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Contribution of tobacco and alcohol to the high rates of squamous cell carcinoma of the supraglottis and glottis in Central Europe.
Am J Epidemiol. 2007 Apr 01; 165(7):814-20.AJ

Abstract

Incidence rates for laryngeal cancer in Central Europe are among the highest in the world. The authors recruited cases and controls between 2000 and 2002 for the Central and Eastern Europe Multicenter Study to investigate the role of tobacco and alcohol as causes of laryngeal cancer in this region. A total of 384 incident squamous cell cases were included, comprising 254 glottic and 108 supraglottic cancers. Hospital controls were chosen from within the same catchment area, from diseases unrelated to tobacco or alcohol (n = 918). Significant dose-response trends for frequency and duration of tobacco use were observed for both supraglottic and glottic cancers, with potentially a more important effect for supraglottic cancer. Quitting smoking was protective against laryngeal cancers after 5 years. Any increases in risk for alcohol drinking were generally moderate and nonsignificant. A greater than multiplicative interaction was observed between tobacco and alcohol on the risk of laryngeal cancer (p = 0.04). Approximately 87% of laryngeal cancer cases in Central Europe are attributable to tobacco use, of which 75% and 12% are due to current and past smoking, respectively. Approximately 39% are attributable to the interaction between alcohol and tobacco. Preventive efforts to encourage current smokers to quit are likely to be the most effective way to reduce the incidence of laryngeal cancer in this region.

Authors+Show Affiliations

International Agency for Research on Cancer, Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17244634

Citation

Hashibe, Mia, et al. "Contribution of Tobacco and Alcohol to the High Rates of Squamous Cell Carcinoma of the Supraglottis and Glottis in Central Europe." American Journal of Epidemiology, vol. 165, no. 7, 2007, pp. 814-20.
Hashibe M, Boffetta P, Zaridze D, et al. Contribution of tobacco and alcohol to the high rates of squamous cell carcinoma of the supraglottis and glottis in Central Europe. Am J Epidemiol. 2007;165(7):814-20.
Hashibe, M., Boffetta, P., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Mates, D., Fabiánová, E., Rudnai, P., & Brennan, P. (2007). Contribution of tobacco and alcohol to the high rates of squamous cell carcinoma of the supraglottis and glottis in Central Europe. American Journal of Epidemiology, 165(7), 814-20.
Hashibe M, et al. Contribution of Tobacco and Alcohol to the High Rates of Squamous Cell Carcinoma of the Supraglottis and Glottis in Central Europe. Am J Epidemiol. 2007 Apr 1;165(7):814-20. PubMed PMID: 17244634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of tobacco and alcohol to the high rates of squamous cell carcinoma of the supraglottis and glottis in Central Europe. AU - Hashibe,Mia, AU - Boffetta,Paolo, AU - Zaridze,David, AU - Shangina,Oxana, AU - Szeszenia-Dabrowska,Neonila, AU - Mates,Dana, AU - Fabiánová,Eleonóra, AU - Rudnai,Peter, AU - Brennan,Paul, Y1 - 2007/01/22/ PY - 2007/1/25/pubmed PY - 2007/5/4/medline PY - 2007/1/25/entrez SP - 814 EP - 20 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 165 IS - 7 N2 - Incidence rates for laryngeal cancer in Central Europe are among the highest in the world. The authors recruited cases and controls between 2000 and 2002 for the Central and Eastern Europe Multicenter Study to investigate the role of tobacco and alcohol as causes of laryngeal cancer in this region. A total of 384 incident squamous cell cases were included, comprising 254 glottic and 108 supraglottic cancers. Hospital controls were chosen from within the same catchment area, from diseases unrelated to tobacco or alcohol (n = 918). Significant dose-response trends for frequency and duration of tobacco use were observed for both supraglottic and glottic cancers, with potentially a more important effect for supraglottic cancer. Quitting smoking was protective against laryngeal cancers after 5 years. Any increases in risk for alcohol drinking were generally moderate and nonsignificant. A greater than multiplicative interaction was observed between tobacco and alcohol on the risk of laryngeal cancer (p = 0.04). Approximately 87% of laryngeal cancer cases in Central Europe are attributable to tobacco use, of which 75% and 12% are due to current and past smoking, respectively. Approximately 39% are attributable to the interaction between alcohol and tobacco. Preventive efforts to encourage current smokers to quit are likely to be the most effective way to reduce the incidence of laryngeal cancer in this region. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/17244634/Contribution_of_tobacco_and_alcohol_to_the_high_rates_of_squamous_cell_carcinoma_of_the_supraglottis_and_glottis_in_Central_Europe_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwk066 DB - PRIME DP - Unbound Medicine ER -