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Pigmentation after single and multiple UV-exposures depending on UV-spectrum.
Arch Dermatol Res. 2007 Apr; 299(1):25-32.AD

Abstract

Minimal pigmentation dose (MMD) after a single UV-exposure is well investigated. Whereas only few studies have established MMD after multiple UV-exposures and mainly in fair-skinned persons. The purpose of this study was to establish MMD 1 week after, respectively, one and five UV-exposures in volunteers with a large variation in constitutive pigmentation. A total of 52 volunteers (skin Types II-V) had skin pigmentation quantified by reflectance spectroscopy. They were UV-exposed on the back for 1 and 5 days using a Solar Simulator, narrowband UVB, broadband UVA and UVA1. For all sources a higher dose was needed the more pigmented the skin, except for UVA1. After one UV-exposure, we found a significant positive linear correlation between UV-dose to one MMD, skin type and pre-exposure skin pigmentation. After five UV-exposures the positive linear correlation between UV-dose and MMD and skin type was only significant for narrow band UVB, pre-exposure skin pigmentation was significant also for Solar Simulator. For UVA and particularly UVA1 the MMD was independent of pre-exposure pigmentation. The number of SED to MMD is therefore almost the same for very fair-skinned and dark-skinned persons. Pre-exposure pigmentation was clearly more predictive of MMD than skin type. 50% of MMD equals a pigmentation increase of 1%. The shorter the wavelengths the higher the SED to produce MMD. Solar was the least melanogenic and UVA1 the most melanogenic. For the UVB-sources a higher dose was needed the more pigmented the skin. For UVA the MMD was independent of pre-exposure pigmentation.

Authors+Show Affiliations

Department of Dermatology, D92, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark. mette@ravnbak.dkNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17256147

Citation

Ravnbak, M H., and H C. Wulf. "Pigmentation After Single and Multiple UV-exposures Depending On UV-spectrum." Archives of Dermatological Research, vol. 299, no. 1, 2007, pp. 25-32.
Ravnbak MH, Wulf HC. Pigmentation after single and multiple UV-exposures depending on UV-spectrum. Arch Dermatol Res. 2007;299(1):25-32.
Ravnbak, M. H., & Wulf, H. C. (2007). Pigmentation after single and multiple UV-exposures depending on UV-spectrum. Archives of Dermatological Research, 299(1), 25-32.
Ravnbak MH, Wulf HC. Pigmentation After Single and Multiple UV-exposures Depending On UV-spectrum. Arch Dermatol Res. 2007;299(1):25-32. PubMed PMID: 17256147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pigmentation after single and multiple UV-exposures depending on UV-spectrum. AU - Ravnbak,M H, AU - Wulf,H C, Y1 - 2007/01/26/ PY - 2006/02/01/received PY - 2006/12/08/accepted PY - 2006/12/07/revised PY - 2007/1/27/pubmed PY - 2007/7/19/medline PY - 2007/1/27/entrez SP - 25 EP - 32 JF - Archives of dermatological research JO - Arch Dermatol Res VL - 299 IS - 1 N2 - Minimal pigmentation dose (MMD) after a single UV-exposure is well investigated. Whereas only few studies have established MMD after multiple UV-exposures and mainly in fair-skinned persons. The purpose of this study was to establish MMD 1 week after, respectively, one and five UV-exposures in volunteers with a large variation in constitutive pigmentation. A total of 52 volunteers (skin Types II-V) had skin pigmentation quantified by reflectance spectroscopy. They were UV-exposed on the back for 1 and 5 days using a Solar Simulator, narrowband UVB, broadband UVA and UVA1. For all sources a higher dose was needed the more pigmented the skin, except for UVA1. After one UV-exposure, we found a significant positive linear correlation between UV-dose to one MMD, skin type and pre-exposure skin pigmentation. After five UV-exposures the positive linear correlation between UV-dose and MMD and skin type was only significant for narrow band UVB, pre-exposure skin pigmentation was significant also for Solar Simulator. For UVA and particularly UVA1 the MMD was independent of pre-exposure pigmentation. The number of SED to MMD is therefore almost the same for very fair-skinned and dark-skinned persons. Pre-exposure pigmentation was clearly more predictive of MMD than skin type. 50% of MMD equals a pigmentation increase of 1%. The shorter the wavelengths the higher the SED to produce MMD. Solar was the least melanogenic and UVA1 the most melanogenic. For the UVB-sources a higher dose was needed the more pigmented the skin. For UVA the MMD was independent of pre-exposure pigmentation. SN - 0340-3696 UR - https://www.unboundmedicine.com/medline/citation/17256147/Pigmentation_after_single_and_multiple_UV_exposures_depending_on_UV_spectrum_ L2 - https://link.springer.com/article/10.1007/s00403-006-0728-3 DB - PRIME DP - Unbound Medicine ER -