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Full-length sequences of two hepatitis E virus isolates representing an Eastern China-indigenous subgroup of genotype 4.
Intervirology. 2007; 50(3):181-9.I

Abstract

Although the majority of hepatitis E virus (HEV) infections in Japan are 'domestic' due to the presence of indigenous strains, there are still 'imported' cases as well. Among 83 patients with non-A, non-B and non-C acute liver diseases admitted to Saitama Medical University Hospital, 7 (8.4%) were positive for serum HEV-RNA, of whom 2 had a recent history of traveling to China, one to Xian and another to Shanghai. We determined the full-genome sequences of HEV from these 2 patients (isolate names are JKO-ChiSai98c and JYI-ChiSai01c, genotype 4 in both) for phylogenetic analyses. Initially, when compared only to the 13 full-genome sequences of genotype 4 so far reported, our 2 isolates were thought to be novel strains because they showed a significant genetic difference from the sequences known to date. However, when we included a set of short sequences (150 nt) recently reported from China in the comparison, we found that our 2 isolates represent a subgroup of genotype 4, which seems to be restricted to eastern China. In conclusion, the 2 HEV isolates reported here could serve as full-genome prototypes for an eastern China-indigenous subgroup of the genotype 4 HEV.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saitama Medical University, Saitama, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17259737

Citation

Koike, Masami, et al. "Full-length Sequences of Two Hepatitis E Virus Isolates Representing an Eastern China-indigenous Subgroup of Genotype 4." Intervirology, vol. 50, no. 3, 2007, pp. 181-9.
Koike M, Takahashi K, Mishiro S, et al. Full-length sequences of two hepatitis E virus isolates representing an Eastern China-indigenous subgroup of genotype 4. Intervirology. 2007;50(3):181-9.
Koike, M., Takahashi, K., Mishiro, S., Matsui, A., Inao, M., Nagoshi, S., Ohno, A., Mochida, S., & Fujiwara, K. (2007). Full-length sequences of two hepatitis E virus isolates representing an Eastern China-indigenous subgroup of genotype 4. Intervirology, 50(3), 181-9.
Koike M, et al. Full-length Sequences of Two Hepatitis E Virus Isolates Representing an Eastern China-indigenous Subgroup of Genotype 4. Intervirology. 2007;50(3):181-9. PubMed PMID: 17259737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Full-length sequences of two hepatitis E virus isolates representing an Eastern China-indigenous subgroup of genotype 4. AU - Koike,Masami, AU - Takahashi,Kazuaki, AU - Mishiro,Shunji, AU - Matsui,Atsushi, AU - Inao,Mie, AU - Nagoshi,Sumiko, AU - Ohno,Akihiko, AU - Mochida,Satoshi, AU - Fujiwara,Kenji, Y1 - 2007/01/26/ PY - 2006/08/05/received PY - 2006/09/27/accepted PY - 2007/1/30/pubmed PY - 2007/10/17/medline PY - 2007/1/30/entrez SP - 181 EP - 9 JF - Intervirology JO - Intervirology VL - 50 IS - 3 N2 - Although the majority of hepatitis E virus (HEV) infections in Japan are 'domestic' due to the presence of indigenous strains, there are still 'imported' cases as well. Among 83 patients with non-A, non-B and non-C acute liver diseases admitted to Saitama Medical University Hospital, 7 (8.4%) were positive for serum HEV-RNA, of whom 2 had a recent history of traveling to China, one to Xian and another to Shanghai. We determined the full-genome sequences of HEV from these 2 patients (isolate names are JKO-ChiSai98c and JYI-ChiSai01c, genotype 4 in both) for phylogenetic analyses. Initially, when compared only to the 13 full-genome sequences of genotype 4 so far reported, our 2 isolates were thought to be novel strains because they showed a significant genetic difference from the sequences known to date. However, when we included a set of short sequences (150 nt) recently reported from China in the comparison, we found that our 2 isolates represent a subgroup of genotype 4, which seems to be restricted to eastern China. In conclusion, the 2 HEV isolates reported here could serve as full-genome prototypes for an eastern China-indigenous subgroup of the genotype 4 HEV. SN - 0300-5526 UR - https://www.unboundmedicine.com/medline/citation/17259737/Full_length_sequences_of_two_hepatitis_E_virus_isolates_representing_an_Eastern_China_indigenous_subgroup_of_genotype_4_ L2 - https://www.karger.com?DOI=10.1159/000098961 DB - PRIME DP - Unbound Medicine ER -