Tags

Type your tag names separated by a space and hit enter

Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection.
Curr Med Res Opin 2006; 22(12):2411-8CM

Abstract

OBJECTIVE

This study compared the efficacy of 1000 mg of paracetamol combined with 60 mg of pseudoephedrine, with that of either paracetamol or pseudoephedrine alone and placebo for the treatment of symptomatic URTI.

RESEARCH DESIGN AND METHODS

A double-blind, parallel group study was performed on 305 patients with URTI (nasal airflow resistance [NAR] of > 0.25 Pa cm3 s and a global pain score of at least moderate intensity). NAR and pain relief/intensity scores were measured over 4 h after initial dose. Patients then dosed up to three times daily for 3 days and recorded nasal congestion and pain intensity scores.

MAIN OUTCOME MEASURES

Nasal airflow conductance (NAC) and pain relief after the initial dose were primary objectives. NAC was calculated from NAR. Pain relief was measured on a 5-point verbal rating scale (VRS) and pain intensity and nasal congestion on a 4-point VRS. Data were analysed using analysis of covariance. Safety was assessed by adverse events.

RESULTS

A single dose of the combination was superior to paracetamol and placebo for NAC (p = 0.0001) and was superior to pseudoephedrine and placebo for pain relief (p < or = 0.048). Multiple doses of the combination were also superior to paracetamol and placebo for decongestion (p < or = 0.021) and were superior to pseudoephedrine and placebo for pain reduction (p < or = 0.0057). All treatments were well tolerated.

CONCLUSIONS

The combination treatment provided a greater decongestant effect than either paracetamol or placebo and better pain relief than either pseudoephedrine or placebo. The additive effect of the combination was apparent for both single and multiple doses.

Authors+Show Affiliations

Common Cold Centre, Cardiff University, Cardiff, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17257455

Citation

Eccles, R, et al. "Efficacy of a Paracetamol-pseudoephedrine Combination for Treatment of Nasal Congestion and Pain-related Symptoms in Upper Respiratory Tract Infection." Current Medical Research and Opinion, vol. 22, no. 12, 2006, pp. 2411-8.
Eccles R, Jawad M, Jawad S, et al. Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection. Curr Med Res Opin. 2006;22(12):2411-8.
Eccles, R., Jawad, M., Jawad, S., Ridge, D., North, M., Jones, E., & Burnett, I. (2006). Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection. Current Medical Research and Opinion, 22(12), pp. 2411-8.
Eccles R, et al. Efficacy of a Paracetamol-pseudoephedrine Combination for Treatment of Nasal Congestion and Pain-related Symptoms in Upper Respiratory Tract Infection. Curr Med Res Opin. 2006;22(12):2411-8. PubMed PMID: 17257455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection. AU - Eccles,R, AU - Jawad,M, AU - Jawad,S, AU - Ridge,D, AU - North,M, AU - Jones,E, AU - Burnett,I, PY - 2007/1/30/pubmed PY - 2007/3/14/medline PY - 2007/1/30/entrez SP - 2411 EP - 8 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 22 IS - 12 N2 - OBJECTIVE: This study compared the efficacy of 1000 mg of paracetamol combined with 60 mg of pseudoephedrine, with that of either paracetamol or pseudoephedrine alone and placebo for the treatment of symptomatic URTI. RESEARCH DESIGN AND METHODS: A double-blind, parallel group study was performed on 305 patients with URTI (nasal airflow resistance [NAR] of > 0.25 Pa cm3 s and a global pain score of at least moderate intensity). NAR and pain relief/intensity scores were measured over 4 h after initial dose. Patients then dosed up to three times daily for 3 days and recorded nasal congestion and pain intensity scores. MAIN OUTCOME MEASURES: Nasal airflow conductance (NAC) and pain relief after the initial dose were primary objectives. NAC was calculated from NAR. Pain relief was measured on a 5-point verbal rating scale (VRS) and pain intensity and nasal congestion on a 4-point VRS. Data were analysed using analysis of covariance. Safety was assessed by adverse events. RESULTS: A single dose of the combination was superior to paracetamol and placebo for NAC (p = 0.0001) and was superior to pseudoephedrine and placebo for pain relief (p < or = 0.048). Multiple doses of the combination were also superior to paracetamol and placebo for decongestion (p < or = 0.021) and were superior to pseudoephedrine and placebo for pain reduction (p < or = 0.0057). All treatments were well tolerated. CONCLUSIONS: The combination treatment provided a greater decongestant effect than either paracetamol or placebo and better pain relief than either pseudoephedrine or placebo. The additive effect of the combination was apparent for both single and multiple doses. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/17257455/Efficacy_of_a_paracetamol_pseudoephedrine_combination_for_treatment_of_nasal_congestion_and_pain_related_symptoms_in_upper_respiratory_tract_infection_ L2 - http://www.tandfonline.com/doi/full/10.1185/030079906X154105 DB - PRIME DP - Unbound Medicine ER -