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Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer.
Carcinogenesis 2007; 28(6):1247-53C

Abstract

NOS3 and MPO genes encode endothelial nitric oxide synthase and myeloperoxidase (MPO), respectively, which generate nitric oxide and reactive oxygen species. Because cigarette smoking generates reactive species, we hypothesized that NOS3 and MPO polymorphisms could influence susceptibility to breast cancer, particularly among smokers. We examined the associations between NOS3 Glu298Asp and MPO G-463A polymorphisms and breast cancer risk by cigarette smoking among post-menopausal women in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. Included in this analysis were 502 women who provided blood samples and were diagnosed with breast cancer between 1992 and 2001 and 505 cancer-free controls who were matched to the cases by age, race/ethnicity and date of blood donation. Genotyping for NOS3 and MPO was performed using TaqMan, and unconditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs). No statistically significant relationships were found between NOS3 and MPO genotypes and breast cancer risk. When considering smoking, variant NOS3 genotypes (GT and TT) were significantly associated with reduced breast cancer risk among never smokers (OR = 0.67, 95% CI = 0.45-0.99), but were associated with higher risk among ever smokers (OR = 1.59, 95% CI = 1.05-2.41) and 2-fold increase in risk for those who smoked >10 cigarettes per day (OR = 2.19, 95% CI = 1.21-3.97). NOS3 genotypes appeared to be associated with risk of post-menopausal breast cancer among smokers, supporting the hypothesis that subgroups of women based upon genetic profiles may be at higher risk of breast cancer when exposed to tobacco smoke.

Authors+Show Affiliations

Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. jun.yang@vdh.virginia.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17259657

Citation

Yang, Jun, et al. "Relationships Between Polymorphisms in NOS3 and MPO Genes, Cigarette Smoking and Risk of Post-menopausal Breast Cancer." Carcinogenesis, vol. 28, no. 6, 2007, pp. 1247-53.
Yang J, Ambrosone CB, Hong CC, et al. Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer. Carcinogenesis. 2007;28(6):1247-53.
Yang, J., Ambrosone, C. B., Hong, C. C., Ahn, J., Rodriguez, C., Thun, M. J., & Calle, E. E. (2007). Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer. Carcinogenesis, 28(6), pp. 1247-53.
Yang J, et al. Relationships Between Polymorphisms in NOS3 and MPO Genes, Cigarette Smoking and Risk of Post-menopausal Breast Cancer. Carcinogenesis. 2007;28(6):1247-53. PubMed PMID: 17259657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer. AU - Yang,Jun, AU - Ambrosone,Christine B, AU - Hong,Chi-Chen, AU - Ahn,Jiyoung, AU - Rodriguez,Carmen, AU - Thun,Michael J, AU - Calle,Eugenia E, Y1 - 2007/01/27/ PY - 2007/1/30/pubmed PY - 2007/8/8/medline PY - 2007/1/30/entrez SP - 1247 EP - 53 JF - Carcinogenesis JO - Carcinogenesis VL - 28 IS - 6 N2 - NOS3 and MPO genes encode endothelial nitric oxide synthase and myeloperoxidase (MPO), respectively, which generate nitric oxide and reactive oxygen species. Because cigarette smoking generates reactive species, we hypothesized that NOS3 and MPO polymorphisms could influence susceptibility to breast cancer, particularly among smokers. We examined the associations between NOS3 Glu298Asp and MPO G-463A polymorphisms and breast cancer risk by cigarette smoking among post-menopausal women in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. Included in this analysis were 502 women who provided blood samples and were diagnosed with breast cancer between 1992 and 2001 and 505 cancer-free controls who were matched to the cases by age, race/ethnicity and date of blood donation. Genotyping for NOS3 and MPO was performed using TaqMan, and unconditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs). No statistically significant relationships were found between NOS3 and MPO genotypes and breast cancer risk. When considering smoking, variant NOS3 genotypes (GT and TT) were significantly associated with reduced breast cancer risk among never smokers (OR = 0.67, 95% CI = 0.45-0.99), but were associated with higher risk among ever smokers (OR = 1.59, 95% CI = 1.05-2.41) and 2-fold increase in risk for those who smoked >10 cigarettes per day (OR = 2.19, 95% CI = 1.21-3.97). NOS3 genotypes appeared to be associated with risk of post-menopausal breast cancer among smokers, supporting the hypothesis that subgroups of women based upon genetic profiles may be at higher risk of breast cancer when exposed to tobacco smoke. SN - 0143-3334 UR - https://www.unboundmedicine.com/medline/citation/17259657/Relationships_between_polymorphisms_in_NOS3_and_MPO_genes_cigarette_smoking_and_risk_of_post_menopausal_breast_cancer_ L2 - https://academic.oup.com/carcin/article-lookup/doi/10.1093/carcin/bgm016 DB - PRIME DP - Unbound Medicine ER -