Tags

Type your tag names separated by a space and hit enter

Prevention and treatment of dementia or Alzheimer's disease by statins: a meta-analysis.
Dement Geriatr Cogn Disord 2007; 23(3):194-201DG

Abstract

BACKGROUND/AIM

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are thought to reduce the amount of Abeta peptides by reducing cholesterol from blood and/or cerebrospinal fluid. We performed this meta-analysis to evaluate the preventive and treatment effects of statins on dementia and Alzheimer disease onset.

METHODS

Relevant studies were systematically identified, and data were abstracted according to predefined criteria. We used a fixed-effects model and a random-effects model to compute pooled relative risks and to assess statistical heterogeneity.

RESULTS

The pooled crude odds ratios in statin users as compared with nonusers were 0.67 (95% confidence interval CI 0.54-0.82) in the dementia group and 0.81 (95% CI 0.64-1.02) in the Alzheimer group. The pooled adjusted relative risks calculated by random-effects model were 0.77 (95% CI 0.45-1.30) in the dementia group and 0.81 (95% CI 0.56-1.16) in the Alzheimer group.

CONCLUSIONS

Statin use did not show a beneficial effect on the risk of dementia or Alzheimer's disease. Further study and independent confirmation of the association between statin use and dementia and Alzheimer's disease in larger clinical trials are warranted.

Authors+Show Affiliations

Division of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Kyoto, Japan. zhoubbin@kuhp.kyoto-u.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

17259710

Citation

Zhou, Bin, et al. "Prevention and Treatment of Dementia or Alzheimer's Disease By Statins: a Meta-analysis." Dementia and Geriatric Cognitive Disorders, vol. 23, no. 3, 2007, pp. 194-201.
Zhou B, Teramukai S, Fukushima M. Prevention and treatment of dementia or Alzheimer's disease by statins: a meta-analysis. Dement Geriatr Cogn Disord. 2007;23(3):194-201.
Zhou, B., Teramukai, S., & Fukushima, M. (2007). Prevention and treatment of dementia or Alzheimer's disease by statins: a meta-analysis. Dementia and Geriatric Cognitive Disorders, 23(3), pp. 194-201.
Zhou B, Teramukai S, Fukushima M. Prevention and Treatment of Dementia or Alzheimer's Disease By Statins: a Meta-analysis. Dement Geriatr Cogn Disord. 2007;23(3):194-201. PubMed PMID: 17259710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention and treatment of dementia or Alzheimer's disease by statins: a meta-analysis. AU - Zhou,Bin, AU - Teramukai,Satoshi, AU - Fukushima,Masanori, Y1 - 2007/01/25/ PY - 2006/11/25/accepted PY - 2007/1/30/pubmed PY - 2007/4/27/medline PY - 2007/1/30/entrez SP - 194 EP - 201 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 23 IS - 3 N2 - BACKGROUND/AIM: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are thought to reduce the amount of Abeta peptides by reducing cholesterol from blood and/or cerebrospinal fluid. We performed this meta-analysis to evaluate the preventive and treatment effects of statins on dementia and Alzheimer disease onset. METHODS: Relevant studies were systematically identified, and data were abstracted according to predefined criteria. We used a fixed-effects model and a random-effects model to compute pooled relative risks and to assess statistical heterogeneity. RESULTS: The pooled crude odds ratios in statin users as compared with nonusers were 0.67 (95% confidence interval CI 0.54-0.82) in the dementia group and 0.81 (95% CI 0.64-1.02) in the Alzheimer group. The pooled adjusted relative risks calculated by random-effects model were 0.77 (95% CI 0.45-1.30) in the dementia group and 0.81 (95% CI 0.56-1.16) in the Alzheimer group. CONCLUSIONS: Statin use did not show a beneficial effect on the risk of dementia or Alzheimer's disease. Further study and independent confirmation of the association between statin use and dementia and Alzheimer's disease in larger clinical trials are warranted. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/17259710/Prevention_and_treatment_of_dementia_or_Alzheimer's_disease_by_statins:_a_meta_analysis_ L2 - https://www.karger.com?DOI=10.1159/000099037 DB - PRIME DP - Unbound Medicine ER -