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An improved method validation for rapid determination of acrylamide in foods by ultra-performance liquid chromatography combined with tandem mass spectrometry.
J Chromatogr A. 2007 Feb 23; 1142(2):194-8.JC

Abstract

An improved method was validated for the determination of acrylamide in foods using ultra-performance liquid chromatography (UPLC) coupled to eletrospray ionization tandem mass spectrometry (MS/MS) in the present study. This improved method supplies a rapid quantitative procedure of acrylamide with a run time of only 3 min. Results showed a good repeatability (RSD< or =4.5%) with 50, 100, 250, 500 and 1000 microg/kg spiked concentrations in potato crisps in within-day (n=5) and day-to-day (n=10) precision tests. Meanwhile, good recoveries (81.6-99.0%) were obtained with the same spiked concentrations in acrylamide-free cereal samples (n=3). The excellent method validation data and proficiency test results (Z-score: -0.1) of the official Food Analysis Performance Assessment Scheme (FAPAS) suggested that the present quantitative method could be applied for rapid determination of acrylamide in many investigations.

Authors+Show Affiliations

Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310029, Zhejiang Province, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

17250842

Citation

Zhang, Yu, et al. "An Improved Method Validation for Rapid Determination of Acrylamide in Foods By Ultra-performance Liquid Chromatography Combined With Tandem Mass Spectrometry." Journal of Chromatography. A, vol. 1142, no. 2, 2007, pp. 194-8.
Zhang Y, Jiao J, Cai Z, et al. An improved method validation for rapid determination of acrylamide in foods by ultra-performance liquid chromatography combined with tandem mass spectrometry. J Chromatogr A. 2007;1142(2):194-8.
Zhang, Y., Jiao, J., Cai, Z., Zhang, Y., & Ren, Y. (2007). An improved method validation for rapid determination of acrylamide in foods by ultra-performance liquid chromatography combined with tandem mass spectrometry. Journal of Chromatography. A, 1142(2), 194-8.
Zhang Y, et al. An Improved Method Validation for Rapid Determination of Acrylamide in Foods By Ultra-performance Liquid Chromatography Combined With Tandem Mass Spectrometry. J Chromatogr A. 2007 Feb 23;1142(2):194-8. PubMed PMID: 17250842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An improved method validation for rapid determination of acrylamide in foods by ultra-performance liquid chromatography combined with tandem mass spectrometry. AU - Zhang,Yu, AU - Jiao,Jingjing, AU - Cai,Zengxuan, AU - Zhang,Ying, AU - Ren,Yiping, Y1 - 2006/12/27/ PY - 2006/10/23/received PY - 2006/12/08/revised PY - 2006/12/15/accepted PY - 2007/1/26/pubmed PY - 2007/3/27/medline PY - 2007/1/26/entrez SP - 194 EP - 8 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1142 IS - 2 N2 - An improved method was validated for the determination of acrylamide in foods using ultra-performance liquid chromatography (UPLC) coupled to eletrospray ionization tandem mass spectrometry (MS/MS) in the present study. This improved method supplies a rapid quantitative procedure of acrylamide with a run time of only 3 min. Results showed a good repeatability (RSD< or =4.5%) with 50, 100, 250, 500 and 1000 microg/kg spiked concentrations in potato crisps in within-day (n=5) and day-to-day (n=10) precision tests. Meanwhile, good recoveries (81.6-99.0%) were obtained with the same spiked concentrations in acrylamide-free cereal samples (n=3). The excellent method validation data and proficiency test results (Z-score: -0.1) of the official Food Analysis Performance Assessment Scheme (FAPAS) suggested that the present quantitative method could be applied for rapid determination of acrylamide in many investigations. SN - 0021-9673 UR - https://www.unboundmedicine.com/medline/citation/17250842/An_improved_method_validation_for_rapid_determination_of_acrylamide_in_foods_by_ultra_performance_liquid_chromatography_combined_with_tandem_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(06)02380-6 DB - PRIME DP - Unbound Medicine ER -