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Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristics.
J Clin Gastroenterol. 2007 Feb; 41(2):131-7.JC

Abstract

Nonerosive reflux disease (NERD) and erosive esophagitis are the main presentations of gastroesophageal reflux disease. However, NERD is the most common presentation of gastroesophageal reflux disease in community-based patients. Patients with NERD differ in demographic characteristics from patients with erosive esophagitis, primarily in sex distribution, weight/body mass index, and prevalence of hiatal hernia. Physiologically, patients with NERD tend to have normal lower esophageal sphincter resting pressure, minimal esophageal body motility abnormalities, low esophageal acid exposure profile and minimal nighttime esophageal acid exposure. Patients with NERD have a lower symptom response rate to proton pump inhibitor once daily than patients with erosive esophagitis. Additionally, NERD patients demonstrate a longer lag-time for symptom resolution and lack of difference in symptom response rate between half to full dose proton pump inhibitor as compared with patients with erosive esophagitis.

Authors+Show Affiliations

The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723-0001, USA. Ronnie.Fass@med.VA.gov

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17245209

Citation

Fass, Ronnie. "Erosive Esophagitis and Nonerosive Reflux Disease (NERD): Comparison of Epidemiologic, Physiologic, and Therapeutic Characteristics." Journal of Clinical Gastroenterology, vol. 41, no. 2, 2007, pp. 131-7.
Fass R. Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristics. J Clin Gastroenterol. 2007;41(2):131-7.
Fass, R. (2007). Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristics. Journal of Clinical Gastroenterology, 41(2), 131-7.
Fass R. Erosive Esophagitis and Nonerosive Reflux Disease (NERD): Comparison of Epidemiologic, Physiologic, and Therapeutic Characteristics. J Clin Gastroenterol. 2007;41(2):131-7. PubMed PMID: 17245209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristics. A1 - Fass,Ronnie, PY - 2007/1/25/pubmed PY - 2007/3/9/medline PY - 2007/1/25/entrez SP - 131 EP - 7 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 41 IS - 2 N2 - Nonerosive reflux disease (NERD) and erosive esophagitis are the main presentations of gastroesophageal reflux disease. However, NERD is the most common presentation of gastroesophageal reflux disease in community-based patients. Patients with NERD differ in demographic characteristics from patients with erosive esophagitis, primarily in sex distribution, weight/body mass index, and prevalence of hiatal hernia. Physiologically, patients with NERD tend to have normal lower esophageal sphincter resting pressure, minimal esophageal body motility abnormalities, low esophageal acid exposure profile and minimal nighttime esophageal acid exposure. Patients with NERD have a lower symptom response rate to proton pump inhibitor once daily than patients with erosive esophagitis. Additionally, NERD patients demonstrate a longer lag-time for symptom resolution and lack of difference in symptom response rate between half to full dose proton pump inhibitor as compared with patients with erosive esophagitis. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/17245209/Erosive_esophagitis_and_nonerosive_reflux_disease__NERD_:_comparison_of_epidemiologic_physiologic_and_therapeutic_characteristics_ L2 - http://dx.doi.org/10.1097/01.mcg.0000225631.07039.6d DB - PRIME DP - Unbound Medicine ER -
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