Type your tag names separated by a space and hit enter

Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years.

Abstract

Fifty seven hospital workers received influenza vaccine in November 2003, and the serum HI antibody titer was determined before, 2 and 4 weeks after the vaccination. Thirty seven were vaccinated in November, 2002 consecutively (the repeated vaccination group), and the remaining 20 had not been vaccinated in the previous year (the single vaccination group). Six of the repeated vaccination group received both influenza and hepatitis B vaccination in September, 2004 and the antibody responses were examined 2 weeks later. Two and four weeks after the 2003-vaccination, the HI antibody titers to A/H1N1, A/H3N2, and B in the repeated vaccination group were significantly lower than in the single vaccination group (P < 0.05). This phenomenon had no relation to the pre-vaccination HI antibody titer. The antibody response was low to repeated influenza vaccination, but normal to hepatitis B vaccine in six subjects who had a second vaccination in 2004, showing that this depressed response was influenza-specific. These results suggest that the decreased HI antibody response to repeated influenza vaccination was affected mainly by the previous vaccination per se rather than by the pre-existing antibody titer.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of General Medicine, Kyushu University Hospital, Fukuoka, Japan. snabeshi@minf.med.fukuoka-u.ac.jp

    , , , ,

    Source

    Journal of medical virology 79:3 2007 Mar pg 320-5

    MeSH

    Adult
    Antibodies, Viral
    Hemagglutination Inhibition Tests
    Hepatitis B Antibodies
    Hepatitis B Vaccines
    Humans
    Immunization, Secondary
    Influenza A Virus, H1N1 Subtype
    Influenza A Virus, H3N2 Subtype
    Influenza A virus
    Influenza B virus
    Influenza Vaccines
    Middle Aged

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17245715

    Citation

    Nabeshima, Shigeki, et al. "Antibody Response to Influenza Vaccine in Adults Vaccinated With Identical Vaccine Strains in Consecutive Years." Journal of Medical Virology, vol. 79, no. 3, 2007, pp. 320-5.
    Nabeshima S, Kashiwagi K, Murata M, et al. Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years. J Med Virol. 2007;79(3):320-5.
    Nabeshima, S., Kashiwagi, K., Murata, M., Kanamoto, Y., Furusyo, N., & Hayashi, J. (2007). Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years. Journal of Medical Virology, 79(3), pp. 320-5.
    Nabeshima S, et al. Antibody Response to Influenza Vaccine in Adults Vaccinated With Identical Vaccine Strains in Consecutive Years. J Med Virol. 2007;79(3):320-5. PubMed PMID: 17245715.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years. AU - Nabeshima,Shigeki, AU - Kashiwagi,Kenichiro, AU - Murata,Masayuki, AU - Kanamoto,Yoko, AU - Furusyo,Norihiro, AU - Hayashi,Jun, PY - 2007/1/25/pubmed PY - 2007/7/21/medline PY - 2007/1/25/entrez SP - 320 EP - 5 JF - Journal of medical virology JO - J. Med. Virol. VL - 79 IS - 3 N2 - Fifty seven hospital workers received influenza vaccine in November 2003, and the serum HI antibody titer was determined before, 2 and 4 weeks after the vaccination. Thirty seven were vaccinated in November, 2002 consecutively (the repeated vaccination group), and the remaining 20 had not been vaccinated in the previous year (the single vaccination group). Six of the repeated vaccination group received both influenza and hepatitis B vaccination in September, 2004 and the antibody responses were examined 2 weeks later. Two and four weeks after the 2003-vaccination, the HI antibody titers to A/H1N1, A/H3N2, and B in the repeated vaccination group were significantly lower than in the single vaccination group (P < 0.05). This phenomenon had no relation to the pre-vaccination HI antibody titer. The antibody response was low to repeated influenza vaccination, but normal to hepatitis B vaccine in six subjects who had a second vaccination in 2004, showing that this depressed response was influenza-specific. These results suggest that the decreased HI antibody response to repeated influenza vaccination was affected mainly by the previous vaccination per se rather than by the pre-existing antibody titer. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/17245715/Antibody_response_to_influenza_vaccine_in_adults_vaccinated_with_identical_vaccine_strains_in_consecutive_years_ L2 - https://doi.org/10.1002/jmv.20801 DB - PRIME DP - Unbound Medicine ER -