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Antimicrobial arylcoumarins from Asphodelus microcarpus.
J Nat Prod. 2007 Jan; 70(1):118-20.JN

Abstract

A new aryl coumarin glucoside, asphodelin A 4'-O-beta-d-glucoside (1), and its aglycon, asphodelin A (2), were isolated from Asphodelus microcarpus. The structures were determined by detailed spectroscopic analysis and chemical transformation as 3-(2'-hydroxy-p-O-beta-d-glucopyranosyloxyphenyl)-4,7-dihydroxy-2H-1-benzopyran-2-one (1) and 3-(2',4'-dihydroxyphenyl)-4,7-dihydroxy-2H-1-benzopyran-2-one (2), respectively. These compounds were isolated following bioactivity-directed fractionation, using antimicrobial activity, in which 1 and 2 exhibited moderate and potent activities, respectively. This is the first report of a 3-arylcoumarin derivative, a rare class of isoflavonoids, from a plant in the family Liliaceae.

Authors+Show Affiliations

El-Seedi HR
Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Box 574, S-751 23 Uppsala, Sweden. hesham.el-seedi@fkog.uu.se

MeSH

Anti-Infective AgentsBotrytisCandida albicansCoumarinsEgyptEscherichia coliGlucosidesLiliaceaeMicrobial Sensitivity TestsMolecular StructurePlants, MedicinalPseudomonas aeruginosaStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17253862

Citation

El-Seedi, Hesham R.. "Antimicrobial Arylcoumarins From Asphodelus Microcarpus." Journal of Natural Products, vol. 70, no. 1, 2007, pp. 118-20.
El-Seedi HR. Antimicrobial arylcoumarins from Asphodelus microcarpus. J Nat Prod. 2007;70(1):118-20.
El-Seedi, H. R. (2007). Antimicrobial arylcoumarins from Asphodelus microcarpus. Journal of Natural Products, 70(1), 118-20.
El-Seedi HR. Antimicrobial Arylcoumarins From Asphodelus Microcarpus. J Nat Prod. 2007;70(1):118-20. PubMed PMID: 17253862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial arylcoumarins from Asphodelus microcarpus. A1 - El-Seedi,Hesham R, PY - 2007/1/27/pubmed PY - 2007/3/8/medline PY - 2007/1/27/entrez SP - 118 EP - 20 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 1 N2 - A new aryl coumarin glucoside, asphodelin A 4'-O-beta-d-glucoside (1), and its aglycon, asphodelin A (2), were isolated from Asphodelus microcarpus. The structures were determined by detailed spectroscopic analysis and chemical transformation as 3-(2'-hydroxy-p-O-beta-d-glucopyranosyloxyphenyl)-4,7-dihydroxy-2H-1-benzopyran-2-one (1) and 3-(2',4'-dihydroxyphenyl)-4,7-dihydroxy-2H-1-benzopyran-2-one (2), respectively. These compounds were isolated following bioactivity-directed fractionation, using antimicrobial activity, in which 1 and 2 exhibited moderate and potent activities, respectively. This is the first report of a 3-arylcoumarin derivative, a rare class of isoflavonoids, from a plant in the family Liliaceae. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/17253862/Antimicrobial_arylcoumarins_from_Asphodelus_microcarpus_ L2 - https://doi.org/10.1021/np060444u DB - PRIME DP - Unbound Medicine ER -