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Specific features and roles of renal circulation: angiotensin II revisited.
J Physiol Pharmacol. 2006 Nov; 57 Suppl 11:169-78.JP

Abstract

The status of intrarenal circulation determines in part renal excretion, affects body fluid homeostasis and has a role in long term control of arterial blood pressure. The vascular resistance in the renal cortex and medulla is determined by interaction of a vast array of vasoactive hormones and paracrine factors; among these the role of constrictor angiotensin II and dilator prostaglandins and nitric oxide may appear to be dominating. The focus of this review and underlying studies is on the mechanisms whereby the microcirculation of the renal medulla is protected against the vasoconstrictor action of angiotensin II. In anaesthetized normal rats the three mentioned active agents or their inhibitors were applied and total renal blood flow and cortical, outer- and inner medullary laser-Doppler fluxes were determined; in some studies renal tissue nitric oxide was measured using selective electrodes. We conclude that angiotensin II, acting via AT1 receptors, constricts the renal cortical vasculature; in the medulla its action is effectively buffered by prostaglandin E2 but most probably not by nitric oxide.

Authors+Show Affiliations

Laboratory of Renal & Body Fluid Physiology, M. Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland. sadowski@cmdik.pan.plNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17244948

Citation

Sadowski, J, and B Badzyńska. "Specific Features and Roles of Renal Circulation: Angiotensin II Revisited." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 57 Suppl 11, 2006, pp. 169-78.
Sadowski J, Badzyńska B. Specific features and roles of renal circulation: angiotensin II revisited. J Physiol Pharmacol. 2006;57 Suppl 11:169-78.
Sadowski, J., & Badzyńska, B. (2006). Specific features and roles of renal circulation: angiotensin II revisited. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 57 Suppl 11, 169-78.
Sadowski J, Badzyńska B. Specific Features and Roles of Renal Circulation: Angiotensin II Revisited. J Physiol Pharmacol. 2006;57 Suppl 11:169-78. PubMed PMID: 17244948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific features and roles of renal circulation: angiotensin II revisited. AU - Sadowski,J, AU - Badzyńska,B, PY - 2006/11/21/received PY - 2006/11/24/accepted PY - 2007/1/25/pubmed PY - 2008/3/28/medline PY - 2007/1/25/entrez SP - 169 EP - 78 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 57 Suppl 11 N2 - The status of intrarenal circulation determines in part renal excretion, affects body fluid homeostasis and has a role in long term control of arterial blood pressure. The vascular resistance in the renal cortex and medulla is determined by interaction of a vast array of vasoactive hormones and paracrine factors; among these the role of constrictor angiotensin II and dilator prostaglandins and nitric oxide may appear to be dominating. The focus of this review and underlying studies is on the mechanisms whereby the microcirculation of the renal medulla is protected against the vasoconstrictor action of angiotensin II. In anaesthetized normal rats the three mentioned active agents or their inhibitors were applied and total renal blood flow and cortical, outer- and inner medullary laser-Doppler fluxes were determined; in some studies renal tissue nitric oxide was measured using selective electrodes. We conclude that angiotensin II, acting via AT1 receptors, constricts the renal cortical vasculature; in the medulla its action is effectively buffered by prostaglandin E2 but most probably not by nitric oxide. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/17244948/Specific_features_and_roles_of_renal_circulation:_angiotensin_II_revisited_ L2 - https://antibodies.cancer.gov/detail/CPTC-ATM-4 DB - PRIME DP - Unbound Medicine ER -