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Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi.
J Nat Prod. 2007 Jan; 70(1):9-13.JN

Abstract

The dicholoromethane extract of Pseudocedrela kotschyi root demonstrated marked antileishmanial properties in preliminary screening of extracts from 21 species commonly used in Malian traditional medicine. Phytochemical investigation of the active extract yielded three novel phragmalin-type limonoid orthoacetates (1-3), named kotschyins A-C, and the known compounds 7-deacetylgedunin (4) and 7-deacetyl-7-oxogedunin (5). The structures of 1-3 were elucidated by analytical methods including 1D- and 2D-NMR spectroscopy together with MS spectroscopy. The relative configurations of 1-3 were assigned on the basis of NOE correlations. The extract and the isolated compounds were tested for their antiprotozoal activities against Leishmania donovani, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, and Plasmodium falciparum as well as for cytotoxicity toward the L-6 cell line. The crude extract and the two gedunin derivatives exhibited good in vitro activity against all of these parasites.

Authors+Show Affiliations

Hay AE
Laboratory of Pharmacognosy and Phytochemistry, Geneva-Lausanne School of Pharmacy, University of Geneva, CH-1211 Geneva 4, Switzerland.
Ioset JR
No affiliation info available
Ahua KM
No affiliation info available
Diallo D
No affiliation info available
Brun R
No affiliation info available
Hostettmann K
No affiliation info available

MeSH

AnimalsAntiprotozoal AgentsLeishmania donovaniLimoninsMaliMeliaceaeMolecular StructurePlant RootsPlants, MedicinalPlasmodium falciparumTrypanosoma brucei rhodesienseTrypanosoma cruzi

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17253841

Citation

Hay, Anne-Emmanuelle, et al. "Limonoid Orthoacetates and Antiprotozoal Compounds From the Roots of Pseudocedrela Kotschyi." Journal of Natural Products, vol. 70, no. 1, 2007, pp. 9-13.
Hay AE, Ioset JR, Ahua KM, et al. Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi. J Nat Prod. 2007;70(1):9-13.
Hay, A. E., Ioset, J. R., Ahua, K. M., Diallo, D., Brun, R., & Hostettmann, K. (2007). Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi. Journal of Natural Products, 70(1), 9-13.
Hay AE, et al. Limonoid Orthoacetates and Antiprotozoal Compounds From the Roots of Pseudocedrela Kotschyi. J Nat Prod. 2007;70(1):9-13. PubMed PMID: 17253841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi. AU - Hay,Anne-Emmanuelle, AU - Ioset,Jean-Robert, AU - Ahua,Kouassi Maximin, AU - Diallo,Drissa, AU - Brun,Reto, AU - Hostettmann,Kurt, PY - 2007/1/27/pubmed PY - 2007/3/8/medline PY - 2007/1/27/entrez SP - 9 EP - 13 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 1 N2 - The dicholoromethane extract of Pseudocedrela kotschyi root demonstrated marked antileishmanial properties in preliminary screening of extracts from 21 species commonly used in Malian traditional medicine. Phytochemical investigation of the active extract yielded three novel phragmalin-type limonoid orthoacetates (1-3), named kotschyins A-C, and the known compounds 7-deacetylgedunin (4) and 7-deacetyl-7-oxogedunin (5). The structures of 1-3 were elucidated by analytical methods including 1D- and 2D-NMR spectroscopy together with MS spectroscopy. The relative configurations of 1-3 were assigned on the basis of NOE correlations. The extract and the isolated compounds were tested for their antiprotozoal activities against Leishmania donovani, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, and Plasmodium falciparum as well as for cytotoxicity toward the L-6 cell line. The crude extract and the two gedunin derivatives exhibited good in vitro activity against all of these parasites. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/17253841/Limonoid_orthoacetates_and_antiprotozoal_compounds_from_the_roots_of_Pseudocedrela_kotschyi_ L2 - https://doi.org/10.1021/np0680230 DB - PRIME DP - Unbound Medicine ER -