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Type 2 diabetes and the risk of Parkinson's disease.
Diabetes Care. 2007 Apr; 30(4):842-7.DC

Abstract

OBJECTIVE

To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease.

RESEARCH DESIGN AND METHODS

We prospectively followed 51,552 Finnish men and women 25-74 years of age without a history of Parkinson's disease at baseline. History of diabetes and other study parameters were determined at baseline using standardized measurements. Ascertainment of the Parkinson's disease status was based on the nationwide Social Insurance Institution's drug register data. Hazard ratios of incident Parkinson's disease associated with the history of type 2 diabetes were estimated.

RESULTS

During a mean follow-up period of 18.0 years, 324 men and 309 women developed incident Parkinson's disease. Age- and study year-adjusted hazard ratios of incident Parkinson's disease among subjects with type 2 diabetes, compared with those without it, were 1.80 (95% CI 1.03-3.15) in men, 1.93 (1.05-3.53) in women, and 1.85 (1.23-2.80) in men and women combined (adjusted also for sex). Further adjustment for BMI, systolic blood pressure, total cholesterol, education, leisure-time physical activity, smoking, alcohol drinking, and coffee and tea consumption affected the results only slightly. The multivariate adjusted association between type 2 diabetes and the risk of Parkinson's disease was also confirmed in stratified subgroup analysis.

CONCLUSIONS

These data suggest that type 2 diabetes is associated with an increased risk of Parkinson's disease. Surveillance bias might account for higher rates in diabetes. The mechanism behind this association between diabetes and Parkinson's disease is not known.

Authors+Show Affiliations

Department of Health Promotion and Chronic Diseases Prevention, National Public Health Institute, Helsinki, Finland. hu.gang@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17251276

Citation

Hu, Gang, et al. "Type 2 Diabetes and the Risk of Parkinson's Disease." Diabetes Care, vol. 30, no. 4, 2007, pp. 842-7.
Hu G, Jousilahti P, Bidel S, et al. Type 2 diabetes and the risk of Parkinson's disease. Diabetes Care. 2007;30(4):842-7.
Hu, G., Jousilahti, P., Bidel, S., Antikainen, R., & Tuomilehto, J. (2007). Type 2 diabetes and the risk of Parkinson's disease. Diabetes Care, 30(4), 842-7.
Hu G, et al. Type 2 Diabetes and the Risk of Parkinson's Disease. Diabetes Care. 2007;30(4):842-7. PubMed PMID: 17251276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Type 2 diabetes and the risk of Parkinson's disease. AU - Hu,Gang, AU - Jousilahti,Pekka, AU - Bidel,Siamak, AU - Antikainen,Riitta, AU - Tuomilehto,Jaakko, Y1 - 2007/01/24/ PY - 2007/1/26/pubmed PY - 2007/6/15/medline PY - 2007/1/26/entrez SP - 842 EP - 7 JF - Diabetes care JO - Diabetes Care VL - 30 IS - 4 N2 - OBJECTIVE: To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease. RESEARCH DESIGN AND METHODS: We prospectively followed 51,552 Finnish men and women 25-74 years of age without a history of Parkinson's disease at baseline. History of diabetes and other study parameters were determined at baseline using standardized measurements. Ascertainment of the Parkinson's disease status was based on the nationwide Social Insurance Institution's drug register data. Hazard ratios of incident Parkinson's disease associated with the history of type 2 diabetes were estimated. RESULTS: During a mean follow-up period of 18.0 years, 324 men and 309 women developed incident Parkinson's disease. Age- and study year-adjusted hazard ratios of incident Parkinson's disease among subjects with type 2 diabetes, compared with those without it, were 1.80 (95% CI 1.03-3.15) in men, 1.93 (1.05-3.53) in women, and 1.85 (1.23-2.80) in men and women combined (adjusted also for sex). Further adjustment for BMI, systolic blood pressure, total cholesterol, education, leisure-time physical activity, smoking, alcohol drinking, and coffee and tea consumption affected the results only slightly. The multivariate adjusted association between type 2 diabetes and the risk of Parkinson's disease was also confirmed in stratified subgroup analysis. CONCLUSIONS: These data suggest that type 2 diabetes is associated with an increased risk of Parkinson's disease. Surveillance bias might account for higher rates in diabetes. The mechanism behind this association between diabetes and Parkinson's disease is not known. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/17251276/Type_2_diabetes_and_the_risk_of_Parkinson's_disease_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=17251276 DB - PRIME DP - Unbound Medicine ER -