Tags

Type your tag names separated by a space and hit enter

Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years.
J Med Virol 2007; 79(3):320-5JM

Abstract

Fifty seven hospital workers received influenza vaccine in November 2003, and the serum HI antibody titer was determined before, 2 and 4 weeks after the vaccination. Thirty seven were vaccinated in November, 2002 consecutively (the repeated vaccination group), and the remaining 20 had not been vaccinated in the previous year (the single vaccination group). Six of the repeated vaccination group received both influenza and hepatitis B vaccination in September, 2004 and the antibody responses were examined 2 weeks later. Two and four weeks after the 2003-vaccination, the HI antibody titers to A/H1N1, A/H3N2, and B in the repeated vaccination group were significantly lower than in the single vaccination group (P < 0.05). This phenomenon had no relation to the pre-vaccination HI antibody titer. The antibody response was low to repeated influenza vaccination, but normal to hepatitis B vaccine in six subjects who had a second vaccination in 2004, showing that this depressed response was influenza-specific. These results suggest that the decreased HI antibody response to repeated influenza vaccination was affected mainly by the previous vaccination per se rather than by the pre-existing antibody titer.

Authors+Show Affiliations

Department of General Medicine, Kyushu University Hospital, Fukuoka, Japan. snabeshi@minf.med.fukuoka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17245715

Citation

Nabeshima, Shigeki, et al. "Antibody Response to Influenza Vaccine in Adults Vaccinated With Identical Vaccine Strains in Consecutive Years." Journal of Medical Virology, vol. 79, no. 3, 2007, pp. 320-5.
Nabeshima S, Kashiwagi K, Murata M, et al. Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years. J Med Virol. 2007;79(3):320-5.
Nabeshima, S., Kashiwagi, K., Murata, M., Kanamoto, Y., Furusyo, N., & Hayashi, J. (2007). Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years. Journal of Medical Virology, 79(3), pp. 320-5.
Nabeshima S, et al. Antibody Response to Influenza Vaccine in Adults Vaccinated With Identical Vaccine Strains in Consecutive Years. J Med Virol. 2007;79(3):320-5. PubMed PMID: 17245715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years. AU - Nabeshima,Shigeki, AU - Kashiwagi,Kenichiro, AU - Murata,Masayuki, AU - Kanamoto,Yoko, AU - Furusyo,Norihiro, AU - Hayashi,Jun, PY - 2007/1/25/pubmed PY - 2007/7/21/medline PY - 2007/1/25/entrez SP - 320 EP - 5 JF - Journal of medical virology JO - J. Med. Virol. VL - 79 IS - 3 N2 - Fifty seven hospital workers received influenza vaccine in November 2003, and the serum HI antibody titer was determined before, 2 and 4 weeks after the vaccination. Thirty seven were vaccinated in November, 2002 consecutively (the repeated vaccination group), and the remaining 20 had not been vaccinated in the previous year (the single vaccination group). Six of the repeated vaccination group received both influenza and hepatitis B vaccination in September, 2004 and the antibody responses were examined 2 weeks later. Two and four weeks after the 2003-vaccination, the HI antibody titers to A/H1N1, A/H3N2, and B in the repeated vaccination group were significantly lower than in the single vaccination group (P < 0.05). This phenomenon had no relation to the pre-vaccination HI antibody titer. The antibody response was low to repeated influenza vaccination, but normal to hepatitis B vaccine in six subjects who had a second vaccination in 2004, showing that this depressed response was influenza-specific. These results suggest that the decreased HI antibody response to repeated influenza vaccination was affected mainly by the previous vaccination per se rather than by the pre-existing antibody titer. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/17245715/Antibody_response_to_influenza_vaccine_in_adults_vaccinated_with_identical_vaccine_strains_in_consecutive_years_ L2 - https://doi.org/10.1002/jmv.20801 DB - PRIME DP - Unbound Medicine ER -