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Scheduled prophylactic ondansetron administration did not improve its antiemetic efficacy after intracranial tumour resection surgery in children.
Eur J Anaesthesiol. 2007 Jul; 24(7):615-9.EJ

Abstract

BACKGROUND AND OBJECTIVE

Postoperative nausea and vomiting after craniotomy may increase intracranial pressure and morbidity in children. This prospective, randomized, placebo-controlled and double-blinded study was designed to evaluate the antiemetic efficacy of prophylactic ondansetron after intracranial tumour resections in children.

METHODS

Ninety children were divided into three groups and received saline (Group 1), ondansetron 150 microg kg-1 intravenously at dural closure (Group 2) or two doses of ondansetron 150 microg kg-1 intravenously, the second dose repeated after 6 h (Group 3). Episodes of nausea, emesis and side-effects were noted for 24 h postoperatively.

RESULTS

Overall 24 h incidence of postoperative nausea and vomiting was not significantly different among the three groups (9 (37.5%) in Group 1 vs. 7 (27%) in Group 2 and 8 (32%) in Group 3, P = 0.73). No difference in rescue antiemetic treatment or postoperative nausea and vomiting at specific time intervals (0-6 and 6-24 h postoperative period) was seen among the three groups. No significant side-effects were noted in any of the three groups.

CONCLUSIONS

Ondansetron, in this study of 90 children, was not very effective in preventing nausea and vomiting after neurosurgical operations.

Authors+Show Affiliations

University of Pittsburgh Medical Center, Department of Anaesthesiology, Pittsburgh, PA, USA. subramaniamk@upmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17261211

Citation

Subramaniam, K, et al. "Scheduled Prophylactic Ondansetron Administration Did Not Improve Its Antiemetic Efficacy After Intracranial Tumour Resection Surgery in Children." European Journal of Anaesthesiology, vol. 24, no. 7, 2007, pp. 615-9.
Subramaniam K, Pandia MP, Dash M, et al. Scheduled prophylactic ondansetron administration did not improve its antiemetic efficacy after intracranial tumour resection surgery in children. Eur J Anaesthesiol. 2007;24(7):615-9.
Subramaniam, K., Pandia, M. P., Dash, M., Dash, H. H., Bithal, P. K., Bhatia, A., & Subramaniam, B. (2007). Scheduled prophylactic ondansetron administration did not improve its antiemetic efficacy after intracranial tumour resection surgery in children. European Journal of Anaesthesiology, 24(7), 615-9.
Subramaniam K, et al. Scheduled Prophylactic Ondansetron Administration Did Not Improve Its Antiemetic Efficacy After Intracranial Tumour Resection Surgery in Children. Eur J Anaesthesiol. 2007;24(7):615-9. PubMed PMID: 17261211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scheduled prophylactic ondansetron administration did not improve its antiemetic efficacy after intracranial tumour resection surgery in children. AU - Subramaniam,K, AU - Pandia,M P, AU - Dash,M, AU - Dash,H H, AU - Bithal,P K, AU - Bhatia,A, AU - Subramaniam,B, Y1 - 2007/01/30/ PY - 2007/1/31/pubmed PY - 2007/8/1/medline PY - 2007/1/31/entrez SP - 615 EP - 9 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 24 IS - 7 N2 - BACKGROUND AND OBJECTIVE: Postoperative nausea and vomiting after craniotomy may increase intracranial pressure and morbidity in children. This prospective, randomized, placebo-controlled and double-blinded study was designed to evaluate the antiemetic efficacy of prophylactic ondansetron after intracranial tumour resections in children. METHODS: Ninety children were divided into three groups and received saline (Group 1), ondansetron 150 microg kg-1 intravenously at dural closure (Group 2) or two doses of ondansetron 150 microg kg-1 intravenously, the second dose repeated after 6 h (Group 3). Episodes of nausea, emesis and side-effects were noted for 24 h postoperatively. RESULTS: Overall 24 h incidence of postoperative nausea and vomiting was not significantly different among the three groups (9 (37.5%) in Group 1 vs. 7 (27%) in Group 2 and 8 (32%) in Group 3, P = 0.73). No difference in rescue antiemetic treatment or postoperative nausea and vomiting at specific time intervals (0-6 and 6-24 h postoperative period) was seen among the three groups. No significant side-effects were noted in any of the three groups. CONCLUSIONS: Ondansetron, in this study of 90 children, was not very effective in preventing nausea and vomiting after neurosurgical operations. SN - 0265-0215 UR - https://www.unboundmedicine.com/medline/citation/17261211/Scheduled_prophylactic_ondansetron_administration_did_not_improve_its_antiemetic_efficacy_after_intracranial_tumour_resection_surgery_in_children_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=17261211.ui DB - PRIME DP - Unbound Medicine ER -