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Abnormal deposition of collagen/elastic vascular fibres and prognostic significance in idiopathic interstitial pneumonias.
Thorax. 2007 May; 62(5):428-37.T

Abstract

BACKGROUND

Vascular remodelling has recently been shown to be a promising pathogenetic indicator in idiopathic interstitial pneumonias (IIPs).

AIM

To validate the importance of the collagen/elastic system in vascular remodelling and to study the relationships between the collagen/elastic system, survival and the major histological patterns of IIPs.

METHODS

Collagen/elastic system fibres were studied in 25 patients with acute interstitial pneumonia/diffuse alveolar damage, 22 with non-specific interstitial pneumonia/non-specific interstitial pneumonia and 55 with idiopathic pulmonary fibrosis/usual interstitial pneumonia. The Picrosirius polarisation method and Weigert's resorcin-fuchsin histochemistry and morphometric analysis were used to evaluate the amount of vascular collagen/elastic system fibres and their association with the histological pattern of IIPs. The association between vascular remodelling and the degree of parenchymal fibrosis in usual interstitial pneumonia (UIP) was also considered.

RESULTS

The vascular measurement of collagen/elastic fibres was significantly higher in UIP than in the lungs of controls, and in those with diffuse alveolar damage and those with non-specific interstitial pneumonia. In addition, the increment of collagen/elastic fibres in UIP varied according to the degree and activity of the parenchymal fibrosis. The most important predictors of survival in UIP were vascular remodelling classification and vascular collagen deposition.

CONCLUSION

A progressive vascular fibroelastosis occurs in IIP histological patterns, probably indicating evolutionarily adapted responses to parenchymal injury. The vascular remodelling classification and the increase in vascular collagen were related to survival in IIP and possibly play a role in its pathogenesis. Further studies are needed to determine whether this relationship is causal or consequential.

Authors+Show Affiliations

Department of Pathology, Sao Paulo Medical School, University of São Paulo, Dr Arnaldo Avenue 455, São Paulo 01246-903, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17251318

Citation

Parra, Edwin Roger, et al. "Abnormal Deposition of Collagen/elastic Vascular Fibres and Prognostic Significance in Idiopathic Interstitial Pneumonias." Thorax, vol. 62, no. 5, 2007, pp. 428-37.
Parra ER, Kairalla RA, de Carvalho CR, et al. Abnormal deposition of collagen/elastic vascular fibres and prognostic significance in idiopathic interstitial pneumonias. Thorax. 2007;62(5):428-37.
Parra, E. R., Kairalla, R. A., de Carvalho, C. R., & Capelozzi, V. L. (2007). Abnormal deposition of collagen/elastic vascular fibres and prognostic significance in idiopathic interstitial pneumonias. Thorax, 62(5), 428-37.
Parra ER, et al. Abnormal Deposition of Collagen/elastic Vascular Fibres and Prognostic Significance in Idiopathic Interstitial Pneumonias. Thorax. 2007;62(5):428-37. PubMed PMID: 17251318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal deposition of collagen/elastic vascular fibres and prognostic significance in idiopathic interstitial pneumonias. AU - Parra,Edwin Roger, AU - Kairalla,Ronaldo Adib, AU - de Carvalho,Carlos Roberto Ribeiro, AU - Capelozzi,Vera Luiza, Y1 - 2007/01/24/ PY - 2007/1/26/pubmed PY - 2007/5/30/medline PY - 2007/1/26/entrez SP - 428 EP - 37 JF - Thorax JO - Thorax VL - 62 IS - 5 N2 - BACKGROUND: Vascular remodelling has recently been shown to be a promising pathogenetic indicator in idiopathic interstitial pneumonias (IIPs). AIM: To validate the importance of the collagen/elastic system in vascular remodelling and to study the relationships between the collagen/elastic system, survival and the major histological patterns of IIPs. METHODS: Collagen/elastic system fibres were studied in 25 patients with acute interstitial pneumonia/diffuse alveolar damage, 22 with non-specific interstitial pneumonia/non-specific interstitial pneumonia and 55 with idiopathic pulmonary fibrosis/usual interstitial pneumonia. The Picrosirius polarisation method and Weigert's resorcin-fuchsin histochemistry and morphometric analysis were used to evaluate the amount of vascular collagen/elastic system fibres and their association with the histological pattern of IIPs. The association between vascular remodelling and the degree of parenchymal fibrosis in usual interstitial pneumonia (UIP) was also considered. RESULTS: The vascular measurement of collagen/elastic fibres was significantly higher in UIP than in the lungs of controls, and in those with diffuse alveolar damage and those with non-specific interstitial pneumonia. In addition, the increment of collagen/elastic fibres in UIP varied according to the degree and activity of the parenchymal fibrosis. The most important predictors of survival in UIP were vascular remodelling classification and vascular collagen deposition. CONCLUSION: A progressive vascular fibroelastosis occurs in IIP histological patterns, probably indicating evolutionarily adapted responses to parenchymal injury. The vascular remodelling classification and the increase in vascular collagen were related to survival in IIP and possibly play a role in its pathogenesis. Further studies are needed to determine whether this relationship is causal or consequential. SN - 0040-6376 UR - https://www.unboundmedicine.com/medline/citation/17251318/Abnormal_deposition_of_collagen/elastic_vascular_fibres_and_prognostic_significance_in_idiopathic_interstitial_pneumonias_ L2 - http://thorax.bmj.com/cgi/pmidlookup?view=long&pmid=17251318 DB - PRIME DP - Unbound Medicine ER -