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Risk factors for small bowel bacterial overgrowth in cystic fibrosis.
J Pediatr Gastroenterol Nutr. 2007 Feb; 44(2):212-8.JP

Abstract

OBJECTIVES

The purpose of this study was to determine the prevalence of small bowel bacterial overgrowth in patients with pancreatic-insufficient cystic fibrosis (CF) compared with age-matched controls and to identify potential risk factors for small bowel bacterial overgrowth.

PATIENTS AND METHODS

Fifty patients, 25 pancreatic-insufficient CF study patients (mean age, 17 y) and 25 gastrointestinal clinic control patients (mean age, 15 y), completed a glucose-hydrogen breath test after an overnight fast. Study patients completed a quality-of-life questionnaire modified from the Cystic Fibrosis Questionnaire. The medical history of each patient was compared with breath test results. A positive breath test was defined as a fasting hydrogen > or =15 ppm or a rise of > or =10 ppm hydrogen over baseline during the test.

RESULTS

The prevalence of positive breath tests was higher in the CF study group (56%) than in the control group (20%) (P = 0.02). The mean fasting hydrogen levels of patients in the study and control groups were 22 and 5 ppm (P = 0.0001). The mean questionnaire scores were not significantly different between breath test-positive and -negative study patients. The use of azithromycin was associated with an increased risk of a positive breath test. Use of laxatives and inhaled ipratropium was associated with a decreased risk of a positive breath test.

CONCLUSIONS

Patients with CF were more likely to have elevated fasting hydrogen levels compared with controls. This suggests a high prevalence of small bowel bacterial overgrowth in CF patients. Medications commonly used by CF patients may influence intestinal health.

Authors+Show Affiliations

Division of Gastroenterology, Children's Hospital and Research Center Oakland, Oakland, CA 94609-1809, USA. Jfridge@mail.cho.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17255834

Citation

Fridge, Jacqueline L., et al. "Risk Factors for Small Bowel Bacterial Overgrowth in Cystic Fibrosis." Journal of Pediatric Gastroenterology and Nutrition, vol. 44, no. 2, 2007, pp. 212-8.
Fridge JL, Conrad C, Gerson L, et al. Risk factors for small bowel bacterial overgrowth in cystic fibrosis. J Pediatr Gastroenterol Nutr. 2007;44(2):212-8.
Fridge, J. L., Conrad, C., Gerson, L., Castillo, R. O., & Cox, K. (2007). Risk factors for small bowel bacterial overgrowth in cystic fibrosis. Journal of Pediatric Gastroenterology and Nutrition, 44(2), 212-8.
Fridge JL, et al. Risk Factors for Small Bowel Bacterial Overgrowth in Cystic Fibrosis. J Pediatr Gastroenterol Nutr. 2007;44(2):212-8. PubMed PMID: 17255834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for small bowel bacterial overgrowth in cystic fibrosis. AU - Fridge,Jacqueline L, AU - Conrad,Carol, AU - Gerson,Lauren, AU - Castillo,Ricardo O, AU - Cox,Kenneth, PY - 2007/1/27/pubmed PY - 2007/2/6/medline PY - 2007/1/27/entrez SP - 212 EP - 8 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 44 IS - 2 N2 - OBJECTIVES: The purpose of this study was to determine the prevalence of small bowel bacterial overgrowth in patients with pancreatic-insufficient cystic fibrosis (CF) compared with age-matched controls and to identify potential risk factors for small bowel bacterial overgrowth. PATIENTS AND METHODS: Fifty patients, 25 pancreatic-insufficient CF study patients (mean age, 17 y) and 25 gastrointestinal clinic control patients (mean age, 15 y), completed a glucose-hydrogen breath test after an overnight fast. Study patients completed a quality-of-life questionnaire modified from the Cystic Fibrosis Questionnaire. The medical history of each patient was compared with breath test results. A positive breath test was defined as a fasting hydrogen > or =15 ppm or a rise of > or =10 ppm hydrogen over baseline during the test. RESULTS: The prevalence of positive breath tests was higher in the CF study group (56%) than in the control group (20%) (P = 0.02). The mean fasting hydrogen levels of patients in the study and control groups were 22 and 5 ppm (P = 0.0001). The mean questionnaire scores were not significantly different between breath test-positive and -negative study patients. The use of azithromycin was associated with an increased risk of a positive breath test. Use of laxatives and inhaled ipratropium was associated with a decreased risk of a positive breath test. CONCLUSIONS: Patients with CF were more likely to have elevated fasting hydrogen levels compared with controls. This suggests a high prevalence of small bowel bacterial overgrowth in CF patients. Medications commonly used by CF patients may influence intestinal health. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/17255834/Risk_factors_for_small_bowel_bacterial_overgrowth_in_cystic_fibrosis_ L2 - http://dx.doi.org/10.1097/MPG.0b013e31802c0ceb DB - PRIME DP - Unbound Medicine ER -