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Differential contributions of dorsal vs. ventral hippocampus to auditory trace fear conditioning.
Neurobiol Learn Mem. 2007 May; 87(4):464-75.NL

Abstract

The effect of excitotoxic lesions of dorsal vs. ventral hippocampus on the acquisition and expression of auditory trace fear conditioning was examined in two studies. In Experiment 1, animals received excitotoxic lesions of either the dorsal or ventral hippocampus or sham surgeries one week prior to conditioning, and were tested 24 h later. In Experiment 2, animals received excitotoxic lesions of either the dorsal or ventral hippocampus or sham surgeries 24 h after training, and were tested one week after surgery. Both pre- and post-training lesions of ventral hippocampus impaired the acquisition and expression, respectively, of auditory trace fear conditioning. Pre-training lesions of dorsal hippocampus had no effect on the acquisition of trace fear conditioning, while post-training lesions of dorsal hippocampus dramatically impaired expression during subsequent testing. Although in some cases animals with lesions of ventral hippocampus exhibited locomotor hyperactivity, it is unlikely that the pattern of observed deficits can be attributed to this effect. Collectively these data suggest that the dorsal and ventral hippocampus may contribute differentially to the mnemonic processes underlying fear trace conditioning.

Authors+Show Affiliations

Program in Behavioral Neuroscience, Department of Psychology, Rutgers University, New Brunswick, NJ 08854, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17251041

Citation

Yoon, Taejib, and Tim Otto. "Differential Contributions of Dorsal Vs. Ventral Hippocampus to Auditory Trace Fear Conditioning." Neurobiology of Learning and Memory, vol. 87, no. 4, 2007, pp. 464-75.
Yoon T, Otto T. Differential contributions of dorsal vs. ventral hippocampus to auditory trace fear conditioning. Neurobiol Learn Mem. 2007;87(4):464-75.
Yoon, T., & Otto, T. (2007). Differential contributions of dorsal vs. ventral hippocampus to auditory trace fear conditioning. Neurobiology of Learning and Memory, 87(4), 464-75.
Yoon T, Otto T. Differential Contributions of Dorsal Vs. Ventral Hippocampus to Auditory Trace Fear Conditioning. Neurobiol Learn Mem. 2007;87(4):464-75. PubMed PMID: 17251041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential contributions of dorsal vs. ventral hippocampus to auditory trace fear conditioning. AU - Yoon,Taejib, AU - Otto,Tim, Y1 - 2007/01/23/ PY - 2006/03/29/received PY - 2006/11/06/revised PY - 2006/12/06/accepted PY - 2007/1/26/pubmed PY - 2007/7/17/medline PY - 2007/1/26/entrez SP - 464 EP - 75 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 87 IS - 4 N2 - The effect of excitotoxic lesions of dorsal vs. ventral hippocampus on the acquisition and expression of auditory trace fear conditioning was examined in two studies. In Experiment 1, animals received excitotoxic lesions of either the dorsal or ventral hippocampus or sham surgeries one week prior to conditioning, and were tested 24 h later. In Experiment 2, animals received excitotoxic lesions of either the dorsal or ventral hippocampus or sham surgeries 24 h after training, and were tested one week after surgery. Both pre- and post-training lesions of ventral hippocampus impaired the acquisition and expression, respectively, of auditory trace fear conditioning. Pre-training lesions of dorsal hippocampus had no effect on the acquisition of trace fear conditioning, while post-training lesions of dorsal hippocampus dramatically impaired expression during subsequent testing. Although in some cases animals with lesions of ventral hippocampus exhibited locomotor hyperactivity, it is unlikely that the pattern of observed deficits can be attributed to this effect. Collectively these data suggest that the dorsal and ventral hippocampus may contribute differentially to the mnemonic processes underlying fear trace conditioning. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/17251041/Differential_contributions_of_dorsal_vs__ventral_hippocampus_to_auditory_trace_fear_conditioning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(06)00169-9 DB - PRIME DP - Unbound Medicine ER -