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Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement.
Breast Cancer Res Treat 2007; 106(3):433-8BC

Abstract

Endothelial nitric oxide synthase (NOS3) produces nitric oxide which is a mediator of cytotoxic effects potentially associated with breast cancer. We evaluated the role of genetic polymorphisms of NOS3 in breast cancer etiology, in a case-control study conducted in Korea. We recruited 1,385 eligible patients with histologically confirmed incident breast cancer cases and 968 hospital-based controls. Two potentially functional NOS3 polymorphisms in the promoter region (-786T > C) and exon 7 (894G > T, Glu298Asp) were genotyped and individual haplotypes were estimated. Odds ratios (ORs) and 95% confidential intervals (95% CIs) were calculated by unconditional logistic regression, adjusting for age, body mass index, education, family history of breast cancer in first and second degree relatives, age at first full-term pregnancy and parity. There was no overall association between the -786T > C or 894G > T genotype and breast cancer risk. However, the -786C allele was marginally associated with decreased risk for invasive breast cancer with lymph node involvement (OR = 0.76, 95% CI = 0.56-1.04). And, compared to TG-TG carriers, all other haplotype pairs were significantly associated with invasive breast cancer with lymph node involvement (OR = 0.77, 95% CI = 0.59-0.99). Our results suggest that genetic polymorphisms in NOS3 modify individual susceptibility to invasive breast cancer with lymph node involvement in Korean women.

Authors+Show Affiliations

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17262178

Citation

Lee, Kyoung-Mu, et al. "Genetic Polymorphisms of NOS3 Are Associated With the Risk of Invasive Breast Cancer With Lymph Node Involvement." Breast Cancer Research and Treatment, vol. 106, no. 3, 2007, pp. 433-8.
Lee KM, Choi JY, Lee JE, et al. Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement. Breast Cancer Res Treat. 2007;106(3):433-8.
Lee, K. M., Choi, J. Y., Lee, J. E., Noh, D. Y., Ahn, S. H., Han, W., ... Kang, D. (2007). Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement. Breast Cancer Research and Treatment, 106(3), pp. 433-8.
Lee KM, et al. Genetic Polymorphisms of NOS3 Are Associated With the Risk of Invasive Breast Cancer With Lymph Node Involvement. Breast Cancer Res Treat. 2007;106(3):433-8. PubMed PMID: 17262178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement. AU - Lee,Kyoung-Mu, AU - Choi,Ji-Yeob, AU - Lee,Jong Eun, AU - Noh,Dong-Young, AU - Ahn,Sei-Hyun, AU - Han,Wonshik, AU - Yoo,Keun-Young, AU - Hayes,Richard B, AU - Kang,Daehee, Y1 - 2007/01/30/ PY - 2006/12/19/received PY - 2007/01/01/accepted PY - 2007/1/31/pubmed PY - 2008/1/25/medline PY - 2007/1/31/entrez SP - 433 EP - 8 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 106 IS - 3 N2 - Endothelial nitric oxide synthase (NOS3) produces nitric oxide which is a mediator of cytotoxic effects potentially associated with breast cancer. We evaluated the role of genetic polymorphisms of NOS3 in breast cancer etiology, in a case-control study conducted in Korea. We recruited 1,385 eligible patients with histologically confirmed incident breast cancer cases and 968 hospital-based controls. Two potentially functional NOS3 polymorphisms in the promoter region (-786T > C) and exon 7 (894G > T, Glu298Asp) were genotyped and individual haplotypes were estimated. Odds ratios (ORs) and 95% confidential intervals (95% CIs) were calculated by unconditional logistic regression, adjusting for age, body mass index, education, family history of breast cancer in first and second degree relatives, age at first full-term pregnancy and parity. There was no overall association between the -786T > C or 894G > T genotype and breast cancer risk. However, the -786C allele was marginally associated with decreased risk for invasive breast cancer with lymph node involvement (OR = 0.76, 95% CI = 0.56-1.04). And, compared to TG-TG carriers, all other haplotype pairs were significantly associated with invasive breast cancer with lymph node involvement (OR = 0.77, 95% CI = 0.59-0.99). Our results suggest that genetic polymorphisms in NOS3 modify individual susceptibility to invasive breast cancer with lymph node involvement in Korean women. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/17262178/Genetic_polymorphisms_of_NOS3_are_associated_with_the_risk_of_invasive_breast_cancer_with_lymph_node_involvement_ L2 - https://doi.org/10.1007/s10549-007-9506-y DB - PRIME DP - Unbound Medicine ER -