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Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990-2000.
Diabet Med. 2007 Feb; 24(2):200-7.DM

Abstract

AIM

To determine the incidence of Type 2 diabetes and to examine the effect of different cut-points for impaired fasting glucose (IFG) on diabetes incidence.

METHODS

Population-based longitudinal study (1990-2000) with clinical, anthropometric and biochemical measurements, including an oral glucose tolerance test (OGTT), in 1040 non-diabetic adults aged 40-69 years at baseline. Baseline glucose status was defined as normoglycaemia < 5.6, IFG-lower 5.6-6.0 and IFG-original 6.1-6.9 mmol/l. The all-IFG group included fasting glucose values of 5.6-6.9 mmol/l.

RESULTS

The 10-year cumulative incidence of diabetes was 7.3 per 1000 person-years. Diabetes incidence was 2.4 [95% confidence interval (CI) 1.2, 4.8], 6.2 (4.0, 9.8) and 17.5 (12.5, 24.5) per 1000 person-years in those with normoglycaemia, IFG-lower and IFG-original, respectively. Compared with normoglycaemia, the age/sex-adjusted risk [hazard ratio (HR) and 95% CI] for incident diabetes was greatest in the IFG-original category (HR 6.9; 3.1, 15.2) and increased to a lesser degree in the IFG-lower (HR 2.5; 1.1, 5.7) and all-IFG categories (HR 4.1; 1.9, 8.7). When adjusted for confounding factors, the magnitude and direction of associations persisted, with HR 1.9, 4.4 and 2.9, for the categories IFG-lower, IFG-original and all-IFG, respectively.

CONCLUSIONS

Diabetes incidence is more strongly related to IFG defined as fasting glucose between 6.1 and 6.9 mmol/l than to the lower category of 5.6-6.0 mmol/l, or entire range of 5.6-6.9 mmol/l. Future studies should examine the association of IFG with cardiovascular outcomes, but for diabetes risk our study supports the use of the IFG cut-point at 6.1 mmol/l.

Authors+Show Affiliations

Medical Research Council Epidemiology Unit, Elsie Widdowson Laboratories, Cambridge, UK. nita.forouhi@mrc-epid.cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17257284

Citation

Forouhi, N G., et al. "Incidence of Type 2 Diabetes in England and Its Association With Baseline Impaired Fasting Glucose: the Ely Study 1990-2000." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 24, no. 2, 2007, pp. 200-7.
Forouhi NG, Luan J, Hennings S, et al. Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990-2000. Diabet Med. 2007;24(2):200-7.
Forouhi, N. G., Luan, J., Hennings, S., & Wareham, N. J. (2007). Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990-2000. Diabetic Medicine : a Journal of the British Diabetic Association, 24(2), 200-7.
Forouhi NG, et al. Incidence of Type 2 Diabetes in England and Its Association With Baseline Impaired Fasting Glucose: the Ely Study 1990-2000. Diabet Med. 2007;24(2):200-7. PubMed PMID: 17257284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990-2000. AU - Forouhi,N G, AU - Luan,J, AU - Hennings,S, AU - Wareham,N J, PY - 2007/1/30/pubmed PY - 2007/6/30/medline PY - 2007/1/30/entrez SP - 200 EP - 7 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 24 IS - 2 N2 - AIM: To determine the incidence of Type 2 diabetes and to examine the effect of different cut-points for impaired fasting glucose (IFG) on diabetes incidence. METHODS: Population-based longitudinal study (1990-2000) with clinical, anthropometric and biochemical measurements, including an oral glucose tolerance test (OGTT), in 1040 non-diabetic adults aged 40-69 years at baseline. Baseline glucose status was defined as normoglycaemia < 5.6, IFG-lower 5.6-6.0 and IFG-original 6.1-6.9 mmol/l. The all-IFG group included fasting glucose values of 5.6-6.9 mmol/l. RESULTS: The 10-year cumulative incidence of diabetes was 7.3 per 1000 person-years. Diabetes incidence was 2.4 [95% confidence interval (CI) 1.2, 4.8], 6.2 (4.0, 9.8) and 17.5 (12.5, 24.5) per 1000 person-years in those with normoglycaemia, IFG-lower and IFG-original, respectively. Compared with normoglycaemia, the age/sex-adjusted risk [hazard ratio (HR) and 95% CI] for incident diabetes was greatest in the IFG-original category (HR 6.9; 3.1, 15.2) and increased to a lesser degree in the IFG-lower (HR 2.5; 1.1, 5.7) and all-IFG categories (HR 4.1; 1.9, 8.7). When adjusted for confounding factors, the magnitude and direction of associations persisted, with HR 1.9, 4.4 and 2.9, for the categories IFG-lower, IFG-original and all-IFG, respectively. CONCLUSIONS: Diabetes incidence is more strongly related to IFG defined as fasting glucose between 6.1 and 6.9 mmol/l than to the lower category of 5.6-6.0 mmol/l, or entire range of 5.6-6.9 mmol/l. Future studies should examine the association of IFG with cardiovascular outcomes, but for diabetes risk our study supports the use of the IFG cut-point at 6.1 mmol/l. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/17257284/Incidence_of_Type_2_diabetes_in_England_and_its_association_with_baseline_impaired_fasting_glucose:_the_Ely_study_1990_2000_ L2 - https://doi.org/10.1111/j.1464-5491.2007.02068.x DB - PRIME DP - Unbound Medicine ER -