopausal breast cancer risk. However, certain VDR gene polymorphisms were associated with lower risk in women consuming high levels of calcium, suggesting that dietary factors may modify associations by VDR genotype. SN - 1465-542X UR - https://www.unboundmedicine.com/medline/citation/17244366/Vitamin_D_pathway_gene_polymorphisms_diet_and_risk_of_postmenopausal_breast_cancer:_a_nested_case_control_study_ L2 - https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1642 DB - PRIME DP - Unbound Medicine ER -