Tags

Type your tag names separated by a space and hit enter

Benzodiazepines and GABAergics in treating severe disabling tinnitus of predominantly cochlear origin.
Int Tinnitus J. 2006; 12(2):140-4.IT

Abstract

Severe disabling tinnitus (SDT) refers to a symptom severe enough to disrupt affected patients' routine and keep them from performing their daily activities. SDT of a predominantly central origin has been treated successfully with benzodiazepines and GABAergic drugs. Our aim was to test the control of SDT of predominantly cochlear origin by benzodiazepines and GABAergic drugs. We followed the format of a prospective, randomized, single-blind clinical trial at an academic tertiary-care hospital. We studied 30 patients, all with SDT of clear cochlear origin. We treated 10 patients with placebo (group 1), 10 with benzodiazepine drugs (group 2), and 10 with benzodiazepine and GABAergic drugs (group 3). We recorded a decrease in the annoyance and intensity of SDT as measured by a visual analog scale ranging from 1 (negligible) to 10 (unbearable). We found statistically significant improvement in comparing groups 2 and 3 with group 1 but found no significant difference when groups 2 and 3 were compared. Addition of GABAergic to benzodiazepine drugs does not modify the treatment results in SDT of a predominantly cochlear origin.

Authors+Show Affiliations

Department of Otolaryngology, Brasilia University Medical School, Brasilia-DF, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17260879

Citation

Bahmad, Fayez M., et al. "Benzodiazepines and GABAergics in Treating Severe Disabling Tinnitus of Predominantly Cochlear Origin." The International Tinnitus Journal, vol. 12, no. 2, 2006, pp. 140-4.
Bahmad FM, Venosa AR, Oliveira CA. Benzodiazepines and GABAergics in treating severe disabling tinnitus of predominantly cochlear origin. Int Tinnitus J. 2006;12(2):140-4.
Bahmad, F. M., Venosa, A. R., & Oliveira, C. A. (2006). Benzodiazepines and GABAergics in treating severe disabling tinnitus of predominantly cochlear origin. The International Tinnitus Journal, 12(2), 140-4.
Bahmad FM, Venosa AR, Oliveira CA. Benzodiazepines and GABAergics in Treating Severe Disabling Tinnitus of Predominantly Cochlear Origin. Int Tinnitus J. 2006;12(2):140-4. PubMed PMID: 17260879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benzodiazepines and GABAergics in treating severe disabling tinnitus of predominantly cochlear origin. AU - Bahmad,Fayez M,Jr AU - Venosa,Alessandra R, AU - Oliveira,Carlos A, PY - 2007/1/31/pubmed PY - 2007/6/21/medline PY - 2007/1/31/entrez SP - 140 EP - 4 JF - The international tinnitus journal JO - Int Tinnitus J VL - 12 IS - 2 N2 - Severe disabling tinnitus (SDT) refers to a symptom severe enough to disrupt affected patients' routine and keep them from performing their daily activities. SDT of a predominantly central origin has been treated successfully with benzodiazepines and GABAergic drugs. Our aim was to test the control of SDT of predominantly cochlear origin by benzodiazepines and GABAergic drugs. We followed the format of a prospective, randomized, single-blind clinical trial at an academic tertiary-care hospital. We studied 30 patients, all with SDT of clear cochlear origin. We treated 10 patients with placebo (group 1), 10 with benzodiazepine drugs (group 2), and 10 with benzodiazepine and GABAergic drugs (group 3). We recorded a decrease in the annoyance and intensity of SDT as measured by a visual analog scale ranging from 1 (negligible) to 10 (unbearable). We found statistically significant improvement in comparing groups 2 and 3 with group 1 but found no significant difference when groups 2 and 3 were compared. Addition of GABAergic to benzodiazepine drugs does not modify the treatment results in SDT of a predominantly cochlear origin. SN - 0946-5448 UR - https://www.unboundmedicine.com/medline/citation/17260879/Benzodiazepines_and_GABAergics_in_treating_severe_disabling_tinnitus_of_predominantly_cochlear_origin_ L2 - http://www.diseaseinfosearch.org/result/9653 DB - PRIME DP - Unbound Medicine ER -