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Immunogenicity of an inactivated hepatitis A vaccine in infants and young children.
Pediatr Infect Dis J. 2007 Feb; 26(2):116-22.PI

Abstract

BACKGROUND

Infants with passively transferred maternal antibody, born to mothers immune to hepatitis A virus (HAV), have a blunted response to hepatitis A (HA) vaccine. We compared HA vaccine immunogenicity among infants born to immune and susceptible mothers, vaccinated on different schedules.

METHODS

Infants were randomized into 3 groups, each receiving 2 doses of 720 EL.U. of HA vaccine (HAVRIX; Glaxo SmithKline): group 1 at ages 6 and 12 months, group 2 at ages 12 and 18 months and group 3 at ages 15 and 21 months. We determined mothers' antibody to HAV (anti-HAV) status and infants' anti-HAV concentrations at the first vaccine dose (baseline) and at 1, 7 and 12 months thereafter. All were tested at age 13 months for responses to recommended routine vaccinations administered during infancy.

RESULTS

Of 248 participants, 140 were born to HA-susceptible mothers and 108 to immune mothers. At baseline, 34 of 36 (94%) group 1, 5 of 34 (15%) group 2 and one of 38 (3%) group 3 infants born to immune mothers were seropositive. By month 7, all participants in all groups were seropositive except group 1 infants born to immune mothers (34 of 36 [94%], seropositive). In group 1, peak geometric mean concentrations between infants born to immune (794 mIU/mL) and susceptible (2083 mIU/mL) mothers were significantly different. Across groups, peak geometric mean concentrations were similar among infants born to susceptible mothers (3166 mIU/mL, group 2; 3153 mIU/mL, group 3). Among infants born to immune mothers, the difference between groups 1 and 3 (2715 mIU/mL) was significant. There were no differences in responses to routine vaccinations.

CONCLUSIONS

HA vaccine is immunogenic among infants born to HA-susceptible mothers and those born to immune mothers and vaccinated beginning > or =12 months old. Passively transferred maternal antibody persists for at least 6 months and results in a blunted response to HA vaccination.

Authors+Show Affiliations

Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA. bzb8@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17259872

Citation

Bell, Beth P., et al. "Immunogenicity of an Inactivated Hepatitis a Vaccine in Infants and Young Children." The Pediatric Infectious Disease Journal, vol. 26, no. 2, 2007, pp. 116-22.
Bell BP, Negus S, Fiore AE, et al. Immunogenicity of an inactivated hepatitis A vaccine in infants and young children. Pediatr Infect Dis J. 2007;26(2):116-22.
Bell, B. P., Negus, S., Fiore, A. E., Plotnik, J., Dhotre, K. B., Williams, J., Shapiro, C. N., & McMahon, B. J. (2007). Immunogenicity of an inactivated hepatitis A vaccine in infants and young children. The Pediatric Infectious Disease Journal, 26(2), 116-22.
Bell BP, et al. Immunogenicity of an Inactivated Hepatitis a Vaccine in Infants and Young Children. Pediatr Infect Dis J. 2007;26(2):116-22. PubMed PMID: 17259872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunogenicity of an inactivated hepatitis A vaccine in infants and young children. AU - Bell,Beth P, AU - Negus,Susan, AU - Fiore,Anthony E, AU - Plotnik,Julia, AU - Dhotre,Kathy Boaz, AU - Williams,James, AU - Shapiro,Craig N, AU - McMahon,Brian J, PY - 2007/1/30/pubmed PY - 2007/3/16/medline PY - 2007/1/30/entrez SP - 116 EP - 22 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 26 IS - 2 N2 - BACKGROUND: Infants with passively transferred maternal antibody, born to mothers immune to hepatitis A virus (HAV), have a blunted response to hepatitis A (HA) vaccine. We compared HA vaccine immunogenicity among infants born to immune and susceptible mothers, vaccinated on different schedules. METHODS: Infants were randomized into 3 groups, each receiving 2 doses of 720 EL.U. of HA vaccine (HAVRIX; Glaxo SmithKline): group 1 at ages 6 and 12 months, group 2 at ages 12 and 18 months and group 3 at ages 15 and 21 months. We determined mothers' antibody to HAV (anti-HAV) status and infants' anti-HAV concentrations at the first vaccine dose (baseline) and at 1, 7 and 12 months thereafter. All were tested at age 13 months for responses to recommended routine vaccinations administered during infancy. RESULTS: Of 248 participants, 140 were born to HA-susceptible mothers and 108 to immune mothers. At baseline, 34 of 36 (94%) group 1, 5 of 34 (15%) group 2 and one of 38 (3%) group 3 infants born to immune mothers were seropositive. By month 7, all participants in all groups were seropositive except group 1 infants born to immune mothers (34 of 36 [94%], seropositive). In group 1, peak geometric mean concentrations between infants born to immune (794 mIU/mL) and susceptible (2083 mIU/mL) mothers were significantly different. Across groups, peak geometric mean concentrations were similar among infants born to susceptible mothers (3166 mIU/mL, group 2; 3153 mIU/mL, group 3). Among infants born to immune mothers, the difference between groups 1 and 3 (2715 mIU/mL) was significant. There were no differences in responses to routine vaccinations. CONCLUSIONS: HA vaccine is immunogenic among infants born to HA-susceptible mothers and those born to immune mothers and vaccinated beginning > or =12 months old. Passively transferred maternal antibody persists for at least 6 months and results in a blunted response to HA vaccination. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/17259872/Immunogenicity_of_an_inactivated_hepatitis_A_vaccine_in_infants_and_young_children_ L2 - https://doi.org/10.1097/01.inf.0000253253.85640.cc DB - PRIME DP - Unbound Medicine ER -