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Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis.
J Clin Periodontol. 2007 Apr; 34(4):278-84.JC

Abstract

AIM

Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) have important roles in proteolytic events in periodontitis. The aim of this study was to investigate TPA and PAI-1 gene polymorphisms in relation to susceptibility to generalized aggressive periodontitis (G-AgP).

METHODS

Genomic DNA was obtained from peripheral blood of 90 G-AgP patients and 154 periodontally healthy subjects. 4G/5G polymorphism in the promoter region of the PAI-1 gene and Alu-repeat insertion/deletion (I/D) polymorphism in intron 8 of the TPA gene were genotyped by polymerase chain reaction and endonuclease digestion.

RESULTS

The genotype distributions of TPA and PAI-1 genes were similar between G-AgP and healthy subjects (p>0.05). The distribution of TPA genotypes in G-AgP patients was 33.4% D/D, 44.4% I/D, and 22.2% I/I and was 26.3% D/D, 40.4% I/D, and 33.3% I/I in healthy subjects. The D allele was 55.6% in G-AgP and 46.6% in healthy subjects. There was a significant difference among study groups in D allele frequencies (p=0.044). The PAI-1 genotype distribution in G-AgP was 29.1% 4G/4G, 43.0% 4G/5G, and 27.9% 5G/5G, while it was 35.7% 4G/4G, 43.8% 4G/5G, and 20.5% 5G/5G in healthy subjects.

CONCLUSION

These data suggest that the D polymorphic allele of TPA gene polymorphism could be associated with susceptibility to G-AgP in Turkish subjects.

Authors+Show Affiliations

Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey. gemingil@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17257155

Citation

Emingil, Gülnur, et al. "Gene Polymorphisms of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Turkish Patients With Generalized Aggressive Periodontitis." Journal of Clinical Periodontology, vol. 34, no. 4, 2007, pp. 278-84.
Emingil G, Berdeli A, Gürkan A, et al. Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis. J Clin Periodontol. 2007;34(4):278-84.
Emingil, G., Berdeli, A., Gürkan, A., Han Saygan, B., Köse, T., & Atilla, G. (2007). Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis. Journal of Clinical Periodontology, 34(4), 278-84.
Emingil G, et al. Gene Polymorphisms of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Turkish Patients With Generalized Aggressive Periodontitis. J Clin Periodontol. 2007;34(4):278-84. PubMed PMID: 17257155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis. AU - Emingil,Gülnur, AU - Berdeli,Afig, AU - Gürkan,Ali, AU - Han Saygan,Buket, AU - Köse,Timur, AU - Atilla,Gül, Y1 - 2007/01/25/ PY - 2007/1/30/pubmed PY - 2007/5/15/medline PY - 2007/1/30/entrez SP - 278 EP - 84 JF - Journal of clinical periodontology JO - J Clin Periodontol VL - 34 IS - 4 N2 - AIM: Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) have important roles in proteolytic events in periodontitis. The aim of this study was to investigate TPA and PAI-1 gene polymorphisms in relation to susceptibility to generalized aggressive periodontitis (G-AgP). METHODS: Genomic DNA was obtained from peripheral blood of 90 G-AgP patients and 154 periodontally healthy subjects. 4G/5G polymorphism in the promoter region of the PAI-1 gene and Alu-repeat insertion/deletion (I/D) polymorphism in intron 8 of the TPA gene were genotyped by polymerase chain reaction and endonuclease digestion. RESULTS: The genotype distributions of TPA and PAI-1 genes were similar between G-AgP and healthy subjects (p>0.05). The distribution of TPA genotypes in G-AgP patients was 33.4% D/D, 44.4% I/D, and 22.2% I/I and was 26.3% D/D, 40.4% I/D, and 33.3% I/I in healthy subjects. The D allele was 55.6% in G-AgP and 46.6% in healthy subjects. There was a significant difference among study groups in D allele frequencies (p=0.044). The PAI-1 genotype distribution in G-AgP was 29.1% 4G/4G, 43.0% 4G/5G, and 27.9% 5G/5G, while it was 35.7% 4G/4G, 43.8% 4G/5G, and 20.5% 5G/5G in healthy subjects. CONCLUSION: These data suggest that the D polymorphic allele of TPA gene polymorphism could be associated with susceptibility to G-AgP in Turkish subjects. SN - 0303-6979 UR - https://www.unboundmedicine.com/medline/citation/17257155/Gene_polymorphisms_of_tissue_plasminogen_activator_and_plasminogen_activator_inhibitor_1_in_Turkish_patients_with_generalized_aggressive_periodontitis_ DB - PRIME DP - Unbound Medicine ER -