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Penetrating keratoplasty for corneal perforations in fungal keratitis.
Cornea 2007; 26(2):158-62C

Abstract

PURPOSE

To evaluate the complications and therapeutic effects of penetrating keratoplasty (PKP) in the treatment of corneal perforations in fungal keratitis.

METHODS

The medical records of patients who underwent PKP for corneal perforations in fungal keratitis at Shandong Eye Institute from January 1999 to December 2004 were retrospectively reviewed.

RESULTS

Fifty-two patients (52 eyes) were included in this study. Twenty eyes (38.5%) had graft rejection after primary PKP, 12 of which were medically treated, and 8 underwent secondary PKP with 4 acquiring clear grafts. Fungal infection recurred in 8 eyes (15.4%), 3 of which were controlled with antifungal agents, 3 were treated with secondary PKP, and 2 were enucleated. Ten eyes (19.2%) with complicated cataract underwent intraoperative or postoperative extracapsular cataract extraction. Seven eyes (13.5%) with secondary glaucoma were cured. Graft ulcer occurred in 5 eyes (9.6%), 3 of which were cured with amniotic membrane transplantation and 2 with medications. Forty-four grafts (84.6%) remained clear at final follow-up, and 46 eyes (88.5%) had improved visual acuity.

CONCLUSION

Although many complications may occur, therapeutic PKP seems to be effective in the treatment of fungal keratitis with corneal perforation.

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    Authors+Show Affiliations

    Xie L
    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China. lixinxie@public.qd.sd.cn
    Zhai H
    No affiliation info available
    Shi W
    No affiliation info available

    MeSH

    AdolescentAdultAgedChildCorneaEye Infections, FungalFemaleFollow-Up StudiesGraft SurvivalHumansKeratitisKeratoplasty, PenetratingMaleMiddle AgedRetrospective StudiesRisk FactorsRupture, SpontaneousTreatment OutcomeVisual Acuity

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17251805

    Citation

    Xie, Lixin, et al. "Penetrating Keratoplasty for Corneal Perforations in Fungal Keratitis." Cornea, vol. 26, no. 2, 2007, pp. 158-62.
    Xie L, Zhai H, Shi W. Penetrating keratoplasty for corneal perforations in fungal keratitis. Cornea. 2007;26(2):158-62.
    Xie, L., Zhai, H., & Shi, W. (2007). Penetrating keratoplasty for corneal perforations in fungal keratitis. Cornea, 26(2), pp. 158-62.
    Xie L, Zhai H, Shi W. Penetrating Keratoplasty for Corneal Perforations in Fungal Keratitis. Cornea. 2007;26(2):158-62. PubMed PMID: 17251805.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Penetrating keratoplasty for corneal perforations in fungal keratitis. AU - Xie,Lixin, AU - Zhai,Hualei, AU - Shi,Weiyun, PY - 2007/1/26/pubmed PY - 2007/3/9/medline PY - 2007/1/26/entrez SP - 158 EP - 62 JF - Cornea JO - Cornea VL - 26 IS - 2 N2 - PURPOSE: To evaluate the complications and therapeutic effects of penetrating keratoplasty (PKP) in the treatment of corneal perforations in fungal keratitis. METHODS: The medical records of patients who underwent PKP for corneal perforations in fungal keratitis at Shandong Eye Institute from January 1999 to December 2004 were retrospectively reviewed. RESULTS: Fifty-two patients (52 eyes) were included in this study. Twenty eyes (38.5%) had graft rejection after primary PKP, 12 of which were medically treated, and 8 underwent secondary PKP with 4 acquiring clear grafts. Fungal infection recurred in 8 eyes (15.4%), 3 of which were controlled with antifungal agents, 3 were treated with secondary PKP, and 2 were enucleated. Ten eyes (19.2%) with complicated cataract underwent intraoperative or postoperative extracapsular cataract extraction. Seven eyes (13.5%) with secondary glaucoma were cured. Graft ulcer occurred in 5 eyes (9.6%), 3 of which were cured with amniotic membrane transplantation and 2 with medications. Forty-four grafts (84.6%) remained clear at final follow-up, and 46 eyes (88.5%) had improved visual acuity. CONCLUSION: Although many complications may occur, therapeutic PKP seems to be effective in the treatment of fungal keratitis with corneal perforation. SN - 0277-3740 UR - https://www.unboundmedicine.com/medline/citation/17251805/Penetrating_keratoplasty_for_corneal_perforations_in_fungal_keratitis_ L2 - http://Insights.ovid.com/pubmed?pmid=17251805 DB - PRIME DP - Unbound Medicine ER -