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Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance: the Atherosclerosis Risk in Communities Study.
Diabetes Care. 2007 Feb; 30(2):325-31.DC

Abstract

OBJECTIVE

We compared and contrasted cardiovascular disease (CVD) risk factors, subclinical manifestations of CVD, incident coronary heart disease (CHD), and all-cause mortality by categories of impaired glucose regulation in nondiabetic individuals.

RESEARCH DESIGN AND METHODS

The study included 6,888 participants aged 52-75 years who had no history of diabetes or CVD. All-cause mortality and incident CHD were ascertained over a median of 6.3 years of follow-up.

RESULTS

Agreement between fasting and postchallenge glucose impairment was poor: 3,048 subjects (44%) had neither impaired fasting glucose (IFG) nor impaired glucose tolerance (IGT), 1,690 (25%) had isolated IFG, 1,000 (14%) had isolated IGT, and 1,149 (17%) had both IFG and IGT. After adjustment for age, sex, race, and center, subjects with isolated IFG were more likely to smoke, consume alcohol, and had higher mean BMI, waist circumference, LDL cholesterol, and fasting insulin and lower HDL cholesterol than those with isolated IGT, while subjects with isolated IGT had higher mean triglycerides, systolic blood pressure, and white cell counts. Measures of subclinical CVD and rates of all-cause mortality and incident CHD were similar in isolated IFG and isolated IGT.

CONCLUSIONS

Neither isolated IFG nor isolated IGT was associated with a more adverse CVD risk profile.

Authors+Show Affiliations

Division of EpidemiologyCommunity Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA. pankow@epi.umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17259502

Citation

Pankow, James S., et al. "Cardiometabolic Risk in Impaired Fasting Glucose and Impaired Glucose Tolerance: the Atherosclerosis Risk in Communities Study." Diabetes Care, vol. 30, no. 2, 2007, pp. 325-31.
Pankow JS, Kwan DK, Duncan BB, et al. Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance: the Atherosclerosis Risk in Communities Study. Diabetes Care. 2007;30(2):325-31.
Pankow, J. S., Kwan, D. K., Duncan, B. B., Schmidt, M. I., Couper, D. J., Golden, S., & Ballantyne, C. M. (2007). Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance: the Atherosclerosis Risk in Communities Study. Diabetes Care, 30(2), 325-31.
Pankow JS, et al. Cardiometabolic Risk in Impaired Fasting Glucose and Impaired Glucose Tolerance: the Atherosclerosis Risk in Communities Study. Diabetes Care. 2007;30(2):325-31. PubMed PMID: 17259502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance: the Atherosclerosis Risk in Communities Study. AU - Pankow,James S, AU - Kwan,David K, AU - Duncan,Bruce B, AU - Schmidt,Maria I, AU - Couper,David J, AU - Golden,Sherita, AU - Ballantyne,Christie M, PY - 2007/1/30/pubmed PY - 2007/6/15/medline PY - 2007/1/30/entrez SP - 325 EP - 31 JF - Diabetes care JO - Diabetes Care VL - 30 IS - 2 N2 - OBJECTIVE: We compared and contrasted cardiovascular disease (CVD) risk factors, subclinical manifestations of CVD, incident coronary heart disease (CHD), and all-cause mortality by categories of impaired glucose regulation in nondiabetic individuals. RESEARCH DESIGN AND METHODS: The study included 6,888 participants aged 52-75 years who had no history of diabetes or CVD. All-cause mortality and incident CHD were ascertained over a median of 6.3 years of follow-up. RESULTS: Agreement between fasting and postchallenge glucose impairment was poor: 3,048 subjects (44%) had neither impaired fasting glucose (IFG) nor impaired glucose tolerance (IGT), 1,690 (25%) had isolated IFG, 1,000 (14%) had isolated IGT, and 1,149 (17%) had both IFG and IGT. After adjustment for age, sex, race, and center, subjects with isolated IFG were more likely to smoke, consume alcohol, and had higher mean BMI, waist circumference, LDL cholesterol, and fasting insulin and lower HDL cholesterol than those with isolated IGT, while subjects with isolated IGT had higher mean triglycerides, systolic blood pressure, and white cell counts. Measures of subclinical CVD and rates of all-cause mortality and incident CHD were similar in isolated IFG and isolated IGT. CONCLUSIONS: Neither isolated IFG nor isolated IGT was associated with a more adverse CVD risk profile. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/17259502/Cardiometabolic_risk_in_impaired_fasting_glucose_and_impaired_glucose_tolerance:_the_Atherosclerosis_Risk_in_Communities_Study_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=17259502 DB - PRIME DP - Unbound Medicine ER -