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Hodgkin's lymphoma in systemic lupus erythematosus.
Rheumatology (Oxford) 2007; 46(5):830-2R

Abstract

OBJECTIVE

In systemic lupus erythematosus (SLE), there is a well-documented increased risk of non-Hodgkin's lymphoma (NHL), but little is known about the risk of Hodgkin's lymphoma (HL). The purpose of our work was to describe the phenomenon of HL in SLE.

METHODS

A multi-site cohort of 9547 SLE subjects was assembled; HL cases were ascertained through cancer registry linkage, and the standardized incidence ratio (SIR) for HL was determined. We also performed a literature search for HL cases in SLE, and compared these with our sample. Finally, we pooled results from our cohort study with two large population-based cohort studies providing SIR estimates for HL in SLE.

RESULTS

Five cases of HL occurred in our SLE cohort during the observation interval, for an SIR of 2.4 (95% CI 0.8, 5.5). The literature review documented 13 HL case reports developing in patients with SLE. A pooled analysis combining our data with the other large cohort studies yielded a standardized incidence ratio of 3.16 (95% CI, 1.63-5.51) for HL in SLE.

CONCLUSIONS

Data suggest that risk in SLE is increased not only for NHL, but also for other malignancies arising from B-lymphocytes, including HL.

Authors+Show Affiliations

Division of Clinical Epidemiology, Montreal General Hospital, Montreal, QC, Canada. sasha.bernatsky@mail.mcgill.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Review

Language

eng

PubMed ID

17255135

Citation

Bernatsky, S, et al. "Hodgkin's Lymphoma in Systemic Lupus Erythematosus." Rheumatology (Oxford, England), vol. 46, no. 5, 2007, pp. 830-2.
Bernatsky S, Ramsey-Goldman R, Isenberg D, et al. Hodgkin's lymphoma in systemic lupus erythematosus. Rheumatology (Oxford). 2007;46(5):830-2.
Bernatsky, S., Ramsey-Goldman, R., Isenberg, D., Rahman, A., Dooley, M. A., Sibley, J., ... Clarke, A. (2007). Hodgkin's lymphoma in systemic lupus erythematosus. Rheumatology (Oxford, England), 46(5), pp. 830-2.
Bernatsky S, et al. Hodgkin's Lymphoma in Systemic Lupus Erythematosus. Rheumatology (Oxford). 2007;46(5):830-2. PubMed PMID: 17255135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hodgkin's lymphoma in systemic lupus erythematosus. AU - Bernatsky,S, AU - Ramsey-Goldman,R, AU - Isenberg,D, AU - Rahman,A, AU - Dooley,M A, AU - Sibley,J, AU - Boivin,J-F, AU - Joseph,L, AU - Armitage,J, AU - Zoma,A, AU - Clarke,A, Y1 - 2007/01/25/ PY - 2007/1/27/pubmed PY - 2007/7/4/medline PY - 2007/1/27/entrez SP - 830 EP - 2 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 46 IS - 5 N2 - OBJECTIVE: In systemic lupus erythematosus (SLE), there is a well-documented increased risk of non-Hodgkin's lymphoma (NHL), but little is known about the risk of Hodgkin's lymphoma (HL). The purpose of our work was to describe the phenomenon of HL in SLE. METHODS: A multi-site cohort of 9547 SLE subjects was assembled; HL cases were ascertained through cancer registry linkage, and the standardized incidence ratio (SIR) for HL was determined. We also performed a literature search for HL cases in SLE, and compared these with our sample. Finally, we pooled results from our cohort study with two large population-based cohort studies providing SIR estimates for HL in SLE. RESULTS: Five cases of HL occurred in our SLE cohort during the observation interval, for an SIR of 2.4 (95% CI 0.8, 5.5). The literature review documented 13 HL case reports developing in patients with SLE. A pooled analysis combining our data with the other large cohort studies yielded a standardized incidence ratio of 3.16 (95% CI, 1.63-5.51) for HL in SLE. CONCLUSIONS: Data suggest that risk in SLE is increased not only for NHL, but also for other malignancies arising from B-lymphocytes, including HL. SN - 1462-0324 UR - https://www.unboundmedicine.com/medline/citation/17255135/Hodgkin's_lymphoma_in_systemic_lupus_erythematosus_ L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/kel444 DB - PRIME DP - Unbound Medicine ER -