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Intake and adipose tissue composition of fatty acids and risk of myocardial infarction in a male Portuguese community sample.
J Am Diet Assoc 2007; 107(2):276-86JA

Abstract

OBJECTIVE

To evaluate the relation between intake and adipose tissue composition of fatty acids and acute myocardial infarction in Portuguese men.

DESIGN

Case-control study. Diet was assessed using a semiquantitative food frequency questionnaire. In 49 case and 49 control subjects, adipose tissue composition was assessed by gas-liquid chromatography.

SUBJECTS/SETTING

Population-based; subjects were 297 consecutively admitted cases of first acute myocardial infarction in a tertiary care hospital who were aged>or=40 years. Three hundred ten community controls were selected by random-digit dialing.

MAIN OUTCOME MEASURE

Odds ratio (OR).

STATISTICAL ANALYSIS PERFORMED

Logistic regression, adjusting for age, education, family history of acute myocardial infarction, smoking, physical activity, body mass index, and energy intake.

RESULTS

Total fat intake (OR 0.45, fourth quartile, P=0.02), lauric acid (OR 0.44, fourth quartile, P=0.02), palmitic acid (OR 0.58, fourth quartile, P=0.03), and oleic acid (OR 0.42, fourth quartile, P=0.03) were inversely associated with acute myocardial infarction. No significant effects were found for the remaining fatty acids. In the adipose tissue composition data, the adjusted risk estimates of acute myocardial infarction for the highest vs the lowest tertile were 0.16, 0.14, and 0.04 for lauric, oleic, and trans-fatty acids, respectively. A significant direct association was found for palmitic and linoleic acids (adjusted ORs for the highest tertile were 9.02 and 3.63, respectively).

CONCLUSIONS

Low intake of total fat and lauric acid from dairy products was associated with acute myocardial infarction. The association of polyunsaturated fatty acids with risk of acute myocardial infarction was nonsignificant after adjustment for energy intake and confounders. Recommendations on fatty acid intake should aim for both an upper and lower limit.

Authors+Show Affiliations

Department of Epidemiology, University of Porto Medical School, Portugal.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17258965

Citation

Lopes, Carla, et al. "Intake and Adipose Tissue Composition of Fatty Acids and Risk of Myocardial Infarction in a Male Portuguese Community Sample." Journal of the American Dietetic Association, vol. 107, no. 2, 2007, pp. 276-86.
Lopes C, Aro A, Azevedo A, et al. Intake and adipose tissue composition of fatty acids and risk of myocardial infarction in a male Portuguese community sample. J Am Diet Assoc. 2007;107(2):276-86.
Lopes, C., Aro, A., Azevedo, A., Ramos, E., & Barros, H. (2007). Intake and adipose tissue composition of fatty acids and risk of myocardial infarction in a male Portuguese community sample. Journal of the American Dietetic Association, 107(2), pp. 276-86.
Lopes C, et al. Intake and Adipose Tissue Composition of Fatty Acids and Risk of Myocardial Infarction in a Male Portuguese Community Sample. J Am Diet Assoc. 2007;107(2):276-86. PubMed PMID: 17258965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake and adipose tissue composition of fatty acids and risk of myocardial infarction in a male Portuguese community sample. AU - Lopes,Carla, AU - Aro,Antti, AU - Azevedo,Ana, AU - Ramos,Elisabete, AU - Barros,Henrique, PY - 2006/04/03/received PY - 2007/1/30/pubmed PY - 2007/3/8/medline PY - 2007/1/30/entrez SP - 276 EP - 86 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 107 IS - 2 N2 - OBJECTIVE: To evaluate the relation between intake and adipose tissue composition of fatty acids and acute myocardial infarction in Portuguese men. DESIGN: Case-control study. Diet was assessed using a semiquantitative food frequency questionnaire. In 49 case and 49 control subjects, adipose tissue composition was assessed by gas-liquid chromatography. SUBJECTS/SETTING: Population-based; subjects were 297 consecutively admitted cases of first acute myocardial infarction in a tertiary care hospital who were aged>or=40 years. Three hundred ten community controls were selected by random-digit dialing. MAIN OUTCOME MEASURE: Odds ratio (OR). STATISTICAL ANALYSIS PERFORMED: Logistic regression, adjusting for age, education, family history of acute myocardial infarction, smoking, physical activity, body mass index, and energy intake. RESULTS: Total fat intake (OR 0.45, fourth quartile, P=0.02), lauric acid (OR 0.44, fourth quartile, P=0.02), palmitic acid (OR 0.58, fourth quartile, P=0.03), and oleic acid (OR 0.42, fourth quartile, P=0.03) were inversely associated with acute myocardial infarction. No significant effects were found for the remaining fatty acids. In the adipose tissue composition data, the adjusted risk estimates of acute myocardial infarction for the highest vs the lowest tertile were 0.16, 0.14, and 0.04 for lauric, oleic, and trans-fatty acids, respectively. A significant direct association was found for palmitic and linoleic acids (adjusted ORs for the highest tertile were 9.02 and 3.63, respectively). CONCLUSIONS: Low intake of total fat and lauric acid from dairy products was associated with acute myocardial infarction. The association of polyunsaturated fatty acids with risk of acute myocardial infarction was nonsignificant after adjustment for energy intake and confounders. Recommendations on fatty acid intake should aim for both an upper and lower limit. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/17258965/Intake_and_adipose_tissue_composition_of_fatty_acids_and_risk_of_myocardial_infarction_in_a_male_Portuguese_community_sample_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(06)02496-5 DB - PRIME DP - Unbound Medicine ER -